Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888898836> ?p ?o ?g. }
- W2888898836 endingPage "1215" @default.
- W2888898836 startingPage "1208" @default.
- W2888898836 abstract "This study aimed to evaluate the potential of applying pectin and chitosan polysaccharides in pellet formulation. These biopolymers have advantages such as biocompatibility, low toxicity, low price and easy processing which make them interesting candidates for drug delivery purposes. Careful control of pellet porosity is essential to achieve an appropriate drug release profile. Replacing microcrystalline cellulose (MCC) with polysaccharides, especially pectin, leads to increased pellet porosity. Theophylline, dimenhydrinate and ibuprofen were chosen as model drugs. Investigation of possible ionic interactions between drugs and excipients is crucial to optimize the formulation of pellets with acceptable drug release. Differential scanning calorimetry of chitosan showed an endothermic peak; however, this peak was not observed in thermograms of the pectin, implying the lack of interaction between polysaccharides. Fourier transform infrared analysis did not indicate any interaction between drugs and polymers. Incorporation of MCC into the pellet formulation significantly increased the mean dissolution time while substitution of MCC with polysaccharides led to a faster release for each of the three drugs – that were different in their net charges – in both acidic and buffer media. These results highlight the potential value of polysaccharides in improving drug delivery characteristics of pharmaceutical pellets." @default.
- W2888898836 created "2018-09-07" @default.
- W2888898836 creator A5031444354 @default.
- W2888898836 creator A5038390046 @default.
- W2888898836 creator A5056284271 @default.
- W2888898836 creator A5056685607 @default.
- W2888898836 creator A5064455556 @default.
- W2888898836 creator A5064995978 @default.
- W2888898836 date "2018-12-01" @default.
- W2888898836 modified "2023-10-16" @default.
- W2888898836 title "Investigation of using pectin and chitosan as natural excipients in pellet formulation" @default.
- W2888898836 cites W1877301297 @default.
- W2888898836 cites W1878350755 @default.
- W2888898836 cites W1900818496 @default.
- W2888898836 cites W1963594544 @default.
- W2888898836 cites W1969594423 @default.
- W2888898836 cites W1970255141 @default.
- W2888898836 cites W1971335282 @default.
- W2888898836 cites W1971670304 @default.
- W2888898836 cites W1972324363 @default.
- W2888898836 cites W1985841452 @default.
- W2888898836 cites W1988024075 @default.
- W2888898836 cites W1989403110 @default.
- W2888898836 cites W1990260443 @default.
- W2888898836 cites W1994008807 @default.
- W2888898836 cites W1994145813 @default.
- W2888898836 cites W2002884324 @default.
- W2888898836 cites W2012909287 @default.
- W2888898836 cites W2015197471 @default.
- W2888898836 cites W2019775007 @default.
- W2888898836 cites W2030393722 @default.
- W2888898836 cites W2031285506 @default.
- W2888898836 cites W2034765332 @default.
- W2888898836 cites W2038062954 @default.
- W2888898836 cites W2040217299 @default.
- W2888898836 cites W2040457758 @default.
- W2888898836 cites W2042892741 @default.
- W2888898836 cites W2043990601 @default.
- W2888898836 cites W2044231361 @default.
- W2888898836 cites W2044792974 @default.
- W2888898836 cites W2054932714 @default.
- W2888898836 cites W2055128518 @default.
- W2888898836 cites W2055151230 @default.
- W2888898836 cites W2063454088 @default.
- W2888898836 cites W2066497079 @default.
- W2888898836 cites W2071137515 @default.
- W2888898836 cites W2081052678 @default.
- W2888898836 cites W2084783077 @default.
- W2888898836 cites W2086947055 @default.
- W2888898836 cites W2087506238 @default.
- W2888898836 cites W2087544381 @default.
- W2888898836 cites W2089248849 @default.
- W2888898836 cites W2108031998 @default.
- W2888898836 cites W2115538851 @default.
- W2888898836 cites W2131945662 @default.
- W2888898836 cites W2134168039 @default.
- W2888898836 cites W2135579715 @default.
- W2888898836 cites W230458012 @default.
- W2888898836 cites W2306650882 @default.
- W2888898836 cites W2740666812 @default.
- W2888898836 cites W2758711284 @default.
- W2888898836 cites W2775329371 @default.
- W2888898836 cites W2802864841 @default.
- W2888898836 cites W406697269 @default.
- W2888898836 doi "https://doi.org/10.1016/j.ijbiomac.2018.08.129" @default.
- W2888898836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30165148" @default.
- W2888898836 hasPublicationYear "2018" @default.
- W2888898836 type Work @default.
- W2888898836 sameAs 2888898836 @default.
- W2888898836 citedByCount "16" @default.
- W2888898836 countsByYear W28888988362019 @default.
- W2888898836 countsByYear W28888988362020 @default.
- W2888898836 countsByYear W28888988362021 @default.
- W2888898836 countsByYear W28888988362022 @default.
- W2888898836 countsByYear W28888988362023 @default.
- W2888898836 crossrefType "journal-article" @default.
- W2888898836 hasAuthorship W2888898836A5031444354 @default.
- W2888898836 hasAuthorship W2888898836A5038390046 @default.
- W2888898836 hasAuthorship W2888898836A5056284271 @default.
- W2888898836 hasAuthorship W2888898836A5056685607 @default.
- W2888898836 hasAuthorship W2888898836A5064455556 @default.
- W2888898836 hasAuthorship W2888898836A5064995978 @default.
- W2888898836 hasConcept C100817775 @default.
- W2888898836 hasConcept C121332964 @default.
- W2888898836 hasConcept C127413603 @default.
- W2888898836 hasConcept C159985019 @default.
- W2888898836 hasConcept C178790620 @default.
- W2888898836 hasConcept C17923525 @default.
- W2888898836 hasConcept C185592680 @default.
- W2888898836 hasConcept C192562407 @default.
- W2888898836 hasConcept C2779251873 @default.
- W2888898836 hasConcept C2779351475 @default.
- W2888898836 hasConcept C2779732960 @default.
- W2888898836 hasConcept C2779820397 @default.
- W2888898836 hasConcept C2780756937 @default.
- W2888898836 hasConcept C31903555 @default.
- W2888898836 hasConcept C39519442 @default.
- W2888898836 hasConcept C42360764 @default.