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• W2888942775 startingPage "9604" @default.
• W2888942775 abstract "T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for Tfh cells but is debated for Tfr cells. Here, we used high-throughput T cell receptor (TCR) sequencing to analyze the repertoires of Tfh and Tfr cells, at homeostasis and after immunization with self- or foreign antigens. We observed that, whatever the conditions, Tfh and Tfr cell repertoires are less diverse than those of effector T cells and Treg cells of the same tissues; surprisingly, these repertoires still represent thousands of different sequences, even after immunization with a single antigen that induces a 10-fold increase in Tfol cell numbers. Thorough analysis of the sharing and network of TCR sequences revealed that a specific response to the immunizing antigen can only, but hardly, be detected in Tfh cells immunized with a foreign antigen and Tfr cells immunized with a self-antigen. These antigen-specific responses are obscured by a global stimulation of Tfh and Tfr cells that appears to be antigen-independent. Altogether, our results suggest a major bystander Tfol cell activation during the immune response in the GCs." @default.
• W2888942775 created "2018-09-07" @default.
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• W2888942775 date "2018-08-29" @default.
• W2888942775 modified "2023-10-10" @default.
• W2888942775 title "High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells" @default.
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• W2888942775 doi "https://doi.org/10.1073/pnas.1808594115" @default.
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• W2888942775 hasPublicationYear "2018" @default.
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