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- W2888981207 abstract "We studied 31 patients with monoclonal gammopathy (MG), 10 of them secreting monoclonal antibodies (MoAb) of the G class, 13 of them IgM and 8 IgA. We also studied 15 healthy age- and sex-matched control subjects. On each subject we evaluated whole blood aggregation (WBA) in response to ADP, collagen, epinephrine and arachidonic acid in parallel with PRP aggregation according to the method of Born. We wondered whether WBA could provide us further information on the interference of MoAb on platelet function. Agonists and concentrations which yielded statistically significant results in comparison with controls will be reported. IgM MG: Increased WBA to epinephrine 5 and 10 μM (p < 0.01) and ADP 4 and 6 μM (p < 0.001). Increased PRP aggregation to ADP 1 μM (p < 0.001) and collagen 1 μg/ml (p < 0.001). IgA MG: increased WBA to ADP 1 μM (p < 0.001). No difference in PRP aggregation. IgG MG: no difference in WBA. Reduced PRP aggregation in response to ADP 1 μM (p < 0.01) and arachidonic acid 0.5 mM (p < 0.01). We conclude that high molecular weight Ig (IgM pentamers and IgA dimers) seem to play a role in WBA, causing an increased aggregatory response when measured as impedance variation; on the other hand, low molecular weight Ig (IgG) seem to interfere directly with platelet function, causing a decreased aggregation. The mechanism underlying this phenomenon is still unclear. Supported by Grant n° 13 by Regione Piemonte." @default.
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- W2888981207 date "1987-01-01" @default.
- W2888981207 modified "2023-09-27" @default.
- W2888981207 title "INTERFERENCE OF MONOCLONAL IMMUNOGLOBULINS ON PLATELETS AND WHOLE BLOOD AGGREGATION" @default.
- W2888981207 doi "https://doi.org/10.1055/s-0038-1643195" @default.
- W2888981207 hasPublicationYear "1987" @default.
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