Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888890189> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2888890189 endingPage "473" @default.
- W2888890189 startingPage "473" @default.
- W2888890189 abstract "Objective: To explore the antihypertensive effect of extracts from the leaves of Hedera helix (H. helix) on normotensive and hypertensive rats in-vivo followed by vasodilatory studies in-vitro. Methods: The crude methanolic extract was prepared and the activity directed fractionation was carried out. Spectrophotometric analysis of total phenolic and flavonoid content was also done. HPLC analysis was performed for the detection of hederacoside C. In-vivo blood pressure study was carried out in normotensive and high salt-induced hypertensive Sprague-Dawley rats. Isolated aortic tissues from rat and rabbit were used for in-vitro studies. The effects were recorded and analyzed through PowerLab data acquisition system. Results: Crude extract of H. helix (1-30 mg/kg) decreased blood pressure to greater extent in high salt-induced hypertensive rats in-vivo compared to the normotensive [Max. fall (58.59±0.02) mmHg vs. (67.53±3.07) mmHg]. The n-hexane, chloroform, ethyl acetate and aqueous fractions were also checked. These fractions were more effective in hypertensive rats. Aqueous fraction was more potent and n-hexane the least. In isolated rat aortic rings precontracted with phenylephrine, crude extract induced endothelium-dependent effect. The endothelium-dependent component of vasodilatory effect was ablated with L-NAME, and denudation of endothelium. The aqueous fraction was most potent vasodilator. In aortic rings from hypertensive rats, extract and fractions produced partial endothelium-independent effect which was not affected by pretreatment with L-NAME, indicating endothelium dysfunction in the hypertensive rats and suggesting additional vasodilatory mechanisms. In rabbit aorta, the extract and fractions also inhibited phenylephrine and high K+ -induced precontractions, and shifted Ca++ concentration-response curves. Conclusions: Our findings indicate that extract and fractions of H. helix are antihypertensive remedies, which is the outcome of vasodilatory effect. This vasodilatory effect is mediated through nitric oxide and Ca++ antagonism." @default.
- W2888890189 created "2018-09-07" @default.
- W2888890189 creator A5011426398 @default.
- W2888890189 creator A5040261389 @default.
- W2888890189 creator A5060666105 @default.
- W2888890189 date "2018-01-01" @default.
- W2888890189 modified "2023-09-23" @default.
- W2888890189 title "Antihypertensive efficacy of extract of Hedera helix in high salt-induced hypertensive Sprague-Dawley rats" @default.
- W2888890189 cites W2017902822 @default.
- W2888890189 cites W2075629486 @default.
- W2888890189 cites W4249898105 @default.
- W2888890189 doi "https://doi.org/10.4103/1995-7645.240083" @default.
- W2888890189 hasPublicationYear "2018" @default.
- W2888890189 type Work @default.
- W2888890189 sameAs 2888890189 @default.
- W2888890189 citedByCount "3" @default.
- W2888890189 countsByYear W28888901892019 @default.
- W2888890189 countsByYear W28888901892022 @default.
- W2888890189 crossrefType "journal-article" @default.
- W2888890189 hasAuthorship W2888890189A5011426398 @default.
- W2888890189 hasAuthorship W2888890189A5040261389 @default.
- W2888890189 hasAuthorship W2888890189A5060666105 @default.
- W2888890189 hasBestOaLocation W28888901891 @default.
- W2888890189 hasConcept C120770815 @default.
- W2888890189 hasConcept C134018914 @default.
- W2888890189 hasConcept C150903083 @default.
- W2888890189 hasConcept C185592680 @default.
- W2888890189 hasConcept C207001950 @default.
- W2888890189 hasConcept C2776992346 @default.
- W2888890189 hasConcept C2777952589 @default.
- W2888890189 hasConcept C2778086073 @default.
- W2888890189 hasConcept C2781438886 @default.
- W2888890189 hasConcept C59822182 @default.
- W2888890189 hasConcept C71924100 @default.
- W2888890189 hasConcept C84393581 @default.
- W2888890189 hasConcept C86803240 @default.
- W2888890189 hasConcept C98274493 @default.
- W2888890189 hasConceptScore W2888890189C120770815 @default.
- W2888890189 hasConceptScore W2888890189C134018914 @default.
- W2888890189 hasConceptScore W2888890189C150903083 @default.
- W2888890189 hasConceptScore W2888890189C185592680 @default.
- W2888890189 hasConceptScore W2888890189C207001950 @default.
- W2888890189 hasConceptScore W2888890189C2776992346 @default.
- W2888890189 hasConceptScore W2888890189C2777952589 @default.
- W2888890189 hasConceptScore W2888890189C2778086073 @default.
- W2888890189 hasConceptScore W2888890189C2781438886 @default.
- W2888890189 hasConceptScore W2888890189C59822182 @default.
- W2888890189 hasConceptScore W2888890189C71924100 @default.
- W2888890189 hasConceptScore W2888890189C84393581 @default.
- W2888890189 hasConceptScore W2888890189C86803240 @default.
- W2888890189 hasConceptScore W2888890189C98274493 @default.
- W2888890189 hasIssue "8" @default.
- W2888890189 hasLocation W28888901891 @default.
- W2888890189 hasLocation W28888901892 @default.
- W2888890189 hasOpenAccess W2888890189 @default.
- W2888890189 hasPrimaryLocation W28888901891 @default.
- W2888890189 hasRelatedWork W1990561758 @default.
- W2888890189 hasRelatedWork W2040962574 @default.
- W2888890189 hasRelatedWork W2085194324 @default.
- W2888890189 hasRelatedWork W2358133512 @default.
- W2888890189 hasRelatedWork W2367498568 @default.
- W2888890189 hasRelatedWork W2379293345 @default.
- W2888890189 hasRelatedWork W2400017346 @default.
- W2888890189 hasRelatedWork W2415135799 @default.
- W2888890189 hasRelatedWork W2469574821 @default.
- W2888890189 hasRelatedWork W4281712321 @default.
- W2888890189 hasVolume "11" @default.
- W2888890189 isParatext "false" @default.
- W2888890189 isRetracted "false" @default.
- W2888890189 magId "2888890189" @default.
- W2888890189 workType "article" @default.