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- W2889201264 endingPage "202" @default.
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- W2889201264 abstract "Many tail-anchored (TA) membrane proteins are targeted to and inserted into the endoplasmic reticulum (ER) by the `guided entry of tail-anchored proteins' (GET) pathway. This post-translational pathway uses transmembrane-domain selective cytosolic chaperones for targeting, and a dedicated membrane protein complex for insertion. The past decade has seen rapid progress towards defining the molecular basis of TA protein biogenesis by the GET pathway. Here we review the mechanisms underlying each step of the pathway, emphasizing recent structural work and highlighting key questions that await future studies." @default.
- W2889201264 created "2018-09-07" @default.
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- W2889201264 date "2018-08-01" @default.
- W2889201264 modified "2023-09-27" @default.
- W2889201264 title "A structural perspective on tail-anchored protein biogenesis by the GET pathway" @default.
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- W2889201264 doi "https://doi.org/10.1016/j.sbi.2018.07.009" @default.
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