FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889307312> ?p ?o ?g. }

• W2889307312 endingPage "1189" @default.
• W2889307312 startingPage "1180" @default.
• W2889307312 abstract "Objective Human gut microbiome studies are mainly bacteria- and archaea-oriented, overlooking the presence of single-cell eukaryotes such as Blastocystis, an enteric stramenopiles with worldwide distribution. Here, we surveyed the prevalence and subtype variation of Blastocystis in faecal samples collected as part of the Flemish Gut Flora Project (FGFP), a Western population cohort. We assessed potential links between Blastocystis subtypes and identified microbiota–host covariates and quantified microbiota differentiation relative to subtype abundances. Design We profiled stool samples from 616 healthy individuals from the FGFP cohort as well as 107 patients with IBD using amplicon sequencing targeting the V4 variable region of the 16S rRNA and 18S rRNA genes. We evaluated associations of Blastocystis , and their subtypes, with host parameters, diversity and composition of bacterial and archaeal communities. Results Blastocystis prevalence in the non-clinical population cohort was 30% compared with 4% among Flemish patients with IBD. Within the FGFP cohort, out of 69 previously identified gut microbiota covariates, only age was associated with Blastocystis subtype carrier status. In contrast, a strong association between microbiota community composition and Blastocystis subtypes was observed, with effect sizes larger than that of host covariates. Microbial richness and diversity were linked to both Blastocystis prevalence and subtype variation. All Blastocystis subtypes detected in this cohort were found to be less prevalent in Bacteroides enterotyped samples. Interestingly, Blastocystis subtypes 3 and 4 were inversely correlated with Akkermansia , suggesting differential associations of subtypes with host health. Conclusions These results emphasise the role of Blastocystis as a common constituent of the healthy gut microbiota. We show its prevalence is reduced in patients with active IBD and demonstrate that subtype characterisation is essential for assessing the relationship between Blastocystis , microbiota profile and host health. These findings have direct clinical applications, especially in donor selection for faecal transplantation." @default.
• W2889307312 created "2018-09-07" @default.
• W2889307312 creator A5003198691 @default.
• W2889307312 creator A5009391192 @default.
• W2889307312 creator A5019474609 @default.
• W2889307312 creator A5020057596 @default.
• W2889307312 creator A5022452005 @default.
• W2889307312 creator A5023078719 @default.
• W2889307312 creator A5029032681 @default.
• W2889307312 creator A5038895407 @default.
• W2889307312 creator A5040564456 @default.
• W2889307312 creator A5042241049 @default.
• W2889307312 creator A5043828779 @default.
• W2889307312 creator A5068548156 @default.
• W2889307312 creator A5071053092 @default.
• W2889307312 creator A5074880809 @default.
• W2889307312 creator A5091623976 @default.
• W2889307312 date "2018-08-31" @default.
• W2889307312 modified "2023-10-11" @default.
• W2889307312 title "Population-level analysis of <i>Blastocystis</i> subtype prevalence and variation in the human gut microbiota" @default.
• W2889307312 cites W1656494246 @default.
• W2889307312 cites W1857457305 @default.
• W2889307312 cites W1982367660 @default.
• W2889307312 cites W2004549986 @default.
• W2889307312 cites W2031643071 @default.
• W2889307312 cites W2051462701 @default.
• W2889307312 cites W2056279562 @default.
• W2889307312 cites W2063367588 @default.
• W2889307312 cites W2071757128 @default.
• W2889307312 cites W2088833470 @default.
• W2889307312 cites W2092252755 @default.
• W2889307312 cites W2095885321 @default.
• W2889307312 cites W2105329815 @default.
• W2889307312 cites W2107903949 @default.
• W2889307312 cites W2110065044 @default.
• W2889307312 cites W2124141867 @default.
• W2889307312 cites W2125784987 @default.
• W2889307312 cites W2125826054 @default.
• W2889307312 cites W2134568639 @default.
• W2889307312 cites W2136417551 @default.
• W2889307312 cites W2141416829 @default.
• W2889307312 cites W2146580089 @default.
• W2889307312 cites W2147790901 @default.
• W2889307312 cites W2152885278 @default.
• W2889307312 cites W2162984639 @default.
• W2889307312 cites W2162992036 @default.
• W2889307312 cites W2163632018 @default.
• W2889307312 cites W2178459747 @default.
• W2889307312 cites W2206854629 @default.
• W2889307312 cites W2311203695 @default.
• W2889307312 cites W2330978860 @default.
• W2889307312 cites W2342540743 @default.
• W2889307312 cites W2345609078 @default.
• W2889307312 cites W2401992505 @default.
• W2889307312 cites W2414354977 @default.
• W2889307312 cites W2431864197 @default.
• W2889307312 cites W2434635261 @default.
• W2889307312 cites W2461051021 @default.
• W2889307312 cites W2462759270 @default.
• W2889307312 cites W2550554388 @default.
• W2889307312 cites W2559267012 @default.
• W2889307312 cites W2571820890 @default.
• W2889307312 cites W2576253980 @default.
• W2889307312 cites W2588997555 @default.
• W2889307312 cites W2591036460 @default.
• W2889307312 cites W2592003794 @default.
• W2889307312 cites W2593635259 @default.
• W2889307312 cites W2608965099 @default.
• W2889307312 cites W2610214149 @default.
• W2889307312 cites W2623963207 @default.
• W2889307312 cites W2728274556 @default.
• W2889307312 cites W2747743284 @default.
• W2889307312 cites W2759859016 @default.
• W2889307312 cites W2770269406 @default.
• W2889307312 cites W2794407684 @default.
• W2889307312 cites W4245901258 @default.
• W2889307312 doi "https://doi.org/10.1136/gutjnl-2018-316106" @default.
• W2889307312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6582744" @default.
• W2889307312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30171064" @default.
• W2889307312 hasPublicationYear "2018" @default.
• W2889307312 type Work @default.
• W2889307312 sameAs 2889307312 @default.
• W2889307312 citedByCount "126" @default.
• W2889307312 countsByYear W28893073122017 @default.
• W2889307312 countsByYear W28893073122019 @default.
• W2889307312 countsByYear W28893073122020 @default.
• W2889307312 countsByYear W28893073122021 @default.
• W2889307312 countsByYear W28893073122022 @default.
• W2889307312 countsByYear W28893073122023 @default.
• W2889307312 crossrefType "journal-article" @default.
• W2889307312 hasAuthorship W2889307312A5003198691 @default.
• W2889307312 hasAuthorship W2889307312A5009391192 @default.
• W2889307312 hasAuthorship W2889307312A5019474609 @default.
• W2889307312 hasAuthorship W2889307312A5020057596 @default.
• W2889307312 hasAuthorship W2889307312A5022452005 @default.
• W2889307312 hasAuthorship W2889307312A5023078719 @default.
• W2889307312 hasAuthorship W2889307312A5029032681 @default.
• W2889307312 hasAuthorship W2889307312A5038895407 @default.

• next