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- W2888894833 abstract "Neutrophils are short-lived cells that play important roles in both health and disease. Neutrophils and monocytes originate from the granulocyte monocyte progenitor (GMP) in bone marrow; however, unipotent neutrophil progenitors are not well defined. Here, we use cytometry by time of flight (CyTOF) and single-cell RNA sequencing (scRNA-seq) methodologies to identify a committed unipotent early-stage neutrophil progenitor (NeP) in adult mouse bone marrow. Importantly, we found a similar unipotent NeP (hNeP) in human bone marrow. Both NeP and hNeP generate only neutrophils. NeP and hNeP both significantly increase tumor growth when transferred into murine cancer models, including a humanized mouse model. hNeP are present in the blood of treatment-naive melanoma patients but not of healthy subjects. hNeP can be readily identified by flow cytometry and could be used as a biomarker for early cancer discovery. Understanding the biology of hNeP should allow the development of new therapeutic targets for neutrophil-related diseases, including cancer." @default.
- W2888894833 created "2018-09-07" @default.
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- W2888894833 date "2018-08-01" @default.
- W2888894833 modified "2023-10-14" @default.
- W2888894833 title "Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow" @default.
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- W2888894833 doi "https://doi.org/10.1016/j.celrep.2018.07.097" @default.
- W2888894833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6542273" @default.
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- W2888894833 hasPublicationYear "2018" @default.
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