Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889204304> ?p ?o ?g. }
- W2889204304 endingPage "1291" @default.
- W2889204304 startingPage "1276" @default.
- W2889204304 abstract "ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Interestingly, ACLY is a strategic enzyme linking both the glycolytic and lipidic metabolism. In tumour cells characterized by an altered energetic metabolism, an increased glucose uptake and an accelerated glycolytic flux lead to an intensified production of mitochondrial citrate. Once transported to the cytosol, citrate is here converted by ACLY to acetyl-CoA, an essential biosynthetic precursor for fatty acid synthesis and mevalonate pathway. ACLY expression and activity proved to be aberrantly expressed in many types of tumours, and its pharmacological or genetic inhibition significantly inhibited cancer cell proliferation and induced apoptosis. Increasing evidences highlight the central role of ACLY, conferring a great therapeutic potential to this enzyme as a key target for the treatment of cancer. ACLY inhibitors, previously developed for metabolic disorders, have recently attracted interest as promising anti-cancer agents. After a brief introduction to the structure and the pathophysiological role of ACLY, this review article provides an overview of the main ACLY inhibitors reported in the literature." @default.
- W2889204304 created "2018-09-07" @default.
- W2889204304 creator A5070335184 @default.
- W2889204304 date "2018-09-01" @default.
- W2889204304 modified "2023-10-07" @default.
- W2889204304 title "ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism" @default.
- W2889204304 cites W111603817 @default.
- W2889204304 cites W136372353 @default.
- W2889204304 cites W1488831417 @default.
- W2889204304 cites W1511256877 @default.
- W2889204304 cites W1525868105 @default.
- W2889204304 cites W1530264777 @default.
- W2889204304 cites W1530265295 @default.
- W2889204304 cites W1537788998 @default.
- W2889204304 cites W1569698669 @default.
- W2889204304 cites W1595100801 @default.
- W2889204304 cites W1655460539 @default.
- W2889204304 cites W1857663964 @default.
- W2889204304 cites W189473508 @default.
- W2889204304 cites W1968746232 @default.
- W2889204304 cites W1971839306 @default.
- W2889204304 cites W1973054593 @default.
- W2889204304 cites W1973137063 @default.
- W2889204304 cites W1982033430 @default.
- W2889204304 cites W1983616310 @default.
- W2889204304 cites W1986186950 @default.
- W2889204304 cites W1986797467 @default.
- W2889204304 cites W1988312383 @default.
- W2889204304 cites W1989438670 @default.
- W2889204304 cites W1989834355 @default.
- W2889204304 cites W1992490718 @default.
- W2889204304 cites W1998868825 @default.
- W2889204304 cites W2003829494 @default.
- W2889204304 cites W2003863419 @default.
- W2889204304 cites W2008550831 @default.
- W2889204304 cites W2020110583 @default.
- W2889204304 cites W2021740841 @default.
- W2889204304 cites W2026784277 @default.
- W2889204304 cites W2032443341 @default.
- W2889204304 cites W2032768487 @default.
- W2889204304 cites W2037502917 @default.
- W2889204304 cites W2044550149 @default.
- W2889204304 cites W2045926990 @default.
- W2889204304 cites W2046838202 @default.
- W2889204304 cites W2046976278 @default.
- W2889204304 cites W2047738369 @default.
- W2889204304 cites W2048548143 @default.
- W2889204304 cites W2048935510 @default.
- W2889204304 cites W2052584789 @default.
- W2889204304 cites W2056780561 @default.
- W2889204304 cites W2059300250 @default.
- W2889204304 cites W2060408030 @default.
- W2889204304 cites W2062439849 @default.
- W2889204304 cites W2063343639 @default.
- W2889204304 cites W2064318855 @default.
- W2889204304 cites W2065191931 @default.
- W2889204304 cites W2069386055 @default.
- W2889204304 cites W2069667295 @default.
- W2889204304 cites W2070895117 @default.
- W2889204304 cites W2072451938 @default.
- W2889204304 cites W2072524853 @default.
- W2889204304 cites W2072981894 @default.
- W2889204304 cites W2075497602 @default.
- W2889204304 cites W2081019639 @default.
- W2889204304 cites W2085536106 @default.
- W2889204304 cites W2086222405 @default.
- W2889204304 cites W2086546138 @default.
- W2889204304 cites W2090038705 @default.
- W2889204304 cites W2099263548 @default.
- W2889204304 cites W2103292784 @default.
- W2889204304 cites W2116501341 @default.
- W2889204304 cites W2125785670 @default.
- W2889204304 cites W2127624416 @default.
- W2889204304 cites W2129578108 @default.
- W2889204304 cites W2134285011 @default.
- W2889204304 cites W2136765222 @default.
- W2889204304 cites W2137083729 @default.
- W2889204304 cites W2137610276 @default.
- W2889204304 cites W2144575277 @default.
- W2889204304 cites W2145686552 @default.
- W2889204304 cites W2146650180 @default.
- W2889204304 cites W2151216008 @default.
- W2889204304 cites W2158062662 @default.
- W2889204304 cites W2159787500 @default.
- W2889204304 cites W2160518775 @default.
- W2889204304 cites W2165268351 @default.
- W2889204304 cites W2167753201 @default.
- W2889204304 cites W2168921982 @default.
- W2889204304 cites W2170362450 @default.
- W2889204304 cites W2170640967 @default.
- W2889204304 cites W2280924661 @default.
- W2889204304 cites W2291752147 @default.
- W2889204304 cites W2328278900 @default.
- W2889204304 cites W2336491195 @default.
- W2889204304 cites W2397446494 @default.
- W2889204304 cites W2434847197 @default.
- W2889204304 cites W2521647868 @default.
- W2889204304 cites W2522837182 @default.