FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889059065> ?p ?o ?g. }

• W2889059065 endingPage "363" @default.
• W2889059065 startingPage "356" @default.
• W2889059065 abstract "Clodronate is prescribed to performance horses with lameness. Despite its clinical popularity, little research has been done to understand the effects of clodronate in the horse.Our objective was to determine if a single treatment with clodronate at the clinically approved dose altered bone remodelling, bone cell recruitment or lameness in the horse.Twelve university-owned equestrian team competition horses with a history of forelimb lameness due to navicular syndrome were randomised to receive either 1.4 mg/kg clodronate (CLOD n = 6) or an equivalent volume of LRS (CONT; n = 6) in a blinded manner.Blood was evaluated weekly for 8 weeks before and after drug administration (clodronate or placebo) for bone turnover markers CTX-I and osteocalcin. Lameness evaluations were performed to assess for change in lameness 1 week before and 1, 2, 3 and 8 weeks after drug administration. Coach questionnaires were performed to assess for change in ridden performance 1, 2, 3 and 8 weeks after drug administration. Bone cell recruitment was evaluated in vitro 2 weeks before and after drug administration.There were no differences in in vitro bone cell recruitment from whole bone marrow or in bone turnover markers CTX-I or osteocalcin. A small but significant decrease in forelimb lameness was detected in CLOD treated horses 1 week after treatment (P = 0.005). There were no significant differences in hindlimb lameness. Coaches identified an improvement in performance significantly more often in CLOD vs. CONT (P = 0.01) at week 8.Two CONT horses received intra-articular anti-inflammatory medication after treatment, which may have altered lameness results.A single dose of clodronate appears to reduce lameness without producing detectable effects on bone turnover markers. Due to the long half-life of a bisphosphonate drug, the effect of multiple doses on bone remodelling and lameness should be investigated. The Summary is available in Portuguese - see Supporting Information." @default.
• W2889059065 created "2018-09-07" @default.
• W2889059065 creator A5016508919 @default.
• W2889059065 creator A5022580796 @default.
• W2889059065 creator A5024601043 @default.
• W2889059065 creator A5035456077 @default.
• W2889059065 creator A5056518945 @default.
• W2889059065 creator A5060840600 @default.
• W2889059065 creator A5091482075 @default.
• W2889059065 date "2018-09-22" @default.
• W2889059065 modified "2023-10-04" @default.
• W2889059065 title "Clodronate improves lameness in horses without changing bone turnover markers" @default.
• W2889059065 cites W1985296670 @default.
• W2889059065 cites W1987328883 @default.
• W2889059065 cites W1994723172 @default.
• W2889059065 cites W2004135633 @default.
• W2889059065 cites W2019076654 @default.
• W2889059065 cites W2029620076 @default.
• W2889059065 cites W2031986053 @default.
• W2889059065 cites W2043122888 @default.
• W2889059065 cites W2045853612 @default.
• W2889059065 cites W2048224727 @default.
• W2889059065 cites W2048500787 @default.
• W2889059065 cites W2056278984 @default.
• W2889059065 cites W2061508823 @default.
• W2889059065 cites W2063340108 @default.
• W2889059065 cites W2066815130 @default.
• W2889059065 cites W2067198393 @default.
• W2889059065 cites W2072668511 @default.
• W2889059065 cites W2079860207 @default.
• W2889059065 cites W2082107301 @default.
• W2889059065 cites W2082407093 @default.
• W2889059065 cites W2090600038 @default.
• W2889059065 cites W2092713460 @default.
• W2889059065 cites W2094554330 @default.
• W2889059065 cites W2098163355 @default.
• W2889059065 cites W2114775653 @default.
• W2889059065 cites W2138336132 @default.
• W2889059065 cites W2164700950 @default.
• W2889059065 cites W2178236910 @default.
• W2889059065 cites W2192512712 @default.
• W2889059065 cites W2272326461 @default.
• W2889059065 cites W2285765643 @default.
• W2889059065 cites W2319566666 @default.
• W2889059065 cites W2325064828 @default.
• W2889059065 cites W2344544926 @default.
• W2889059065 cites W2360896406 @default.
• W2889059065 cites W2470458639 @default.
• W2889059065 cites W2553228575 @default.
• W2889059065 cites W2587922157 @default.
• W2889059065 cites W2617597316 @default.
• W2889059065 cites W2784280828 @default.
• W2889059065 cites W4254128918 @default.
• W2889059065 cites W4255122186 @default.
• W2889059065 cites W4255812842 @default.
• W2889059065 doi "https://doi.org/10.1111/evj.13011" @default.
• W2889059065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30153345" @default.
• W2889059065 hasPublicationYear "2018" @default.
• W2889059065 type Work @default.
• W2889059065 sameAs 2889059065 @default.
• W2889059065 citedByCount "17" @default.
• W2889059065 countsByYear W28890590652019 @default.
• W2889059065 countsByYear W28890590652020 @default.
• W2889059065 countsByYear W28890590652021 @default.
• W2889059065 countsByYear W28890590652022 @default.
• W2889059065 countsByYear W28890590652023 @default.
• W2889059065 crossrefType "journal-article" @default.
• W2889059065 hasAuthorship W2889059065A5016508919 @default.
• W2889059065 hasAuthorship W2889059065A5022580796 @default.
• W2889059065 hasAuthorship W2889059065A5024601043 @default.
• W2889059065 hasAuthorship W2889059065A5035456077 @default.
• W2889059065 hasAuthorship W2889059065A5056518945 @default.
• W2889059065 hasAuthorship W2889059065A5060840600 @default.
• W2889059065 hasAuthorship W2889059065A5091482075 @default.
• W2889059065 hasConcept C126322002 @default.
• W2889059065 hasConcept C131075544 @default.
• W2889059065 hasConcept C141071460 @default.
• W2889059065 hasConcept C151730666 @default.
• W2889059065 hasConcept C160160445 @default.
• W2889059065 hasConcept C170033053 @default.
• W2889059065 hasConcept C181199279 @default.
• W2889059065 hasConcept C2779771469 @default.
• W2889059065 hasConcept C2780762169 @default.
• W2889059065 hasConcept C55493867 @default.
• W2889059065 hasConcept C71924100 @default.
• W2889059065 hasConcept C86803240 @default.
• W2889059065 hasConceptScore W2889059065C126322002 @default.
• W2889059065 hasConceptScore W2889059065C131075544 @default.
• W2889059065 hasConceptScore W2889059065C141071460 @default.
• W2889059065 hasConceptScore W2889059065C151730666 @default.
• W2889059065 hasConceptScore W2889059065C160160445 @default.
• W2889059065 hasConceptScore W2889059065C170033053 @default.
• W2889059065 hasConceptScore W2889059065C181199279 @default.
• W2889059065 hasConceptScore W2889059065C2779771469 @default.
• W2889059065 hasConceptScore W2889059065C2780762169 @default.
• W2889059065 hasConceptScore W2889059065C55493867 @default.
• W2889059065 hasConceptScore W2889059065C71924100 @default.
• W2889059065 hasConceptScore W2889059065C86803240 @default.

• next