FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888896319> ?p ?o ?g. }

• W2888896319 endingPage "1513" @default.
• W2888896319 startingPage "1504" @default.
• W2888896319 abstract "Abstract Aim The aim of this study was to explore the mechanism underlying the protective effects of 2,3,5,4‐tetrahydroxystilbene‐2‐o‐β‐D‐glucoside (TSG) against osteoporosis. Method MC3T3‐E1 mouse osteoblast precursor cells were used to analyze the protective effects of TSG on osteoblast apoptosis and differential inhibition induced by oxidative stress to determine the gene expression of forkhead transcription factor FKHRL1 (FoxO3a), T cell factors (TCFs), and downstream genes. A mouse model was used to assess the protective effects of TSG on ovariectomy‐induced osteoporosis as well as on Cell Counting Kit‐8 (CCK) gene expression, including that of FoxO3a. The mechanism underlying the protective effects of TSG against osteoporosis was further explored using high‐throughput sequencing data. Results A CCK‐8 assay in MC3T3‐E1 cells and hematoxylin and eosin staining in mouse tissue indicated that cell viability and bone tissue development were inhibited by oxidative stress and ovariectomy and that TSG neutralized or attenuated this effect. The expression levels of FoxO3a, TCF, and downstream genes and the indices of oxidative stress were the same in MC3T3‐E1 cells and the bone tissues of the mouse model. Bioinformatics analysis indicated that the cardiac muscle contraction and chemokine signaling pathway were disturbed in MC3T3‐E1 cells treated with hydrogen peroxide. Gene ontology‐biological process analysis revealed the influence of TSG treatment. Conclusion Osteoporosis and cardiac diseases appear to share a common mechanism. In addition to Wnt/FoxO3a signaling, the immune system and the chemokine signaling pathway may contribute to the protective mechanism of TSG." @default.
• W2888896319 created "2018-09-07" @default.
• W2888896319 creator A5004331982 @default.
• W2888896319 creator A5027232307 @default.
• W2888896319 creator A5034977430 @default.
• W2888896319 creator A5035774966 @default.
• W2888896319 creator A5050304168 @default.
• W2888896319 creator A5063499064 @default.
• W2888896319 creator A5076306578 @default.
• W2888896319 creator A5084191075 @default.
• W2888896319 creator A5090318045 @default.
• W2888896319 date "2018-08-01" @default.
• W2888896319 modified "2023-10-16" @default.
• W2888896319 title "Protective effects of 2,3,5,4‐tetrahydroxystilbene‐2‐o‐β‐D‐glucoside against osteoporosis: Current knowledge and proposed mechanisms" @default.
• W2888896319 cites W1005035362 @default.
• W2888896319 cites W1152201185 @default.
• W2888896319 cites W2018150954 @default.
• W2888896319 cites W2029608876 @default.
• W2888896319 cites W2032990401 @default.
• W2888896319 cites W2035618305 @default.
• W2888896319 cites W2045746575 @default.
• W2888896319 cites W2091331238 @default.
• W2888896319 cites W2096173332 @default.
• W2888896319 cites W2096465161 @default.
• W2888896319 cites W2097065948 @default.
• W2888896319 cites W2104005232 @default.
• W2888896319 cites W2107018762 @default.
• W2888896319 cites W2107281049 @default.
• W2888896319 cites W2128016314 @default.
• W2888896319 cites W2136850043 @default.
• W2888896319 cites W2139089901 @default.
• W2888896319 cites W2158217645 @default.
• W2888896319 cites W2159675211 @default.
• W2888896319 cites W2163341100 @default.
• W2888896319 cites W2171102198 @default.
• W2888896319 cites W2293595979 @default.
• W2888896319 cites W2413502283 @default.
• W2888896319 cites W2580163605 @default.
• W2888896319 cites W2733310964 @default.
• W2888896319 doi "https://doi.org/10.1111/1756-185x.13357" @default.
• W2888896319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30146742" @default.
• W2888896319 hasPublicationYear "2018" @default.
• W2888896319 type Work @default.
• W2888896319 sameAs 2888896319 @default.
• W2888896319 citedByCount "3" @default.
• W2888896319 countsByYear W28888963192020 @default.
• W2888896319 countsByYear W28888963192022 @default.
• W2888896319 countsByYear W28888963192023 @default.
• W2888896319 crossrefType "journal-article" @default.
• W2888896319 hasAuthorship W2888896319A5004331982 @default.
• W2888896319 hasAuthorship W2888896319A5027232307 @default.
• W2888896319 hasAuthorship W2888896319A5034977430 @default.
• W2888896319 hasAuthorship W2888896319A5035774966 @default.
• W2888896319 hasAuthorship W2888896319A5050304168 @default.
• W2888896319 hasAuthorship W2888896319A5063499064 @default.
• W2888896319 hasAuthorship W2888896319A5076306578 @default.
• W2888896319 hasAuthorship W2888896319A5084191075 @default.
• W2888896319 hasAuthorship W2888896319A5090318045 @default.
• W2888896319 hasConcept C104317684 @default.
• W2888896319 hasConcept C126322002 @default.
• W2888896319 hasConcept C13373296 @default.
• W2888896319 hasConcept C134018914 @default.
• W2888896319 hasConcept C137620995 @default.
• W2888896319 hasConcept C150194340 @default.
• W2888896319 hasConcept C152724338 @default.
• W2888896319 hasConcept C162317418 @default.
• W2888896319 hasConcept C190283241 @default.
• W2888896319 hasConcept C202751555 @default.
• W2888896319 hasConcept C2776151105 @default.
• W2888896319 hasConcept C2776541429 @default.
• W2888896319 hasConcept C2776914184 @default.
• W2888896319 hasConcept C2778260815 @default.
• W2888896319 hasConcept C502942594 @default.
• W2888896319 hasConcept C53227056 @default.
• W2888896319 hasConcept C55493867 @default.
• W2888896319 hasConcept C62478195 @default.
• W2888896319 hasConcept C71924100 @default.
• W2888896319 hasConcept C86803240 @default.
• W2888896319 hasConcept C95444343 @default.
• W2888896319 hasConceptScore W2888896319C104317684 @default.
• W2888896319 hasConceptScore W2888896319C126322002 @default.
• W2888896319 hasConceptScore W2888896319C13373296 @default.
• W2888896319 hasConceptScore W2888896319C134018914 @default.
• W2888896319 hasConceptScore W2888896319C137620995 @default.
• W2888896319 hasConceptScore W2888896319C150194340 @default.
• W2888896319 hasConceptScore W2888896319C152724338 @default.
• W2888896319 hasConceptScore W2888896319C162317418 @default.
• W2888896319 hasConceptScore W2888896319C190283241 @default.
• W2888896319 hasConceptScore W2888896319C202751555 @default.
• W2888896319 hasConceptScore W2888896319C2776151105 @default.
• W2888896319 hasConceptScore W2888896319C2776541429 @default.
• W2888896319 hasConceptScore W2888896319C2776914184 @default.
• W2888896319 hasConceptScore W2888896319C2778260815 @default.
• W2888896319 hasConceptScore W2888896319C502942594 @default.
• W2888896319 hasConceptScore W2888896319C53227056 @default.
• W2888896319 hasConceptScore W2888896319C55493867 @default.
• W2888896319 hasConceptScore W2888896319C62478195 @default.
• W2888896319 hasConceptScore W2888896319C71924100 @default.

• next