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• W2888953208 abstract "Lack of animal model of radiation induced muscle fibrosis, this study aimed to establish such a model by using 90 Gy single dose irradiation to mimic clinical relevance and also to explore the potential post-irradiation regenerative mechanism.SD rats were randomly divided into dose investigation groups and time gradient groups. Group1-6 were irradiated with a single dose of 65Gy, 70Gy, 75Gy, 80Gy, 85Gy and 90Gy respectively, and the degree of rectus femoris fibrosis in the irradiated area was detected at 4 weeks after irradiation. Group 7-9 were irradiated with a single dose of 90Gy, and the results were detected 1, 2, 4, and 8 weeks after irradiation. Then the general condition of rats was recorded. Masson staining was used to detect muscle fibrosis. The ultrastructure of muscles was observed by electron microscope, and the expression changes of satellite cell proliferation and differentiation related genes were detected by quantitative real-time-PCR.A single dose of 90Gy irradiation could cause muscle fibrosis in rats. As time goes on, the severity of muscle fibrosis and the expression of TGF- β1 increased. Significant swelling of mitochondria, myofilament disarrangement and dissolution, obvious endothelial cell swelling, increased vascular permeability, decrease of blood cell, deposition of fibrosis tissue around the vessel could be found compared with the control group. At around the 4th week, the expressions of Pax7, Myf5, MyoD, MyoG, Mrf4 increased.Irradiation of 90Gy can successfully establish the rat model of radiation-induced muscle fibrosis. This model demonstrated that regenerative process was initiated by the irradiation only at an early stage, which can serve a suitable model for investigating regenerative therapy for post-radiation muscle fibrosis." @default.
• W2888953208 created "2018-09-07" @default.
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• W2888953208 date "2018-08-29" @default.
• W2888953208 modified "2023-09-30" @default.
• W2888953208 title "Radiation-induced muscle fibrosis rat model: establishment and valuation" @default.
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• W2888953208 cites W1964113973 @default.
• W2888953208 cites W1964269632 @default.
• W2888953208 cites W1968477506 @default.
• W2888953208 cites W1979120073 @default.
• W2888953208 cites W1980325398 @default.
• W2888953208 cites W1981095724 @default.
• W2888953208 cites W1983357763 @default.
• W2888953208 cites W1986377016 @default.
• W2888953208 cites W1986583100 @default.
• W2888953208 cites W1987936572 @default.
• W2888953208 cites W1988916713 @default.
• W2888953208 cites W1989169469 @default.
• W2888953208 cites W1990763843 @default.
• W2888953208 cites W1995983948 @default.
• W2888953208 cites W1997639385 @default.
• W2888953208 cites W2001099533 @default.
• W2888953208 cites W2004898676 @default.
• W2888953208 cites W2005766554 @default.
• W2888953208 cites W2008771785 @default.
• W2888953208 cites W2013464812 @default.
• W2888953208 cites W2017025391 @default.
• W2888953208 cites W2019101092 @default.
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• W2888953208 cites W2029914169 @default.
• W2888953208 cites W2030185151 @default.
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• W2888953208 cites W2044351980 @default.
• W2888953208 cites W2050004291 @default.
• W2888953208 cites W2050196300 @default.
• W2888953208 cites W2063745876 @default.
• W2888953208 cites W2076354639 @default.
• W2888953208 cites W2077429419 @default.
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• W2888953208 cites W2081908301 @default.
• W2888953208 cites W2088021312 @default.
• W2888953208 cites W2088930918 @default.
• W2888953208 cites W2090007565 @default.
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• W2888953208 cites W2113182329 @default.
• W2888953208 cites W2118533478 @default.
• W2888953208 cites W2118622207 @default.
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• W2888953208 cites W2612749342 @default.
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• W2888953208 doi "https://doi.org/10.1186/s13014-018-1104-0" @default.
• W2888953208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6114061" @default.
• W2888953208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30157899" @default.
• W2888953208 hasPublicationYear "2018" @default.
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