FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889083347> ?p ?o ?g. }

• W2889083347 endingPage "873" @default.
• W2889083347 startingPage "865" @default.
• W2889083347 abstract "Objective/backgroundUnlike most systemic chronic diseases, chronic venous insufficiency (CVI) is ideal to study using endogenous biomarkers. The stimulus causing damage can be turned on and off with gravitational positioning and venous blood samples can be taken locally. Annexin V (apoptosis) and microparticles (cell membrane debris) were used as markers of cell destruction, with matrix metalloproteinases (MMPs) as markers of tissue remodelling. The aim of this proof of concept study was to validate a gravitational model by investigating whether standing induced biochemical stress and whether recovery occurs on lying and after compression.MethodsFourteen patients (C4a–b) and 14 volunteers (C0–1) were tested under three supervised laboratory conditions for 1 h on separate days: (i) stationary standing on a small paper square; (ii) lying with both legs elevated 20°; (iii) compression standing using a 23–32 mmHg below knee stocking. Immediately after each condition, venous blood was withdrawn from the ankle. Commercial enzyme linked immunosorbent assay kits were used for batch analysis of the plasma samples.ResultsMedian (interquartile range [IQR]) values of annexin V (AU/mL) and microparticles (nM) standing were as follows: volunteers 2.9 (2 – 3.4) and 10.2 (8.8 – 13.8), and patients 2.2 (1.3 – 6) and 11.3 (7.7 – 20), respectively. Significant reductions were observed lying: volunteers 2.1 (1.5 – 2.7; p = .019) and 8.5 (7.4 – 9.4; p = .041), patients 1.7 (1.2 – 2.7; p = .004) and 8.5 (7.0 – 11.4; p = .041), respectively. Globally, all median MMP values in the patients reduced with lying and with compression versus standing (p = .004). Individually, significant reductions occurred in MMPs 2 and 13 with compression and MMPs 3, 7, 8, 9, 10, and 12 on lying. Lying was more effective at reducing MMP levels than compression.ConclusionAnnexin V and microparticle concentrations are responsive to elevation and compression after 1 h. In the patients, all the tested MMPs decreased after lying and with compression versus standing. This model provides evidence supporting gravitational protection in the treatment of CVI. Unlike most systemic chronic diseases, chronic venous insufficiency (CVI) is ideal to study using endogenous biomarkers. The stimulus causing damage can be turned on and off with gravitational positioning and venous blood samples can be taken locally. Annexin V (apoptosis) and microparticles (cell membrane debris) were used as markers of cell destruction, with matrix metalloproteinases (MMPs) as markers of tissue remodelling. The aim of this proof of concept study was to validate a gravitational model by investigating whether standing induced biochemical stress and whether recovery occurs on lying and after compression. Fourteen patients (C4a–b) and 14 volunteers (C0–1) were tested under three supervised laboratory conditions for 1 h on separate days: (i) stationary standing on a small paper square; (ii) lying with both legs elevated 20°; (iii) compression standing using a 23–32 mmHg below knee stocking. Immediately after each condition, venous blood was withdrawn from the ankle. Commercial enzyme linked immunosorbent assay kits were used for batch analysis of the plasma samples. Median (interquartile range [IQR]) values of annexin V (AU/mL) and microparticles (nM) standing were as follows: volunteers 2.9 (2 – 3.4) and 10.2 (8.8 – 13.8), and patients 2.2 (1.3 – 6) and 11.3 (7.7 – 20), respectively. Significant reductions were observed lying: volunteers 2.1 (1.5 – 2.7; p = .019) and 8.5 (7.4 – 9.4; p = .041), patients 1.7 (1.2 – 2.7; p = .004) and 8.5 (7.0 – 11.4; p = .041), respectively. Globally, all median MMP values in the patients reduced with lying and with compression versus standing (p = .004). Individually, significant reductions occurred in MMPs 2 and 13 with compression and MMPs 3, 7, 8, 9, 10, and 12 on lying. Lying was more effective at reducing MMP levels than compression. Annexin V and microparticle concentrations are responsive to elevation and compression after 1 h. In the patients, all the tested MMPs decreased after lying and with compression versus standing. This model provides evidence supporting gravitational protection in the treatment of CVI." @default.
• W2889083347 created "2018-09-07" @default.
• W2889083347 creator A5007859032 @default.
• W2889083347 creator A5025139304 @default.
• W2889083347 creator A5045091740 @default.
• W2889083347 creator A5050250185 @default.
• W2889083347 creator A5059218162 @default.
• W2889083347 creator A5064983817 @default.
• W2889083347 creator A5065304304 @default.
• W2889083347 date "2018-12-01" @default.
• W2889083347 modified "2023-10-01" @default.
• W2889083347 title "Validation of a Gravitational Model to Study Local Endogenous Biomarkers in Chronic Venous Insufficiency" @default.
