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- W2889189968 abstract "Abstract Flotillin-1 (Flot1) is a highly conserved, ubiquitously expressed lipid raft-associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired due to a decrease in myosin II-mediated contractility. Flot1 also accumulates in the uropod of polarized T cells, suggesting an analogous role in T cell migration. Here, we analyzed morphology and migration of naïve and memory WT and Flot1 -/- CD8 + T cells in lymphoid and non-lymphoid tissues with intravital two-photon microscopy, as well as their clonal expansion during antiviral immune responses. Flot1 -/- CD8 + T cells displayed minor alterations in cell shape and motility parameters in vivo but showed comparable homing to lymphoid organs and infiltration into non-lymphoid tissues. Taken together, Flot1 plays a detectable but unexpectedly minor role for CD8 + T cell behavior under physiological conditions." @default.
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- W2889189968 date "2018-08-29" @default.
- W2889189968 modified "2023-09-26" @default.
- W2889189968 title "In vivo function of the lipid raft protein Flotillin 1 during CD8+ T cell-mediated host surveillance" @default.
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- W2889189968 doi "https://doi.org/10.1101/403592" @default.
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