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- W2889018398 abstract "Karyotyping along with a 3-probe fluorescence in situ hybridization (FISH) strategy was used to risk stratify therapy in 303 children with B-cell precursor acute lymphoblastic leukaemia. Of the 166 patients risk stratified, karyotype identified 91 (55%). FISH identified all karyotypes accurately, with the exception of hypodiploidy, and risk stratified an additional 75 patients. The frequency of ETV6-RUNX1 is lower and high hyperdiploidy, higher than reported in the west. An adapted 3-probe FISH strategy identified two patients with ETV6-ABL1 fusion who received imatinib. In limited-resource settings, a 3-probe FISH approach provides a practical approach for risk-stratified therapy in childhood ALL." @default.
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- W2889018398 date "2018-08-31" @default.
- W2889018398 modified "2023-10-15" @default.
- W2889018398 title "A triple‐probe FISH screening strategy for risk‐stratified therapy of acute lymphoblastic leukaemia in low‐resource settings" @default.
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- W2889018398 doi "https://doi.org/10.1002/pbc.27366" @default.
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