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- W2889005164 abstract "The bacterial nucleoid is highly condensed and forms compartment-like structures within the cell. Much attention has been devoted to investigating the dynamic topology and organization of the nucleoid. In contrast, the specific nucleoid organization, and the relationship between nucleoid structure and function is often neglected with regard to importance for adaption to changing environments and horizontal gene acquisition. In this review, we focus on the structure-function relationship in the bacterial nucleoid. We provide an overview of the fundamental properties that shape the chromosome as a structured yet dynamic macromolecule. These fundamental properties are then considered in the context of the living cell, with focus on how the informational flow affects the nucleoid structure, which in turn impacts on the genetic output. Subsequently, the dynamic living nucleoid will be discussed in the context of evolution. We will address how the acquisition of foreign DNA impacts nucleoid structure, and conversely, how nucleoid structure constrains the successful and sustainable chromosomal integration of novel DNA. Finally, we will discuss current challenges and directions of research in understanding the role of chromosomal architecture in bacterial survival and adaptation." @default.
- W2889005164 created "2018-09-07" @default.
- W2889005164 creator A5011220682 @default.
- W2889005164 creator A5073977487 @default.
- W2889005164 creator A5075352543 @default.
- W2889005164 date "2018-08-27" @default.
- W2889005164 modified "2023-09-29" @default.
- W2889005164 title "Impact of Chromosomal Architecture on the Function and Evolution of Bacterial Genomes" @default.
- W2889005164 cites W1548784612 @default.
- W2889005164 cites W1598985695 @default.
- W2889005164 cites W1828765245 @default.
- W2889005164 cites W1853950746 @default.
- W2889005164 cites W1917921565 @default.
- W2889005164 cites W1953757982 @default.
- W2889005164 cites W1954220281 @default.
- W2889005164 cites W1965562485 @default.
- W2889005164 cites W1967531530 @default.
- W2889005164 cites W1968854638 @default.
- W2889005164 cites W1972168116 @default.
- W2889005164 cites W1976847457 @default.
- W2889005164 cites W1979020653 @default.
- W2889005164 cites W1979778946 @default.
- W2889005164 cites W1982155053 @default.
- W2889005164 cites W1985886752 @default.
- W2889005164 cites W1985963323 @default.
- W2889005164 cites W1986847472 @default.
- W2889005164 cites W1991104796 @default.
- W2889005164 cites W1994919128 @default.
- W2889005164 cites W1999312936 @default.
- W2889005164 cites W1999474945 @default.
- W2889005164 cites W2000137398 @default.
- W2889005164 cites W2001162607 @default.
- W2889005164 cites W2005318857 @default.
- W2889005164 cites W2008270769 @default.
- W2889005164 cites W2009715778 @default.
- W2889005164 cites W2013430210 @default.
- W2889005164 cites W2016160555 @default.
- W2889005164 cites W2019296317 @default.
- W2889005164 cites W2022189854 @default.
- W2889005164 cites W2025830975 @default.
- W2889005164 cites W2030685648 @default.
- W2889005164 cites W2032464841 @default.
- W2889005164 cites W2032769021 @default.
- W2889005164 cites W2033623058 @default.
- W2889005164 cites W2037451631 @default.
- W2889005164 cites W2038844863 @default.
- W2889005164 cites W2041949408 @default.
- W2889005164 cites W2042686872 @default.
- W2889005164 cites W2046892161 @default.
- W2889005164 cites W2049588263 @default.
- W2889005164 cites W2051822822 @default.
- W2889005164 cites W2052094781 @default.
- W2889005164 cites W2053243729 @default.
- W2889005164 cites W2053751543 @default.
- W2889005164 cites W2055214702 @default.
- W2889005164 cites W2056892325 @default.
- W2889005164 cites W2060177007 @default.
- W2889005164 cites W2066110691 @default.
- W2889005164 cites W2067088861 @default.
- W2889005164 cites W2072479766 @default.
- W2889005164 cites W2083788527 @default.
- W2889005164 cites W2085223420 @default.
- W2889005164 cites W2086520403 @default.
- W2889005164 cites W2093777918 @default.
- W2889005164 cites W2095481462 @default.
- W2889005164 cites W2096047458 @default.
- W2889005164 cites W2096926750 @default.
- W2889005164 cites W2097557319 @default.
- W2889005164 cites W2098021788 @default.
- W2889005164 cites W2101058845 @default.
- W2889005164 cites W2101322984 @default.
- W2889005164 cites W2101425827 @default.
- W2889005164 cites W2102707800 @default.
- W2889005164 cites W2104042038 @default.
- W2889005164 cites W2107888921 @default.
- W2889005164 cites W2109811392 @default.
- W2889005164 cites W2109923997 @default.
- W2889005164 cites W2110755993 @default.
- W2889005164 cites W2111386013 @default.
- W2889005164 cites W2111745935 @default.
- W2889005164 cites W2113067014 @default.
- W2889005164 cites W2113555445 @default.
- W2889005164 cites W2117208578 @default.
- W2889005164 cites W2118924991 @default.
- W2889005164 cites W2119077619 @default.
- W2889005164 cites W2124983475 @default.
- W2889005164 cites W2126466006 @default.
- W2889005164 cites W2134346985 @default.
- W2889005164 cites W2137419453 @default.
- W2889005164 cites W2138952930 @default.
- W2889005164 cites W2141952839 @default.
- W2889005164 cites W2146496997 @default.
- W2889005164 cites W2147057508 @default.
- W2889005164 cites W2148728220 @default.
- W2889005164 cites W2153326344 @default.
- W2889005164 cites W2153962977 @default.
- W2889005164 cites W2154407985 @default.
- W2889005164 cites W2154680970 @default.
- W2889005164 cites W2155359871 @default.
- W2889005164 cites W2155751070 @default.