FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889104920> ?p ?o ?g. }

• W2889104920 endingPage "97" @default.
• W2889104920 startingPage "87" @default.
• W2889104920 abstract "An emerging body of evidence consistently suggests that compromised blood-brain barrier integrity may be causally associated with cognitive decline induced by type-2 diabetes. Our previous studies demonstrated that selected anti-inflammatory/anti-oxidative agents can preserve the integrity of blood-brain barrier and prevent neuroinflammation in mouse models of dysfunctional blood-brain barrier. Therefore, we have tested whether the previously proven blood-brain barrier protective agent, probucol, can prevent blood-brain barrier breakdown and cognitive decline in a dietary-induced murine model of diabetic insulin resistance. After 6-month chronic ingestion of a diet high in fat and fructose, the mice became insulin resistant. The high-fat and high-fructose-fed mice showed significant cognitive decline assessed by Morris water maze, concomitant with significant elevations in cortical and hippocampal glial acidic fibrillary protein and Fluoro Jade-C staining, indicating heightened neuroinflammation and neurodegeneration, respectively. The integrity of blood-brain barrier in high-fat and high-fructose-fed mice was substantially compromised, and this showed a significant association with heightened neurodegeneration. Co-provision of probucol with high-fat and high-fructose diet completely prevented the cognitive decline and blood-brain barrier dysfunction. Similarly, metformin was able to restore the cognitive function in high-fat and high-fructose-fed mice, while its blood-brain barrier protective effects were modest. These data suggest that probucol may prevent cognitive decline induced by insulin resistance by preserving the integrity of blood-brain barrier, whereas metformin's neuroprotective effects may be mediated through a separate pathway." @default.
• W2889104920 created "2018-09-07" @default.
• W2889104920 creator A5001579990 @default.
• W2889104920 creator A5018215833 @default.
• W2889104920 creator A5023475995 @default.
• W2889104920 creator A5023520241 @default.
• W2889104920 creator A5026600090 @default.
• W2889104920 creator A5059120275 @default.
• W2889104920 creator A5078918526 @default.
• W2889104920 creator A5079357145 @default.
• W2889104920 date "2018-08-29" @default.
• W2889104920 modified "2023-10-11" @default.
• W2889104920 title "Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet" @default.
• W2889104920 cites W1534989352 @default.
• W2889104920 cites W1567503997 @default.
• W2889104920 cites W1715236271 @default.
• W2889104920 cites W1967239279 @default.
• W2889104920 cites W1967638848 @default.
• W2889104920 cites W1972608963 @default.
• W2889104920 cites W1979100644 @default.
• W2889104920 cites W1983644247 @default.
• W2889104920 cites W1983711535 @default.
• W2889104920 cites W1997307574 @default.
• W2889104920 cites W2001599368 @default.
• W2889104920 cites W2004668790 @default.
• W2889104920 cites W2006938639 @default.
• W2889104920 cites W2018575684 @default.
• W2889104920 cites W2022952278 @default.
• W2889104920 cites W2040687775 @default.
• W2889104920 cites W2045441711 @default.
• W2889104920 cites W2047236508 @default.
• W2889104920 cites W2057042201 @default.
• W2889104920 cites W2059892950 @default.
• W2889104920 cites W2086188681 @default.
• W2889104920 cites W2099448948 @default.
• W2889104920 cites W2110930701 @default.
• W2889104920 cites W2117202783 @default.
• W2889104920 cites W2128550469 @default.
• W2889104920 cites W2141957876 @default.
• W2889104920 cites W2170836786 @default.
• W2889104920 cites W2210499937 @default.
• W2889104920 cites W2268203785 @default.
• W2889104920 cites W2346062209 @default.
• W2889104920 cites W2465184013 @default.
• W2889104920 cites W2588828373 @default.
• W2889104920 cites W2592837816 @default.
• W2889104920 cites W2772162736 @default.
• W2889104920 doi "https://doi.org/10.1177/1479164118795274" @default.
• W2889104920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30156119" @default.
• W2889104920 hasPublicationYear "2018" @default.
• W2889104920 type Work @default.
• W2889104920 sameAs 2889104920 @default.
• W2889104920 citedByCount "37" @default.
• W2889104920 countsByYear W28891049202019 @default.
• W2889104920 countsByYear W28891049202020 @default.
• W2889104920 countsByYear W28891049202021 @default.
• W2889104920 countsByYear W28891049202022 @default.
• W2889104920 countsByYear W28891049202023 @default.
• W2889104920 crossrefType "journal-article" @default.
• W2889104920 hasAuthorship W2889104920A5001579990 @default.
• W2889104920 hasAuthorship W2889104920A5018215833 @default.
• W2889104920 hasAuthorship W2889104920A5023475995 @default.
• W2889104920 hasAuthorship W2889104920A5023520241 @default.
• W2889104920 hasAuthorship W2889104920A5026600090 @default.
• W2889104920 hasAuthorship W2889104920A5059120275 @default.
• W2889104920 hasAuthorship W2889104920A5078918526 @default.
• W2889104920 hasAuthorship W2889104920A5079357145 @default.
• W2889104920 hasBestOaLocation W28891049201 @default.
• W2889104920 hasConcept C126322002 @default.
• W2889104920 hasConcept C134018914 @default.
• W2889104920 hasConcept C25498285 @default.
• W2889104920 hasConcept C2776914184 @default.
• W2889104920 hasConcept C2776925932 @default.
• W2889104920 hasConcept C2777391703 @default.
• W2889104920 hasConcept C2778402981 @default.
• W2889104920 hasConcept C2779134260 @default.
• W2889104920 hasConcept C2779483572 @default.
• W2889104920 hasConcept C2780323712 @default.
• W2889104920 hasConcept C2781161787 @default.
• W2889104920 hasConcept C2984863031 @default.
• W2889104920 hasConcept C44752575 @default.
• W2889104920 hasConcept C529278444 @default.
• W2889104920 hasConcept C555293320 @default.
• W2889104920 hasConcept C71924100 @default.
• W2889104920 hasConcept C87753298 @default.
• W2889104920 hasConceptScore W2889104920C126322002 @default.
• W2889104920 hasConceptScore W2889104920C134018914 @default.
• W2889104920 hasConceptScore W2889104920C25498285 @default.
• W2889104920 hasConceptScore W2889104920C2776914184 @default.
• W2889104920 hasConceptScore W2889104920C2776925932 @default.
• W2889104920 hasConceptScore W2889104920C2777391703 @default.
• W2889104920 hasConceptScore W2889104920C2778402981 @default.
• W2889104920 hasConceptScore W2889104920C2779134260 @default.
• W2889104920 hasConceptScore W2889104920C2779483572 @default.
• W2889104920 hasConceptScore W2889104920C2780323712 @default.
• W2889104920 hasConceptScore W2889104920C2781161787 @default.
• W2889104920 hasConceptScore W2889104920C2984863031 @default.
• W2889104920 hasConceptScore W2889104920C44752575 @default.

• next