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- W2889255252 abstract "Abstract The paper presents novel Lomefloxacin delivery systems based on heteroatom modified MCM-41-type silica materials. The modification of MCM-41 mesoporous silica with Mg, Fe, Ce or Zn was performed by ion-exchange approach and the resulted materials exhibited an ordered pore framework, high specific surface area (in the range of 510–813 m2/g), total pore volume (from 0.47 to 0.96 cm3/g), and uniform distribution of heteroatoms, which allow their use as carriers in drug delivery systems. The heteroatom modification of MCM-41 silica led either to the formation of amorphous metal oxide on the inner pore surface in the case of Mg and Zn, or materials with a crystalline oxide phase (CeO2 or Fe2O3) on the silica surface. The drug release profiles from heteroatom modified MCM-41 carriers were determined in simulated body fluid pH 7.4 and all Lomefloxacin-loaded samples exhibited a slower release kinetics than the antibiotic dissolution, the lowest delivery rate being obtained for Mg-modified MCM-41 material. All the prepared antibiotic delivery systems presented good bactericide activity against E. coli strain." @default.
- W2889255252 created "2018-09-07" @default.
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- W2889255252 date "2019-02-01" @default.
- W2889255252 modified "2023-09-26" @default.
- W2889255252 title "Heteroatom modified MCM-41-silica carriers for Lomefloxacin delivery systems" @default.
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- W2889255252 doi "https://doi.org/10.1016/j.micromeso.2018.08.031" @default.
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