FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888895951> ?p ?o ?g. }

• W2888895951 abstract "Psoriasis is an autoimmune and inflammatory skin disease affecting around 2-3% of the world’s population. Patients with psoriasis need extensive treatments with global immunosuppressive agents that may cause severe side effects. Esculetin, a type of coumarins, is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla, which has been used to treat inflammatory and autoimmune diseases in China. However, the antipsoriatic effects of esculetin have not been reported. In this study, we aimed to investigate the effects of esculetin on psoriatic skin inflammation in a mouse model and explored the potential molecular mechanisms underlying its action. We found that esculetin ameliorated the skin lesion and reduced PASI scores as well as weight loss in imiquimod-induced psoriasis-like mice, accompanied with weakened proliferation and differentiation of keratinocytes and CD3+ T cell infiltration in esculetin-treated psoriatic mice. In addition, esculetin reduced the frequency of CD8+CD44highCD62Llow effector T cells in psoriatic mice. In contrast, it increased the frequency of CD4+Foxp3+ Tregs in both lymph nodes and spleens of the psoriatic mice while promoting the differentiation of CD4+CD25- T cells into CD4+Foxp3+ Tregs in vitro. Interestingly, depleting CD4+Foxp3+ Tregs largely reversed esculetin-mediated reduction in PASI scores, indicating that esculetin attenuates murine psoriasis mainly by inducing CD4+Foxp3+ Tregs. Furthermore, the mRNA levels of proinflammatory cytokines in the psoriatic mouse skin, including IL-6, IL-17A, IL-22, IL-23, TNF-α and IFN-γ, were dramatically decreased by the treatment with esculetin. Finally, we found that esculetin inhibited the phosphorylation of IKKα and P65 in the psoriatic skin, suggesting that it inhibits the activation of NF-κB signaling. Thus, we have demonstrated that esculetin attenuates the psoriasis-like skin lesion in mice and may be a potential therapeutic candidate for the treatment of psoriasis in clinic." @default.
• W2888895951 created "2018-09-07" @default.
• W2888895951 creator A5010924929 @default.
• W2888895951 creator A5019118491 @default.
• W2888895951 creator A5024123604 @default.
• W2888895951 creator A5031618260 @default.
• W2888895951 creator A5045118946 @default.
• W2888895951 creator A5049403942 @default.
• W2888895951 creator A5053502733 @default.
• W2888895951 creator A5070880850 @default.
• W2888895951 date "2018-09-12" @default.
• W2888895951 modified "2023-10-18" @default.
• W2888895951 title "Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells" @default.
• W2888895951 cites W1486451271 @default.
• W2888895951 cites W1918751531 @default.
• W2888895951 cites W1939997832 @default.
• W2888895951 cites W1965994758 @default.
• W2888895951 cites W1969797237 @default.
• W2888895951 cites W1971708477 @default.
• W2888895951 cites W1974208182 @default.
• W2888895951 cites W1986646780 @default.
• W2888895951 cites W1986981350 @default.
• W2888895951 cites W1993776532 @default.
• W2888895951 cites W1997977761 @default.
• W2888895951 cites W2002756960 @default.
• W2888895951 cites W2017515632 @default.
• W2888895951 cites W2018353201 @default.
• W2888895951 cites W2019291297 @default.
• W2888895951 cites W2025035158 @default.
• W2888895951 cites W2040790884 @default.
• W2888895951 cites W2043754109 @default.
• W2888895951 cites W2054083392 @default.
• W2888895951 cites W2056361036 @default.
• W2888895951 cites W2058863496 @default.
• W2888895951 cites W2061600342 @default.
• W2888895951 cites W2062129011 @default.
• W2888895951 cites W2066142965 @default.
• W2888895951 cites W2067204485 @default.
• W2888895951 cites W2080090843 @default.
• W2888895951 cites W2080460220 @default.
• W2888895951 cites W2084560238 @default.
• W2888895951 cites W2085041842 @default.
• W2888895951 cites W2104684016 @default.
• W2888895951 cites W2114524747 @default.
• W2888895951 cites W2121007697 @default.
• W2888895951 cites W2121126920 @default.
• W2888895951 cites W2135299099 @default.
• W2888895951 cites W2142729262 @default.
• W2888895951 cites W2160683795 @default.
• W2888895951 cites W2162482755 @default.
• W2888895951 cites W2170659823 @default.
• W2888895951 cites W2185664954 @default.
• W2888895951 cites W2214829447 @default.
• W2888895951 cites W2220598743 @default.
• W2888895951 cites W2227866787 @default.
• W2888895951 cites W2254667085 @default.
• W2888895951 cites W2262684285 @default.
• W2888895951 cites W2269569969 @default.
• W2888895951 cites W2282196985 @default.
• W2888895951 cites W2343827751 @default.
• W2888895951 cites W2501269813 @default.
• W2888895951 cites W2516243166 @default.
• W2888895951 cites W2526796770 @default.
• W2888895951 cites W2545448851 @default.
• W2888895951 cites W2562991632 @default.
• W2888895951 cites W2581694607 @default.
• W2888895951 cites W2583571194 @default.
• W2888895951 cites W2588465285 @default.
• W2888895951 cites W2593109836 @default.
• W2888895951 cites W2599224390 @default.
• W2888895951 cites W2612866442 @default.
• W2888895951 cites W2621594992 @default.
• W2888895951 cites W2626962960 @default.
• W2888895951 cites W2745712403 @default.
• W2888895951 cites W2752699963 @default.
• W2888895951 cites W2766761708 @default.
• W2888895951 cites W2766886761 @default.
• W2888895951 cites W2767978529 @default.
• W2888895951 cites W2768263390 @default.
• W2888895951 cites W2776033345 @default.
• W2888895951 cites W2782065905 @default.
• W2888895951 cites W2785547592 @default.
• W2888895951 cites W2790240293 @default.
• W2888895951 cites W2791900941 @default.
• W2888895951 cites W2792904772 @default.
• W2888895951 cites W2797551684 @default.
• W2888895951 cites W2797624079 @default.
• W2888895951 cites W2801310089 @default.
• W2888895951 cites W2820841600 @default.
• W2888895951 cites W4237627879 @default.
• W2888895951 cites W48542225 @default.
• W2888895951 cites W67503192 @default.
• W2888895951 doi "https://doi.org/10.3389/fimmu.2018.02092" @default.
• W2888895951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143660" @default.
• W2888895951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30258447" @default.
• W2888895951 hasPublicationYear "2018" @default.
• W2888895951 type Work @default.
• W2888895951 sameAs 2888895951 @default.
• W2888895951 citedByCount "31" @default.
• W2888895951 countsByYear W28888959512019 @default.

• next