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• W2889002011 abstract "Bovine platelet a-granule acid extract (BPAE) contains vascular permeability factor (VPF) as human platelets. VPF plays as a mediator depending on polymorphonuclear (PMN) leukocytes and possesses a potent cell growth activity in cultured fibroblasts. This study was carried out to examine the chemotactic activity of VPF for PMN leukocytes of rabbits. For the study of chemotaxis, the PMN leukocytes were collected from the ascites after production by an injection of 0.1% oyster glycogen in 0.85% NaCl solution into the peritoneal cavity of rabbits. They were suspended in the Gey's balanced salt solution with supplementation of 2% human albumin. Partial purification of BPAE was performed by gel filteration using Sephadex G-50 so as to exclude the influence of PF-4 and 8-TG. BPAE, as the attractant solution, was prepared at the several concentration in the Gey's solution. Human serum activated with zymosan was used as the positive control. Effects of protamine sulfate, a competitive inhibitor of platelet-derived growth factor (PDGF), on the chemotactic activity of VPF were also studied. Chemotaxis of the PMN leukocytes was measured in the modified Boyden chamber with a 3jJm-pore filter. Five high power (x400) grids were counted per filter and cell migration was corrected by subtraction of blanks in which the lower compartment contained medium only. The most striking chemotactic response was obtained when BPAE was used at the concentration of 0.1μg/ml. However, the response was reduced at the concentration of more than 1μg/ml. The activity of BPAE (0.1μg/ml) was about 60% of the positive control level. The migration was reduced to 18% of the positive control by protamine sulfate (3μg/ml) at that concentration of BPAE It is concluded that VPF induces chemotaxis to PMN leukocytes at the concentration lesser than that enhancing the vascular permeability response. Furthermore, protamine sulfate inhibits the VPF-induced migration of PMN leukocytes. Those findings may indicate that VPF acts as PDGF in function. Therefore, it is likely that the factor attracts PMN leukocytes and promotes cell growth in the inflamed region" @default.
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• W2889002011 date "1987-01-01" @default.
• W2889002011 modified "2023-09-23" @default.
• W2889002011 title "CHEMOTAXIS OF POLYMORPHONUCLEAR LEUKOCYTES BY VASCULAR PERMEABILITY FACTOR FROM BOVINE PLATELETS" @default.
• W2889002011 doi "https://doi.org/10.1055/s-0038-1643164" @default.
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