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- W2889300460 abstract "Abstract Liver cancer, also known as primary liver cancer, is cancer that starts in the liver. JNU-144, a new meroterpenoid purified from Lithospermum erythrorhizon , has exhibited promising anticancer activity; however, the molecular mechanisms of action of JNU-144 on malignant cells remain unclear. Our studies revealed that JNU-144 suppressed cell viability and proliferation in hepatoma cells by downregulating mTOR activation. Meanwhile, JNU-144 activated the intrinsic apoptosis pathway and subsequently triggered apoptotic cell death in SMMC-7721 cells. We also found that JNU-144 inhibited the epithelial–mesenchymal transition in both SMMC-7721 and HepG2 cells through reprogramming of epithelial–mesenchymal transition (EMT)-related gene expression or regulating protein instability. These findings indicate that JNU-144 exerts potent anticancer activity in hepatoma cells and may be developed as a potential therapeutic drug." @default.
- W2889300460 created "2018-09-07" @default.
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- W2889300460 date "2018-09-03" @default.
- W2889300460 modified "2023-09-23" @default.
- W2889300460 title "A new meroterpenoid functions as an anti-tumor agent in hepatoma cells by downregulating mTOR activation and inhibiting EMT" @default.
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- W2889300460 doi "https://doi.org/10.1038/s41598-018-31409-2" @default.
- W2889300460 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6120861" @default.
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