FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889281288> ?p ?o ?g. }

• W2889281288 endingPage "5847" @default.
• W2889281288 startingPage "5833" @default.
• W2889281288 abstract "Abstract Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer. These mutations include p53-inactivating mutations as well as oncogenic gain-of-function (GOF) mutations that endow p53 with capabilities to promote tumor progression. A primary challenge in cancer therapy is targeting stemness features and cancer stem cells (CSC) that account for tumor initiation, metastasis, and cancer relapse. Here we show that in vitro cultivation of tumors derived from mutant p53 murine bone marrow mesenchymal stem cells (MSC) gives rise to aggressive tumor lines (TL). These MSC-TLs exhibited CSC features as displayed by their augmented oncogenicity and high expression of CSC markers. Comparative analyses between MSC-TL with their parental mutant p53 MSC allowed for identification of the molecular events underlying their tumorigenic properties, including an embryonic stem cell (ESC) gene signature specifically expressed in MSC-TLs. Knockout of mutant p53 led to a reduction in tumor development and tumorigenic cell frequency, which was accompanied by reduced expression of CSC markers and the ESC MSC-TL signature. In human cancer, MSC-TL ESC signature–derived genes correlated with poor patient survival and were highly expressed in human tumors harboring p53 hotspot mutations. These data indicate that the ESC gene signature–derived genes may serve as new stemness-based prognostic biomarkers as well as novel cancer therapeutic targets. Significance: Mesenchymal cancer stem cell-like cell lines express a mutant p53-dependent embryonic stem cell gene signature, which can serve as a potential prognostic biomarker and therapeutic target in cancer. Cancer Res; 78(20); 5833–47. ©2018 AACR." @default.
• W2889281288 created "2018-09-07" @default.
• W2889281288 creator A5002970839 @default.
• W2889281288 creator A5002972268 @default.
• W2889281288 creator A5010440261 @default.
• W2889281288 creator A5010478613 @default.
• W2889281288 creator A5014463135 @default.
• W2889281288 creator A5032492224 @default.
• W2889281288 creator A5048004012 @default.
• W2889281288 creator A5068008988 @default.
• W2889281288 creator A5077537699 @default.
• W2889281288 date "2018-10-15" @default.
• W2889281288 modified "2023-10-18" @default.
• W2889281288 title "A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells" @default.
• W2889281288 cites W1964025406 @default.
• W2889281288 cites W1965428318 @default.
• W2889281288 cites W1968075505 @default.
• W2889281288 cites W1973748124 @default.
• W2889281288 cites W1975148552 @default.
• W2889281288 cites W1992817971 @default.
• W2889281288 cites W1995068068 @default.
• W2889281288 cites W1998196049 @default.
• W2889281288 cites W1999356404 @default.
• W2889281288 cites W2002819368 @default.
• W2889281288 cites W2002835135 @default.
• W2889281288 cites W2004935845 @default.
• W2889281288 cites W2008299229 @default.
• W2889281288 cites W2011181841 @default.
• W2889281288 cites W2014691022 @default.
• W2889281288 cites W2018330645 @default.
• W2889281288 cites W2020541351 @default.
• W2889281288 cites W2029803778 @default.
• W2889281288 cites W2033887346 @default.
• W2889281288 cites W2034882416 @default.
• W2889281288 cites W2043634672 @default.
• W2889281288 cites W2072423468 @default.
• W2889281288 cites W2073759231 @default.
• W2889281288 cites W2080392221 @default.
• W2889281288 cites W2086277161 @default.
• W2889281288 cites W2089477889 @default.
• W2889281288 cites W2106316818 @default.
• W2889281288 cites W2114254430 @default.
• W2889281288 cites W2115687722 @default.
• W2889281288 cites W2130552015 @default.
• W2889281288 cites W2132790996 @default.
• W2889281288 cites W2141356279 @default.
• W2889281288 cites W2150479858 @default.
• W2889281288 cites W2159792406 @default.
• W2889281288 cites W2162143298 @default.
• W2889281288 cites W2163853500 @default.
• W2889281288 cites W2167679665 @default.
• W2889281288 cites W2175728132 @default.
• W2889281288 cites W2213124311 @default.
• W2889281288 cites W2283488635 @default.
• W2889281288 cites W2593074826 @default.
• W2889281288 cites W2783037283 @default.
• W2889281288 doi "https://doi.org/10.1158/0008-5472.can-18-0805" @default.
• W2889281288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30154152" @default.
• W2889281288 hasPublicationYear "2018" @default.
• W2889281288 type Work @default.
• W2889281288 sameAs 2889281288 @default.
• W2889281288 citedByCount "19" @default.
• W2889281288 countsByYear W28892812882018 @default.
• W2889281288 countsByYear W28892812882019 @default.
• W2889281288 countsByYear W28892812882020 @default.
• W2889281288 countsByYear W28892812882021 @default.
• W2889281288 countsByYear W28892812882022 @default.
• W2889281288 crossrefType "journal-article" @default.
• W2889281288 hasAuthorship W2889281288A5002970839 @default.
• W2889281288 hasAuthorship W2889281288A5002972268 @default.
• W2889281288 hasAuthorship W2889281288A5010440261 @default.
• W2889281288 hasAuthorship W2889281288A5010478613 @default.
• W2889281288 hasAuthorship W2889281288A5014463135 @default.
• W2889281288 hasAuthorship W2889281288A5032492224 @default.
• W2889281288 hasAuthorship W2889281288A5048004012 @default.
• W2889281288 hasAuthorship W2889281288A5068008988 @default.
• W2889281288 hasAuthorship W2889281288A5077537699 @default.
• W2889281288 hasBestOaLocation W28892812881 @default.
• W2889281288 hasConcept C104317684 @default.
• W2889281288 hasConcept C121608353 @default.
• W2889281288 hasConcept C145103041 @default.
• W2889281288 hasConcept C150194340 @default.
• W2889281288 hasConcept C198826908 @default.
• W2889281288 hasConcept C2779013556 @default.
• W2889281288 hasConcept C2779733811 @default.
• W2889281288 hasConcept C28328180 @default.
• W2889281288 hasConcept C502942594 @default.
• W2889281288 hasConcept C54355233 @default.
• W2889281288 hasConcept C55427017 @default.
• W2889281288 hasConcept C555283112 @default.
• W2889281288 hasConcept C86803240 @default.
• W2889281288 hasConcept C96232424 @default.
• W2889281288 hasConceptScore W2889281288C104317684 @default.
• W2889281288 hasConceptScore W2889281288C121608353 @default.
• W2889281288 hasConceptScore W2889281288C145103041 @default.
• W2889281288 hasConceptScore W2889281288C150194340 @default.
• W2889281288 hasConceptScore W2889281288C198826908 @default.
• W2889281288 hasConceptScore W2889281288C2779013556 @default.

• next