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• W2889334837 abstract "Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric risk and underlying pathophysiology that can be targeted by new treatments. Much convergent evidence from the human literature associates inflammation during pregnancy with later neuropsychiatric disorders in offspring. Preclinical models of prenatal inflammation have been developed to examine the causal maternal physiological and offspring neural mechanisms underlying these findings. Here we review the strengths and limitations of preclinical models used for these purposes and describe selected studies that have shown maternal immune impacts on the brain and behavior of offspring. Maternal immune activation in mice, rats, nonhuman primates, and other mammalian model species have demonstrated convergent outcomes across methodologies. These outcomes include shifts and/or disruptions in the normal developmental trajectory of molecular and cellular processes in the offspring brain. Prenatal developmental origins are critical to a mechanistic understanding of maternal immune activation-induced alterations to microglia and immune molecules, brain growth and development, synaptic morphology and physiology, and anxiety- and depression-like, sensorimotor, and social behaviors. These phenotypes are relevant to brain functioning across domains and to anxiety and mood disorders, schizophrenia, and autism spectrum disorder, in which they have been identified. By turning a neurodevelopmental lens on this body of work, we emphasize the importance of acute changes to the prenatal offspring brain in fostering a better understanding of potential mechanisms for intervention. Collectively, overlapping results across maternal immune activation studies also highlight the need to examine preclinical offspring neurodevelopment alterations in terms of a multifactorial immune milieu, or immunome, to determine potential mechanisms of psychiatric risk." @default.
• W2889334837 created "2018-09-07" @default.
• W2889334837 creator A5066901683 @default.
• W2889334837 creator A5086563763 @default.
• W2889334837 date "2019-01-01" @default.
• W2889334837 modified "2023-09-29" @default.
• W2889334837 title "Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry" @default.
• W2889334837 cites W1178946776 @default.
• W2889334837 cites W1485248315 @default.
• W2889334837 cites W1548862642 @default.
• W2889334837 cites W1549834980 @default.
• W2889334837 cites W1553582434 @default.
• W2889334837 cites W1785970105 @default.
• W2889334837 cites W1879405512 @default.
• W2889334837 cites W1893408494 @default.
• W2889334837 cites W1918697652 @default.
• W2889334837 cites W1965916291 @default.
• W2889334837 cites W1966773673 @default.
• W2889334837 cites W1969235931 @default.
• W2889334837 cites W1970756199 @default.
• W2889334837 cites W1975996377 @default.
• W2889334837 cites W1977174983 @default.
• W2889334837 cites W1980789245 @default.
• W2889334837 cites W1981079086 @default.
• W2889334837 cites W1982811887 @default.
• W2889334837 cites W1983141299 @default.
• W2889334837 cites W1984943998 @default.
• W2889334837 cites W1986281170 @default.
• W2889334837 cites W1986974750 @default.
• W2889334837 cites W1987097017 @default.
• W2889334837 cites W1988924673 @default.
• W2889334837 cites W1988993009 @default.
• W2889334837 cites W1990999239 @default.
• W2889334837 cites W1991899211 @default.
• W2889334837 cites W1992902151 @default.
• W2889334837 cites W1994600097 @default.
• W2889334837 cites W1994849223 @default.
• W2889334837 cites W1996059296 @default.
• W2889334837 cites W1999069947 @default.
• W2889334837 cites W2003085573 @default.
• W2889334837 cites W2003215052 @default.
• W2889334837 cites W2003710864 @default.
• W2889334837 cites W2008398629 @default.
• W2889334837 cites W2011085253 @default.
• W2889334837 cites W2015419107 @default.
• W2889334837 cites W2019921978 @default.
• W2889334837 cites W2020342943 @default.
• W2889334837 cites W2021909736 @default.
• W2889334837 cites W2024028366 @default.
• W2889334837 cites W2024510213 @default.
• W2889334837 cites W2024622507 @default.
• W2889334837 cites W2024721963 @default.
• W2889334837 cites W2025570702 @default.
• W2889334837 cites W2025691192 @default.
• W2889334837 cites W2028816846 @default.
• W2889334837 cites W2028983214 @default.
• W2889334837 cites W2029190354 @default.
• W2889334837 cites W2031628476 @default.
• W2889334837 cites W2032516641 @default.
• W2889334837 cites W2034427457 @default.
• W2889334837 cites W2037555832 @default.
• W2889334837 cites W2037577798 @default.
• W2889334837 cites W2038448643 @default.
• W2889334837 cites W2040408325 @default.
• W2889334837 cites W2041442674 @default.
• W2889334837 cites W2041812587 @default.
• W2889334837 cites W2044024220 @default.
• W2889334837 cites W2047804751 @default.
• W2889334837 cites W2048968562 @default.
• W2889334837 cites W2049392449 @default.
• W2889334837 cites W2052297858 @default.
• W2889334837 cites W2054335925 @default.
• W2889334837 cites W2055091163 @default.
• W2889334837 cites W2056331598 @default.
• W2889334837 cites W2057476473 @default.
• W2889334837 cites W2058093953 @default.
• W2889334837 cites W2060893806 @default.
• W2889334837 cites W2062240346 @default.
• W2889334837 cites W2064046464 @default.
• W2889334837 cites W2064452340 @default.
• W2889334837 cites W2067330387 @default.
• W2889334837 cites W2070438913 @default.
• W2889334837 cites W2071197145 @default.
• W2889334837 cites W2072878021 @default.
• W2889334837 cites W2074663926 @default.
• W2889334837 cites W2075035357 @default.
• W2889334837 cites W2076361525 @default.
• W2889334837 cites W2076644456 @default.
• W2889334837 cites W2077888878 @default.
• W2889334837 cites W2079921613 @default.
• W2889334837 cites W2082955509 @default.
• W2889334837 cites W2084022545 @default.
• W2889334837 cites W2085198610 @default.
• W2889334837 cites W2087685632 @default.
• W2889334837 cites W2088683355 @default.
• W2889334837 cites W2092931973 @default.
• W2889334837 cites W2098597355 @default.
• W2889334837 cites W2104000439 @default.

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