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• W2889272710 endingPage "19" @default.
• W2889272710 startingPage "1" @default.
• W2889272710 abstract "Objective. Systemic sclerosis (SSc) is a systemic connective tissue disease of unknown etiology. Aberrant gene expression and epigenetic modifications in circulating immune cells have been implicated in the pathogenesis of SSc. This study is to delineate the interaction network between gene transcription and DNA methylation in PBMC of SSc patients and to identify methylation-regulated genes which are involved in the pathogenesis of SSc. Methods. Genome-wide mRNA transcription and global DNA methylation analysis were performed on PBMC from 18 SSc patients and 19 matched normal controls (NC) using Illumina BeadChips. Differentially expressed genes (DEGs) and differentially methylated positions (DMPs) were integrative analyzed to identify methylation-regulated genes and associated molecular pathways . Results. Transcriptome analysis distinguished 453 DEGs (269 up- and 184 downregulated) in SSc from NC. Global DNA methylation analysis identified 925 DMPs located on 618 genes. Integration of the two lists revealed only 20 DEGs which harbor inversely correlated DMPs, including 12 upregulated (ELANE, CTSG, LTBR, C3AR1, CSTA, SPI1, ODF3B, SAMD4A, PLAUR, NFE2, ZYX, and CTSZ) and eight downregulated genes (RUNX3, PRF1, PRKCH, PAG1, RASSF5, FYN, CXCR6, and F2R). These potential methylation-regulated DEGs (MeDEGs) are enriched in the pathways related to immune cell migration, proliferation, activation, and inflammation activities. Using a machine learning algorism, we identified six out of the 20 MeDEGs, including F2R, CXCR6, FYN, LTBR, CTSG, and ELANE, which distinguished SSc from NC with 100% accuracy. Four genes (F2R, FYN, PAG1, and PRKCH) differentially expressed in SSc with interstitial lung disease (ILD) compared to SSc without ILD. Conclusion. The identified MeDEGs may represent novel candidate factors which lead to the abnormal activation of immune regulatory pathways in the pathogenesis of SSc. They may also be used as diagnostic biomarkers for SSc and clinical complications." @default.
• W2889272710 created "2018-09-07" @default.
• W2889272710 creator A5017351585 @default.
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• W2889272710 creator A5047497810 @default.
• W2889272710 creator A5047943765 @default.
• W2889272710 creator A5057842190 @default.
• W2889272710 creator A5091484412 @default.
• W2889272710 date "2018-09-02" @default.
• W2889272710 modified "2023-10-15" @default.
• W2889272710 title "Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis" @default.
• W2889272710 cites W1483118820 @default.
• W2889272710 cites W1487243251 @default.
• W2889272710 cites W1518950845 @default.
• W2889272710 cites W1590687564 @default.
• W2889272710 cites W1663976198 @default.
• W2889272710 cites W1953734276 @default.
• W2889272710 cites W1964895626 @default.
• W2889272710 cites W1964940342 @default.
• W2889272710 cites W1966579788 @default.
• W2889272710 cites W1966597513 @default.
• W2889272710 cites W1967064280 @default.
• W2889272710 cites W1976574577 @default.
• W2889272710 cites W1976787939 @default.
• W2889272710 cites W1980494884 @default.
• W2889272710 cites W1987728581 @default.
• W2889272710 cites W1988593940 @default.
• W2889272710 cites W1989059764 @default.
• W2889272710 cites W1991560558 @default.
• W2889272710 cites W1994419931 @default.
• W2889272710 cites W1997890656 @default.
• W2889272710 cites W1998727509 @default.
• W2889272710 cites W2004221672 @default.
• W2889272710 cites W2005041300 @default.
• W2889272710 cites W2005075935 @default.
• W2889272710 cites W2010043145 @default.
• W2889272710 cites W2011045499 @default.
• W2889272710 cites W2013359460 @default.
• W2889272710 cites W2014852291 @default.
• W2889272710 cites W2015155035 @default.
• W2889272710 cites W2017357341 @default.
• W2889272710 cites W2017907569 @default.
• W2889272710 cites W2025918616 @default.
• W2889272710 cites W2028781819 @default.
• W2889272710 cites W2029330507 @default.
• W2889272710 cites W2033605121 @default.
• W2889272710 cites W2034338127 @default.
• W2889272710 cites W2034902085 @default.
• W2889272710 cites W2042052097 @default.
• W2889272710 cites W2042096696 @default.
• W2889272710 cites W2051701435 @default.
• W2889272710 cites W2060880575 @default.
• W2889272710 cites W2061481168 @default.
• W2889272710 cites W2067365713 @default.
• W2889272710 cites W2072930625 @default.
• W2889272710 cites W2080508036 @default.
• W2889272710 cites W2089157650 @default.
• W2889272710 cites W2095401663 @default.
• W2889272710 cites W2099447582 @default.
• W2889272710 cites W2104347367 @default.
• W2889272710 cites W2106143687 @default.
• W2889272710 cites W2106608030 @default.
• W2889272710 cites W2108728387 @default.
• W2889272710 cites W2119143823 @default.
• W2889272710 cites W2127925738 @default.
• W2889272710 cites W2136037247 @default.
• W2889272710 cites W2136895197 @default.
• W2889272710 cites W2137558988 @default.
• W2889272710 cites W2140004993 @default.
• W2889272710 cites W2141224543 @default.
• W2889272710 cites W2142980451 @default.
• W2889272710 cites W2144251393 @default.
• W2889272710 cites W2147201883 @default.
• W2889272710 cites W2155363240 @default.
• W2889272710 cites W2158217645 @default.
• W2889272710 cites W2159161058 @default.
• W2889272710 cites W2201568507 @default.
• W2889272710 cites W2202022139 @default.
• W2889272710 cites W2219957567 @default.
• W2889272710 cites W2253235589 @default.
• W2889272710 cites W2289832887 @default.
• W2889272710 cites W2302291481 @default.
• W2889272710 cites W2318466455 @default.
• W2889272710 cites W2327388943 @default.
• W2889272710 cites W2335317075 @default.
• W2889272710 cites W2335982655 @default.
• W2889272710 cites W2399648151 @default.
• W2889272710 cites W2402757143 @default.
• W2889272710 cites W2406300505 @default.
• W2889272710 cites W2473105536 @default.
• W2889272710 cites W2481786066 @default.
• W2889272710 cites W2506757525 @default.
• W2889272710 cites W2515007219 @default.
• W2889272710 cites W2539647748 @default.
• W2889272710 cites W2546442416 @default.
• W2889272710 cites W2552070532 @default.

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