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- W2888965306 abstract "Objective: The primary focus of this review is to highlight the current and emerging proinflammatory role of MK2 kinase signaling in p38MAPK pathway and to provide a detailed evaluation on the prospects of MK2 inhibition with special emphasis on the etiology of chronic inflammatory airway diseases, such as asthma, idiopathic pulmonary fibrosis, lung cancer, acute lung injury and acute respiratory distress syndrome. Background: MK2 belongs to serine-threonine kinase family and is activated directly by stress and inflammatory signal through p38MAPK phosphorylation in diverse inflammatory conditions through the Toll-like receptor signaling pathway. MK2 has been thought to be a critical factor involved in the regulation of synthesis and release of pro-inflammatory (TNF-α, IL-6 and IL-1β, etc.) proteins. Targeted inhibition of MK2 kinase has been shown to significantly reduce the production and release of these cytokine molecules. Therefore, MK2 has been identified as an effective strategy (alternative to p38MAPK) to block this pro-inflammatory signaling pathway. Results: The inhibition of MK2 may lead to similar or better efficacy as that of p38 inhibitors, and interestingly avoids the systemic toxicity shown by the p38 inhibitors. Thus, MK2 has been the focus of intense interdisciplinary research and its specific inhibition can be a novel and potential therapeutic strategy for the treatment of chronic airway inflammatory diseases. Conclusion: Promising advancement in understanding and rigorous exploration of the role of MK2 kinase in inflammatory processes may contribute to the development of newer and safer therapy for the treatment of chronic airway inflammatory diseases in the future." @default.
- W2888965306 created "2018-09-07" @default.
- W2888965306 creator A5023024286 @default.
- W2888965306 creator A5076704178 @default.
- W2888965306 date "2019-01-25" @default.
- W2888965306 modified "2023-09-24" @default.
- W2888965306 title "Novel Therapeutic Potential of Mitogen-Activated Protein Kinase Activated Protein Kinase 2 (MK2) in Chronic Airway Inflammatory Disorders" @default.
- W2888965306 cites W1481604795 @default.
- W2888965306 cites W1535218665 @default.
- W2888965306 cites W1555014582 @default.
- W2888965306 cites W1587498640 @default.
- W2888965306 cites W1611014326 @default.
- W2888965306 cites W1902683402 @default.
- W2888965306 cites W1969324401 @default.
- W2888965306 cites W1970120381 @default.
- W2888965306 cites W1974353473 @default.
- W2888965306 cites W1977399054 @default.
- W2888965306 cites W1982123744 @default.
- W2888965306 cites W1983046473 @default.
- W2888965306 cites W1984238920 @default.
- W2888965306 cites W1985272590 @default.
- W2888965306 cites W1996992763 @default.
- W2888965306 cites W1997255681 @default.
- W2888965306 cites W1999207367 @default.
- W2888965306 cites W2000015350 @default.
- W2888965306 cites W2003288227 @default.
- W2888965306 cites W2012192150 @default.
- W2888965306 cites W2014859793 @default.
- W2888965306 cites W2017795530 @default.
- W2888965306 cites W2018712671 @default.
- W2888965306 cites W2028407122 @default.
- W2888965306 cites W2030688800 @default.
- W2888965306 cites W2031850887 @default.
- W2888965306 cites W2032019019 @default.
- W2888965306 cites W2033320490 @default.
- W2888965306 cites W2034611095 @default.
- W2888965306 cites W2036039462 @default.
- W2888965306 cites W2036606290 @default.
- W2888965306 cites W2039099155 @default.
- W2888965306 cites W2040879422 @default.
- W2888965306 cites W2042450501 @default.
- W2888965306 cites W2044175451 @default.
- W2888965306 cites W2044959738 @default.
- W2888965306 cites W2048895915 @default.
- W2888965306 cites W2051557275 @default.
- W2888965306 cites W2052214665 @default.
- W2888965306 cites W2052397527 @default.
- W2888965306 cites W2053440052 @default.
- W2888965306 cites W2056171538 @default.
- W2888965306 cites W2058839898 @default.
- W2888965306 cites W2061903681 @default.
- W2888965306 cites W2062010118 @default.
- W2888965306 cites W2062041300 @default.
- W2888965306 cites W2062340794 @default.
- W2888965306 cites W2063701247 @default.
- W2888965306 cites W2066587329 @default.
- W2888965306 cites W2071467777 @default.
- W2888965306 cites W2074267409 @default.
- W2888965306 cites W2079749507 @default.
- W2888965306 cites W2081820616 @default.
- W2888965306 cites W2083960052 @default.
- W2888965306 cites W2084365684 @default.
- W2888965306 cites W2085121068 @default.
- W2888965306 cites W2086655427 @default.
- W2888965306 cites W2092382665 @default.
- W2888965306 cites W2093379009 @default.
- W2888965306 cites W2102288730 @default.
- W2888965306 cites W2103079623 @default.
- W2888965306 cites W2103921882 @default.
- W2888965306 cites W2106591690 @default.
- W2888965306 cites W2107495112 @default.
- W2888965306 cites W2109862246 @default.
- W2888965306 cites W2110477696 @default.
- W2888965306 cites W2115162045 @default.
- W2888965306 cites W2115341926 @default.
- W2888965306 cites W2116164922 @default.
- W2888965306 cites W2123524671 @default.
- W2888965306 cites W2126149301 @default.
- W2888965306 cites W2127156531 @default.
- W2888965306 cites W2127264152 @default.
- W2888965306 cites W2127551467 @default.
- W2888965306 cites W2130438035 @default.
- W2888965306 cites W2133300954 @default.
- W2888965306 cites W2135133228 @default.
- W2888965306 cites W2138336407 @default.
- W2888965306 cites W2139139966 @default.
- W2888965306 cites W2144911970 @default.
- W2888965306 cites W2145970982 @default.
- W2888965306 cites W2146510390 @default.
- W2888965306 cites W2155502203 @default.
- W2888965306 cites W2155770438 @default.
- W2888965306 cites W2157068896 @default.
- W2888965306 cites W2161383908 @default.
- W2888965306 cites W2168831955 @default.
- W2888965306 cites W2171177609 @default.
- W2888965306 cites W2293547975 @default.
- W2888965306 cites W2342992511 @default.
- W2888965306 cites W2395030726 @default.