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- W2889022330 abstract "In 1972 Neal Bricker presented the trade-off hypothesis in which he detailed the role of physiological adaptation processes in mediating some of the pathophysiology associated with declines in renal function. In the late 1990's Xie and Askari published seminal studies indicating that the Na⁺/K⁺-ATPase (NKA) was not only an ion pump, but also a signal transducer that interacts with several signaling partners. Since this discovery, numerous studies from multiple laboratories have shown that the NKA is a central player in mediating some of these long-term trade-offs of the physiological adaptation processes which Bricker originally proposed in the 1970's. In fact, NKA ligands such as cardiotonic steroids (CTS), have been shown to signal through NKA, and consequently been implicated in mediating both adaptive and maladaptive responses to volume overload such as fibrosis and oxidative stress. In this review we will emphasize the role the NKA plays in this trade-off with respect to CTS signaling and its implication in inflammation and fibrosis in target organs including the heart, kidney, and vasculature. As inflammation and fibrosis exhibit key roles in the pathogenesis of a number of clinical disorders such as chronic kidney disease, heart failure, atherosclerosis, obesity, preeclampsia, and aging, this review will also highlight the role of newly discovered NKA signaling partners in mediating some of these conditions." @default.
- W2889022330 created "2018-09-07" @default.
- W2889022330 creator A5001114788 @default.
- W2889022330 creator A5016178402 @default.
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- W2889022330 creator A5038688992 @default.
- W2889022330 creator A5044448931 @default.
- W2889022330 creator A5053114065 @default.
- W2889022330 date "2018-08-30" @default.
- W2889022330 modified "2023-10-05" @default.
- W2889022330 title "Cardiotonic Steroids and the Sodium Trade Balance: New Insights into Trade-Off Mechanisms Mediated by the Na+/K+-ATPase" @default.
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