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• W2889127029 startingPage "460" @default.
• W2889127029 abstract "We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical for pore formation. Here, we describe how p7 specifically interacts with host protein CAMLG, an integral ER transmembrane protein involved in intracellular calcium release regulation and signal response generation. Detection of interaction as well as the identification of p7 areas mediating interaction with CAMLG was performed by yeast two-hybrid. p7-CAMLG interaction was further confirmed by confocal microscopy in eukaryotic cells, co-expressing both proteins. Mutant forms of p7 having substituted native residues identified as mediating interaction with CAMLG showed a decreased co-localization compared with the native forms of p7. Furthermore, it is shown that native p7, but not the mutated forms of p7 that fail to interact with CAMLG, efficiently mediates calcium permeability in the ER. Interestingly, viruses harboring some of those mutated forms of p7 have been previously shown to have a significantly decreased virulence in swine." @default.
• W2889127029 created "2018-09-07" @default.
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• W2889127029 date "2018-08-28" @default.
• W2889127029 modified "2023-09-26" @default.
• W2889127029 title "Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum" @default.
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• W2889127029 doi "https://doi.org/10.3390/v10090460" @default.
• W2889127029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165257" @default.
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• W2889127029 hasPublicationYear "2018" @default.
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