• W2889083347 cites W1687951909 @default.
• W2889083347 cites W1928946763 @default.
• W2889083347 cites W1963595488 @default.
• W2889083347 cites W1992585421 @default.
• W2889083347 cites W2020257026 @default.
• W2889083347 cites W2031540167 @default.
• W2889083347 cites W2031831194 @default.
• W2889083347 cites W2040886298 @default.
• W2889083347 cites W2043379025 @default.
• W2889083347 cites W2050655221 @default.
• W2889083347 cites W2068815982 @default.
• W2889083347 cites W2080060134 @default.
• W2889083347 cites W2107049925 @default.
• W2889083347 cites W2119303645 @default.
• W2889083347 cites W2131601300 @default.
• W2889083347 cites W2145820622 @default.
• W2889083347 cites W2164027309 @default.
• W2889083347 cites W2275737843 @default.
• W2889083347 cites W2280960180 @default.
• W2889083347 cites W2339828323 @default.
• W2889083347 cites W2590514699 @default.
• W2889083347 cites W2600864533 @default.
• W2889083347 cites W2607704951 @default.
• W2889083347 cites W2614027362 @default.
• W2889083347 cites W2617869842 @default.
• W2889083347 cites W2733972101 @default.
• W2889083347 cites W4295715489 @default.
• W2889083347 doi "https://doi.org/10.1016/j.ejvs.2018.08.004" @default.
• W2889083347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30181065" @default.
• W2889083347 hasPublicationYear "2018" @default.
• W2889083347 type Work @default.
• W2889083347 sameAs 2889083347 @default.
• W2889083347 citedByCount "5" @default.
• W2889083347 countsByYear W28890833472020 @default.
• W2889083347 countsByYear W28890833472022 @default.
• W2889083347 crossrefType "journal-article" @default.
• W2889083347 hasAuthorship W2889083347A5007859032 @default.
• W2889083347 hasAuthorship W2889083347A5025139304 @default.
• W2889083347 hasAuthorship W2889083347A5045091740 @default.
• W2889083347 hasAuthorship W2889083347A5050250185 @default.
• W2889083347 hasAuthorship W2889083347A5059218162 @default.
• W2889083347 hasAuthorship W2889083347A5064983817 @default.
• W2889083347 hasAuthorship W2889083347A5065304304 @default.
• W2889083347 hasBestOaLocation W28890833471 @default.
• W2889083347 hasConcept C109523444 @default.
• W2889083347 hasConcept C119060515 @default.
• W2889083347 hasConcept C126322002 @default.
• W2889083347 hasConcept C128709446 @default.
• W2889083347 hasConcept C142724271 @default.
• W2889083347 hasConcept C2776106345 @default.
• W2889083347 hasConcept C43044207 @default.
• W2889083347 hasConcept C71924100 @default.
• W2889083347 hasConcept C74864618 @default.
• W2889083347 hasConcept C88634738 @default.
• W2889083347 hasConceptScore W2889083347C109523444 @default.
• W2889083347 hasConceptScore W2889083347C119060515 @default.
• W2889083347 hasConceptScore W2889083347C126322002 @default.
• W2889083347 hasConceptScore W2889083347C128709446 @default.
• W2889083347 hasConceptScore W2889083347C142724271 @default.
• W2889083347 hasConceptScore W2889083347C2776106345 @default.
• W2889083347 hasConceptScore W2889083347C43044207 @default.
• W2889083347 hasConceptScore W2889083347C71924100 @default.
• W2889083347 hasConceptScore W2889083347C74864618 @default.
• W2889083347 hasConceptScore W2889083347C88634738 @default.
• W2889083347 hasIssue "6" @default.
• W2889083347 hasLocation W28890833471 @default.
• W2889083347 hasLocation W28890833472 @default.
• W2889083347 hasOpenAccess W2889083347 @default.
• W2889083347 hasPrimaryLocation W28890833471 @default.
• W2889083347 hasRelatedWork W2001266125 @default.
• W2889083347 hasRelatedWork W2016169190 @default.
• W2889083347 hasRelatedWork W2048048370 @default.
• W2889083347 hasRelatedWork W2061253854 @default.
• W2889083347 hasRelatedWork W2569122241 @default.
• W2889083347 hasRelatedWork W2971392718 @default.
• W2889083347 hasRelatedWork W3037686638 @default.
• W2889083347 hasRelatedWork W3162511055 @default.
• W2889083347 hasRelatedWork W4251873478 @default.
• W2889083347 hasRelatedWork W4382623110 @default.
• W2889083347 hasVolume "56" @default.
• W2889083347 isParatext "false" @default.
• W2889083347 isRetracted "false" @default.
• W2889083347 magId "2889083347" @default.
• W2889083347 workType "article" @default.