FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888960892> ?p ?o ?g. }

• W2888960892 endingPage "269" @default.
• W2888960892 startingPage "261" @default.
• W2888960892 abstract "Helicobacter pylori infects the gastric epithelium of half the global population, where infections can persist into adenocarcinomas and peptic ulcers. H. pylori secretes several proteins that lend to its pathogenesis and survival including VacA, CagA, γ-glutamyltransferase and HP0175. HP0175, also known as HpCBF2, classified as a peptidyl-prolyl cis,trans-isomerase, has been shown to induce apoptosis through a cascade of mechanisms initiated though its interaction with toll like receptor 4 (TLR4). Here, we report the structure of apo-HP0175 at 2.09 Å with a single monomer in the asymmetric unit. Chromatographic, light scattering and mass spectrometric analysis of HP0175 in solution indicate that the protein is mainly monomeric under low salt conditions, while increasing ionic interactions facilitates protein dimerization. A comparison of the apo-HP0175 structure to that of the indole-2-carboxylic acid-bound form shows movement of the N- and C-terminal helices upon interaction of the catalytic residues in the binding pocket. Helix extension of the N/C chaperone domains between apo and I2CA-bound HP0175 supports previous findings in parvulin PPIases for their role in protein stabilization (and accommodation of variable protein lengths) of those undergoing catalysis." @default.
• W2888960892 created "2018-09-07" @default.
• W2888960892 creator A5043232229 @default.
• W2888960892 creator A5073946426 @default.
• W2888960892 date "2018-11-01" @default.
• W2888960892 modified "2023-09-28" @default.
• W2888960892 title "Structural flexibility in the Helicobacter pylori peptidyl-prolyl cis,trans-isomerase HP0175 is achieved through an extension of the chaperone helices" @default.
• W2888960892 cites W1488136969 @default.
• W2888960892 cites W1967918248 @default.
• W2888960892 cites W1976132432 @default.
• W2888960892 cites W1977038370 @default.
• W2888960892 cites W1977536637 @default.
• W2888960892 cites W1986125788 @default.
• W2888960892 cites W1987269580 @default.
• W2888960892 cites W1987774012 @default.
• W2888960892 cites W1988868441 @default.
• W2888960892 cites W1992336441 @default.
• W2888960892 cites W1994342014 @default.
• W2888960892 cites W1997681612 @default.
• W2888960892 cites W1999483841 @default.
• W2888960892 cites W2001747259 @default.
• W2888960892 cites W2005094260 @default.
• W2888960892 cites W2009284411 @default.
• W2888960892 cites W2009650104 @default.
• W2888960892 cites W2014694459 @default.
• W2888960892 cites W2019721868 @default.
• W2888960892 cites W2025438577 @default.
• W2888960892 cites W2029499500 @default.
• W2888960892 cites W2036023470 @default.
• W2888960892 cites W2038646712 @default.
• W2888960892 cites W2049815305 @default.
• W2888960892 cites W2055176898 @default.
• W2888960892 cites W2066088601 @default.
• W2888960892 cites W2082195409 @default.
• W2888960892 cites W2082747164 @default.
• W2888960892 cites W2084566089 @default.
• W2888960892 cites W2088902653 @default.
• W2888960892 cites W2089850443 @default.
• W2888960892 cites W2090640877 @default.
• W2888960892 cites W2094201044 @default.
• W2888960892 cites W2098174442 @default.
• W2888960892 cites W2108921801 @default.
• W2888960892 cites W2110680433 @default.
• W2888960892 cites W2113675798 @default.
• W2888960892 cites W2119416327 @default.
• W2888960892 cites W2120029008 @default.
• W2888960892 cites W2122994276 @default.
• W2888960892 cites W2124026197 @default.
• W2888960892 cites W2125743541 @default.
• W2888960892 cites W2127130852 @default.
• W2888960892 cites W2127322768 @default.
• W2888960892 cites W2127934565 @default.
• W2888960892 cites W2131123265 @default.
• W2888960892 cites W2152811683 @default.
• W2888960892 cites W2154197653 @default.
• W2888960892 cites W2159211495 @default.
• W2888960892 cites W2160090073 @default.
• W2888960892 cites W2163341755 @default.
• W2888960892 cites W2180229411 @default.
• W2888960892 cites W2257116612 @default.
• W2888960892 cites W2309257471 @default.
• W2888960892 cites W2505248807 @default.
• W2888960892 cites W2528451823 @default.
• W2888960892 cites W2707646777 @default.
• W2888960892 cites W2765465714 @default.
• W2888960892 cites W2765669185 @default.
• W2888960892 cites W4248872320 @default.
• W2888960892 doi "https://doi.org/10.1016/j.jsb.2018.08.017" @default.
• W2888960892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30179659" @default.
• W2888960892 hasPublicationYear "2018" @default.
• W2888960892 type Work @default.
• W2888960892 sameAs 2888960892 @default.
• W2888960892 citedByCount "4" @default.
• W2888960892 countsByYear W28889608922019 @default.
• W2888960892 countsByYear W28889608922020 @default.
• W2888960892 countsByYear W28889608922022 @default.
• W2888960892 countsByYear W28889608922023 @default.
• W2888960892 crossrefType "journal-article" @default.
• W2888960892 hasAuthorship W2888960892A5043232229 @default.
• W2888960892 hasAuthorship W2888960892A5073946426 @default.
• W2888960892 hasConcept C142724271 @default.
• W2888960892 hasConcept C144024400 @default.
• W2888960892 hasConcept C149923435 @default.
• W2888960892 hasConcept C166940927 @default.
• W2888960892 hasConcept C178790620 @default.
• W2888960892 hasConcept C181199279 @default.
• W2888960892 hasConcept C185592680 @default.
• W2888960892 hasConcept C2775962898 @default.
• W2888960892 hasConcept C2776409635 @default.
• W2888960892 hasConcept C2781264208 @default.
• W2888960892 hasConcept C2908647359 @default.
• W2888960892 hasConcept C521977710 @default.
• W2888960892 hasConcept C54355233 @default.
• W2888960892 hasConcept C55493867 @default.
• W2888960892 hasConcept C71240020 @default.
• W2888960892 hasConcept C71924100 @default.
• W2888960892 hasConcept C86803240 @default.
• W2888960892 hasConceptScore W2888960892C142724271 @default.

• next