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- W2888948414 abstract "Factor XIII catalyzed the formation of gels in solutions containing physiological concentrations of fibrinogen and fibro-nectin. Oligomeric intermediates were isolated from reaction mixtures at early times prior to gel formation by chromatography on gelatin-Sepharose and by FPLC using Superose 6 columns. The products of two simultaneous polymerization reactions were characterized: fibrinogen oligomers (fibrinogenin) from the poly merization of fibrinogen, and conjugates of fibrinogen-fibro-nectin (heteronectin) from heteropolymer formation involving the two proteins. At a constant concentration of fibrinogen (2.5 mg/mL) and factor XIII (0.4 U/mL), the appearance of different sizes of fibrinogen polymers depended on the concentration of fibronectin added to the reaction mixture. At fibronectin concentrations in the range of the normal plasma level of 0.3 mg/mL, fibrinogen formed oligomers of various sizes up to heptamer before incorporating a molecule of fibronectin. At a high fibronectin concentration (3.2 mg/mL) most of the fibrinogen reacted with the fibronectin at the monomer stage, although small amounts of fibrinogen dimers and trimers were also formed. Heteronectin formation coincided with the appearance of filamentous and particulate matter. This material became incorporated into a gel structure if sufficient fibrinogen was present in the reaction mixture (about 0.5 mg/mL). If these factor XIII catalyzed polymerization reactions occur in the microvasculature under conditions where the fibrinogen concentration might be significantly lowered, the production of fibrinogen-fibronectin polymeric material without gel formation would be favored." @default.
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- W2888948414 date "1987-01-01" @default.
- W2888948414 modified "2023-10-01" @default.
- W2888948414 title "POLYMERIZATION OF FIBRINOGEN AND FIBRONECTIN CATALYZED BY FACTOR XIII." @default.
- W2888948414 doi "https://doi.org/10.1055/s-0038-1643310" @default.
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