FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889276413> ?p ?o ?g. }

• W2889276413 endingPage "245" @default.
• W2889276413 startingPage "237" @default.
• W2889276413 abstract "Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro-survival and anti-apoptotic roles through molecule phosphorylated extracellular signal-regulated kinase1/2 (p-ERK1/2) in cardiomyocytes. However, it is still unclear if silencing of C3G may increase cell survival inhibition and apoptosis in cardiomyocytes, and whether C3G silence induced injuries are reduced by the overexpression of C3G through regulation of p-ERK1/2 and pro-apoptotic molecule Bax. In this study, the rat-derived H9C2 cardiomyocytes were infected with C3G small hairpin RNA interference recombinant lentiviruses, which silenced the endogenous C3G expression in the cardiomyocytes. Then, contrary experiments were conducted using C3G overexpression. The cell proliferation and apoptosis were analyzed in the cardiomyocytes which were treated with or without hypoxia/reoxygenation (H/R). Silencing of C3G leaded to significant increase in cell survival inhibition and apoptosis, combined with aggravated the injuries induced by H/R. Overexpression of C3G reduced the injuries induced by the silencing of C3G in the cardiomyocytes via regulation of p-ERK1/2 and Bax. In conclusion, our results provide new experimental evidence that silencing of C3G can increase cell survival inhibition and apoptosis in cardiomyocytes via regulation of p-ERK1/2 and Bax." @default.
• W2889276413 created "2018-09-07" @default.
• W2889276413 creator A5021628594 @default.
• W2889276413 creator A5053917493 @default.
• W2889276413 creator A5064538142 @default.
• W2889276413 creator A5071798264 @default.
• W2889276413 creator A5074942308 @default.
• W2889276413 creator A5082715194 @default.
• W2889276413 creator A5086698395 @default.
• W2889276413 date "2018-09-27" @default.
• W2889276413 modified "2023-10-05" @default.
• W2889276413 title "Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p‐ERK1/2 and Bax" @default.
• W2889276413 cites W1510768543 @default.
• W2889276413 cites W1971949657 @default.
• W2889276413 cites W1973030441 @default.
• W2889276413 cites W1974850525 @default.
• W2889276413 cites W1977731744 @default.
• W2889276413 cites W1989695840 @default.
• W2889276413 cites W2000653676 @default.
• W2889276413 cites W2013008816 @default.
• W2889276413 cites W2034685620 @default.
• W2889276413 cites W2052162125 @default.
• W2889276413 cites W2053062892 @default.
• W2889276413 cites W2057516068 @default.
• W2889276413 cites W2059348822 @default.
• W2889276413 cites W2071304271 @default.
• W2889276413 cites W2104190934 @default.
• W2889276413 cites W2104633662 @default.
• W2889276413 cites W2117914440 @default.
• W2889276413 cites W2127382187 @default.
• W2889276413 cites W2134404947 @default.
• W2889276413 cites W2140597616 @default.
• W2889276413 cites W2146500145 @default.
• W2889276413 cites W2151866543 @default.
• W2889276413 cites W2152333861 @default.
• W2889276413 cites W2153570571 @default.
• W2889276413 cites W2154059094 @default.
• W2889276413 cites W2168929628 @default.
• W2889276413 cites W2329305567 @default.
• W2889276413 cites W2765784023 @default.
• W2889276413 doi "https://doi.org/10.1111/1440-1681.13027" @default.
• W2889276413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30152875" @default.
• W2889276413 hasPublicationYear "2018" @default.
• W2889276413 type Work @default.
• W2889276413 sameAs 2889276413 @default.
• W2889276413 citedByCount "2" @default.
• W2889276413 countsByYear W28892764132020 @default.
• W2889276413 crossrefType "journal-article" @default.
• W2889276413 hasAuthorship W2889276413A5021628594 @default.
• W2889276413 hasAuthorship W2889276413A5053917493 @default.
• W2889276413 hasAuthorship W2889276413A5064538142 @default.
• W2889276413 hasAuthorship W2889276413A5071798264 @default.
• W2889276413 hasAuthorship W2889276413A5074942308 @default.
• W2889276413 hasAuthorship W2889276413A5082715194 @default.
• W2889276413 hasAuthorship W2889276413A5086698395 @default.
• W2889276413 hasBestOaLocation W28892764132 @default.
• W2889276413 hasConcept C104317684 @default.
• W2889276413 hasConcept C119056186 @default.
• W2889276413 hasConcept C153911025 @default.
• W2889276413 hasConcept C166703698 @default.
• W2889276413 hasConcept C173396325 @default.
• W2889276413 hasConcept C190232843 @default.
• W2889276413 hasConcept C190283241 @default.
• W2889276413 hasConcept C31573885 @default.
• W2889276413 hasConcept C55493867 @default.
• W2889276413 hasConcept C67705224 @default.
• W2889276413 hasConcept C86803240 @default.
• W2889276413 hasConcept C95444343 @default.
• W2889276413 hasConceptScore W2889276413C104317684 @default.
• W2889276413 hasConceptScore W2889276413C119056186 @default.
• W2889276413 hasConceptScore W2889276413C153911025 @default.
• W2889276413 hasConceptScore W2889276413C166703698 @default.
• W2889276413 hasConceptScore W2889276413C173396325 @default.
• W2889276413 hasConceptScore W2889276413C190232843 @default.
• W2889276413 hasConceptScore W2889276413C190283241 @default.
• W2889276413 hasConceptScore W2889276413C31573885 @default.
• W2889276413 hasConceptScore W2889276413C55493867 @default.
• W2889276413 hasConceptScore W2889276413C67705224 @default.
• W2889276413 hasConceptScore W2889276413C86803240 @default.
• W2889276413 hasConceptScore W2889276413C95444343 @default.
• W2889276413 hasIssue "3" @default.
• W2889276413 hasLocation W28892764131 @default.
• W2889276413 hasLocation W28892764132 @default.
• W2889276413 hasLocation W28892764133 @default.
• W2889276413 hasOpenAccess W2889276413 @default.
• W2889276413 hasPrimaryLocation W28892764131 @default.
• W2889276413 hasRelatedWork W1977799254 @default.
• W2889276413 hasRelatedWork W1985468162 @default.
• W2889276413 hasRelatedWork W2006350083 @default.
• W2889276413 hasRelatedWork W2030652381 @default.
• W2889276413 hasRelatedWork W2094767084 @default.
• W2889276413 hasRelatedWork W2373539659 @default.
• W2889276413 hasRelatedWork W2387605231 @default.
• W2889276413 hasRelatedWork W2401722534 @default.
• W2889276413 hasRelatedWork W2892436319 @default.
• W2889276413 hasRelatedWork W3146657483 @default.
• W2889276413 hasVolume "46" @default.
• W2889276413 isParatext "false" @default.

• next