Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889156744> ?p ?o ?g. }
- W2889156744 abstract "Pathogens have developed particular strategies to infect and invade their hosts. Amongst these strategies’ figures the modulation of several components of the innate immune system participating in early host defenses, such as the coagulation and complement cascades, as well as the fibrinolytic system. The components of the coagulation cascade and the fibrinolytic system have been proposed to be interfered during host invasion and tissue migration of bacteria, fungi, protozoa, and more recently, helminths. One of the components that has been proposed to facilitate pathogen migration is plasminogen (Plg), a protein found in the host’s plasma, which is activated into plasmin (Plm), a serine protease that degrades fibrin networks and promotes degradation of extracellular matrix (ECM), aiding maintenance of homeostasis. However, pathogens possess Plg-binding proteins that can activate it, therefore taking advantage of the fibrin degradation to facilitate establishment in their hosts. Emergence of Plg-binding proteins appears to have occurred in diverse infectious agents along evolutionary history of host–pathogen relationships. The goal of the present review is to list, summarize, and analyze different examples of Plg-binding proteins used by infectious agents to invade and establish in their hosts. Emphasis was placed on mechanisms used by helminth parasites, particularly taeniid cestodes, where enolase has been identified as a major Plg-binding and activating protein. A new picture is starting to arise about how this glycolytic enzyme could acquire an entirely new role as modulator of the innate immune system in the context of the host–parasite relationship." @default.
- W2889156744 created "2018-09-07" @default.
- W2889156744 creator A5027405585 @default.
- W2889156744 creator A5055287690 @default.
- W2889156744 creator A5088053888 @default.
- W2889156744 creator A5091023604 @default.
- W2889156744 date "2018-10-02" @default.
- W2889156744 modified "2023-10-01" @default.
- W2889156744 title "Plasminogen-binding proteins as an evasion mechanism of the host’s innate immunity in infectious diseases" @default.
- W2889156744 cites W102699897 @default.
- W2889156744 cites W1527548373 @default.
- W2889156744 cites W1529655496 @default.
- W2889156744 cites W1559693804 @default.
- W2889156744 cites W1567591901 @default.
- W2889156744 cites W1627300959 @default.
- W2889156744 cites W1754389422 @default.
- W2889156744 cites W1817172006 @default.
- W2889156744 cites W1842077232 @default.
- W2889156744 cites W1861497351 @default.
- W2889156744 cites W1939603229 @default.
- W2889156744 cites W1968451047 @default.
- W2889156744 cites W1968462304 @default.
- W2889156744 cites W1971378872 @default.
- W2889156744 cites W1972552473 @default.
- W2889156744 cites W1975086865 @default.
- W2889156744 cites W1975820549 @default.
- W2889156744 cites W1979105917 @default.
- W2889156744 cites W1980173932 @default.
- W2889156744 cites W1982204097 @default.
- W2889156744 cites W1986320679 @default.
- W2889156744 cites W1989138487 @default.
- W2889156744 cites W1993745222 @default.
- W2889156744 cites W1996732725 @default.
- W2889156744 cites W1996887447 @default.
- W2889156744 cites W1998258658 @default.
- W2889156744 cites W1999885056 @default.
- W2889156744 cites W2000671695 @default.
- W2889156744 cites W2003275790 @default.
- W2889156744 cites W2004043531 @default.
- W2889156744 cites W2005443987 @default.
- W2889156744 cites W2006404292 @default.
- W2889156744 cites W2013531699 @default.
- W2889156744 cites W2019806909 @default.
- W2889156744 cites W2022602601 @default.
- W2889156744 cites W2024698682 @default.
- W2889156744 cites W2026126834 @default.
- W2889156744 cites W2028944012 @default.
- W2889156744 cites W2030178300 @default.
- W2889156744 cites W2031768516 @default.
- W2889156744 cites W2031817672 @default.
- W2889156744 cites W2033370211 @default.
- W2889156744 cites W2035944542 @default.
- W2889156744 cites W2035986427 @default.
- W2889156744 cites W2036295062 @default.
- W2889156744 cites W2037291623 @default.
- W2889156744 cites W2044967349 @default.
- W2889156744 cites W2045225337 @default.
- W2889156744 cites W2046493944 @default.
- W2889156744 cites W2047011629 @default.
- W2889156744 cites W2049999422 @default.
- W2889156744 cites W2051675224 @default.
- W2889156744 cites W2057251874 @default.
- W2889156744 cites W2058739602 @default.
- W2889156744 cites W2059299669 @default.
- W2889156744 cites W2059622819 @default.
- W2889156744 cites W2061157244 @default.
- W2889156744 cites W2064772203 @default.
- W2889156744 cites W2065309421 @default.
- W2889156744 cites W2067863279 @default.
- W2889156744 cites W2071331125 @default.
- W2889156744 cites W2073734704 @default.
- W2889156744 cites W2074549749 @default.
- W2889156744 cites W2076862889 @default.
- W2889156744 cites W2078129398 @default.
- W2889156744 cites W2087356811 @default.
- W2889156744 cites W2087694422 @default.
- W2889156744 cites W2088914912 @default.
- W2889156744 cites W2089324082 @default.
- W2889156744 cites W2089411617 @default.
- W2889156744 cites W2092832804 @default.
- W2889156744 cites W2094284346 @default.
- W2889156744 cites W2094905667 @default.
- W2889156744 cites W2095462890 @default.
- W2889156744 cites W2097306531 @default.
- W2889156744 cites W2097708776 @default.
- W2889156744 cites W2097802875 @default.
- W2889156744 cites W2100824235 @default.
- W2889156744 cites W2101938124 @default.
- W2889156744 cites W2102134402 @default.
- W2889156744 cites W2103993315 @default.
- W2889156744 cites W2104250120 @default.
- W2889156744 cites W2104422328 @default.
- W2889156744 cites W2105632527 @default.
- W2889156744 cites W2106456576 @default.
- W2889156744 cites W2107695405 @default.
- W2889156744 cites W2108093812 @default.
- W2889156744 cites W2109967445 @default.
- W2889156744 cites W2110895780 @default.
- W2889156744 cites W2113038626 @default.
- W2889156744 cites W2115272551 @default.