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• W2888897969 abstract "We reported the new sulphated polysaccharides, SJAMP and HLAMP that have been isolated from the sea cucumbers and compared their biological effects with those of standard heparin. (Med. J. Australia, 1986; 144: HS 17-21). SJAMP and HLAMP have an action that is independent of the antithrombin III and do not inhibit factor Xa, although they have potent antithrombin effect. SJAMP has been used as an antithrombin agent. As does heparin, SJAMP and HLAMP cause platelet aggregation of platelet-rich plasma. At the final concentration of SJAMP or HLAMP of 25μg/ml, a single wave of aggregation was observed.A second wave of aggregation can be induced at a concentration of SJAMP or HLAMP of 50μg/ml. In washed platelets, the platelet aggregation that was induced by SJAMP or HLAMP was fibrinogen-dependent. Furthermore ,plate let aggregation and the secretion of serotonin that is induced by ADP or arachidonic acid were enhanced by the prior addition of SJAMP or HLAMP.This effect may explain the cases of thrombocytopenia that may be observed in patients who are undergoing treatment with SJAMP. Using the monoclonal antibodies ( MoAb ) to human platelet glycoproteins (GP), we studied the SJAMP-p late let and heparin-platelet interactions. SZ-21 is a MoAb directed against GPIIIa and the epitope for SZ-21 is essential for the binding sites of fibrinogen on GPIIb/lIIa complex.SZ-2 is a MoAb to GPIb and recognize an epitope located on the peptide tail (Mr=35K) of the α-chain of GPIb. The platelet aggregation and the secretion of serotonin induced by SJAMP were inhibited by SZ-21, but not by SZ-2. However the preincubation of platelets with SJAMP at the final concentration of 25μg/ml or with heparin at 5μ/ml prevented the binding of radioiodinated-SZ-2 to human platelets. But SJAMP or heparin did not compete for the binding of radioiodinated-SZ-21 to human platelets. These results suggest that the platelet aggregation induced by SJAMP is dependent of the binding sites of fibrinogen on GPIIb/IIIa complex, and that the binding sites of SJAMP and heparin on human platelets are related with GPIb, but not with GPIIb/IIIa." @default.
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• W2888897969 date "1987-01-01" @default.
• W2888897969 modified "2023-09-23" @default.
• W2888897969 title "STUDIES ON THE INTERACTIONS BETWEEN THE HEPARIN-LIKE SUBSTANCES AND HUMAN PLATELETS USING THE MONOCLONAL ANTIBODIES TO PLATELET GLYCOPROTEINS" @default.
• W2888897969 doi "https://doi.org/10.1055/s-0038-1642871" @default.
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