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- W2889352238 abstract "Heparin has been reported to inhibit platelet aggregation. Our studies show that this activity is easily demonstrable in washed platelet systems, but fails to occur in citrated platelet-rich plasma (PRP) in the presence of a variety of agonists, except collagen. Studies were performed to answer the following questions: (1) Why does heparin inhibit the aggregation of washed platelets but not of citrated PRP, which is the system commonly used for platelet aggregation studies? (2) What is the effect of heparin on platelet aggregation occurring in whole blood, where it can be examined both with and without the presence of sodium citrate? (3) Why does heparin consistently inhibit the collagen-induced aggregation even in citrated PRP, while it fails to inhibit aggregation caused by other agonists? Results of the studies clearly demonstrated that heparin has the ability to directly react with sodium citrate, causing loss of its inhibitory activity on platelets. The antiaggregatory activity of heparin in the presence of collagen as the agonists appears to be directly related to the blocking of collagen’s agonist activity by heparin. Small concentrations of heparin which were unable to inhibit aggregation per se, effectively blocked the collagen agonist activity on platelet aggregation when heparin was directly added to collagen. Further studies showed that heparin, in a native whole blood platelet aggregation system (in the absence of any anticoagulant), exhibited significant inhibitory activity. This activity was lost when citrate was present in the whole blood preparation. These studies, therefore, indicate that failure of heparin to inhibit platelet aggregation in citrated PRP does not negate the importance of this inhibitory activity. Reactivity of heparin with sodium citrate renders citrated systems unsuitable for studying heparin's effect upon platelets. The whole blood platelet aggregation system without the presence of anticoagulants appears to be a more suitable system for the study of heparin and platelet aggregation, and is closer to the physiological system. Heparin exhibits marked inhibitory activity on platelet aggregation in this system, and this suggests it may be an important activity which deserves further attention." @default.
- W2889352238 created "2018-09-07" @default.
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- W2889352238 date "1987-01-01" @default.
- W2889352238 modified "2023-09-23" @default.
- W2889352238 title "EFFECT OF COLLAGEN AND CITRATE ON HEPARIN-HEDIATED PLATELET ANTIAGGREGATORY ACTIVITY" @default.
- W2889352238 doi "https://doi.org/10.1055/s-0038-1642869" @default.
- W2889352238 hasPublicationYear "1987" @default.
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