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- W2889063462 abstract "Background: Substance abuse is a multifactorial disorder. Scientists have found that an individual’s inherited traits or temperament contributes to the disorder by shaping a personality strongly linked with the risk of substance abuse. DRD2/ANKK1 TaqIA polymorphism is believed to be associated with impulsive behaviors that lead to substance abuse. Methods: We assessed 80 opioid dependent patients using Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) and the Urgency—lack of Perseverance—lack of premeditation—Sensation seeking (UPPS) Impulsive Behavior Scale. We extracted DNA from the subjects’ whole blood and genotyped it for DRD2 allelic variants. Results: Genotype analysis showed that 33.8% of the subjects had TaqIA polymorphism versus 66.3% had normal genotype. The mean value of Urgency subscale of the UPPS in patients with normal genotype is (35.8±9.0) versus (40±8.4) in patients with polymorphism. Conclusions: Patients with TaqIA polymorphism shows statistically significant higher levels of urgency on UPPS than patients with wild genotype." @default.
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- W2889063462 date "2019-03-01" @default.
- W2889063462 modified "2023-09-27" @default.
- W2889063462 title "The Association Between DRD2/ANKK1 TaqIA Polymorphism and Impulsivity in Patients With Opioid Dependence Disorder" @default.
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- W2889063462 doi "https://doi.org/10.1097/adt.0000000000000148" @default.
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