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- W2889114489 abstract "Rabies virus is a neurotropic RNA virus that causes encephalitis and still poses an enormous challenge to animal and public health. Efforts to establish reliable therapeutic strategies have been unsuccessful and are hampered by gaps in the understanding of virus pathogenicity. MALT1 is an intracellular protease that mediates the activation of several innate and adaptive immune cells in response to multiple receptors, and therapeutic MALT1 targeting is believed to be a valid approach for autoimmunity and MALT1-addicted cancers. Here, we study the impact of MALT1 deficiency on brain inflammation and disease development in response to infection of mice with the highly virulent CVS-11 rabies virus. We demonstrate that pharmacological or genetic MALT1 inhibition decreases neuroinflammation and extends the survival of CVS-11-infected mice, providing new insights in the biology of MALT1 and rabies virus infection." @default.
- W2889114489 created "2018-09-07" @default.
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- W2889114489 date "2018-11-15" @default.
- W2889114489 modified "2023-10-10" @default.
- W2889114489 title "Inhibition of MALT1 Decreases Neuroinflammation and Pathogenicity of Virulent Rabies Virus in Mice" @default.
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- W2889114489 doi "https://doi.org/10.1128/jvi.00720-18" @default.
- W2889114489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6206481" @default.
- W2889114489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30158289" @default.
- W2889114489 hasPublicationYear "2018" @default.
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