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- W2889341191 endingPage "1495" @default.
- W2889341191 startingPage "1486" @default.
- W2889341191 abstract "Overwhelming evidence demonstrates that exosomes, a series of biologically functional small vesicles of endocytic origin carrying a variety of active constituents, especially tumor-derived exosomes, contribute to tumor progression and metastasis. This review focuses on the specific multifaceted roles of exosomes in affecting sequenced four crucial processes of metastasis, through which cancer cells spread from primary to secondary organs and finally form macroscopic metastatic lesions. First, exosomes modulate the primary tumor sites to assist cancer growth and dissemination. In this part, five main biological events are reviewed, including the transfer of oncogenic constituents, the recruitment and activation of fibroblasts, the induction of angiogenesis, immunosuppression and epithelial-mesenchymal transition (EMT) promotion. In Step 2, we list two recently disclosed mechanisms during the organ-specific homing process: the exosomal integrin model and exosomal epidermal growth factor receptor (EGFR)/miR-26/hepatocyte growth factor (HGF) model. Subsequently, Step 3 focuses on the interactions between exosomes and pre-metastatic niche, in which we highlight the specific functions of exosomes in angiogenesis, lymphangiogenesis, immune modulation and metabolic, epigenetic and stromal reprogramming of pre-metastatic niche. Finally, we summarize the mechanisms of exosomes in helping the metastatic circulating tumor cells escape from immunologic surveillance, survive in the blood circulation and proliferate in host organs." @default.
- W2889341191 created "2018-09-07" @default.
- W2889341191 creator A5059605240 @default.
- W2889341191 creator A5062972206 @default.
- W2889341191 creator A5077399736 @default.
- W2889341191 creator A5080793835 @default.
- W2889341191 creator A5085085373 @default.
- W2889341191 date "2018-11-04" @default.
- W2889341191 modified "2023-10-16" @default.
- W2889341191 title "Exosomes play roles in sequential processes of tumor metastasis" @default.
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