FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889361877> ?p ?o ?g. }

• W2889361877 abstract "Abstract Despite the conserved function of aggression across taxa in obtaining critical resources such as food and mates, serotonin’s (5-HT) modulatory role on aggressive behavior appears to be largely inhibitory for vertebrates but stimulatory for invertebrates. However, critical gaps exist in our knowledge of invertebrates that need to be addressed before definitively stating opposing roles for 5-HT and aggression. Specifically, the role of 5-HT receptor subtypes are largely unknown, as is the potential interactive role of 5-HT with other neurochemical systems known to play a critical role in aggression. Similarly, the influence of these systems in driving sex differences in aggressive behavior of invertebrates is not well understood. Here, we investigated these questions by employing complementary approaches in a novel invertebrate model of aggression, the stalk-eyed fly. A combination of altered social conditions, pharmacological manipulation and 5-HT 2 receptor knockdown by siRNA revealed an inhibitory role of this receptor subtype on aggression. Additionally, we provide evidence for 5-HT 2 ’s involvement in regulating neuropeptide F activity, a suspected inhibitor of aggression. However, this function appears to be stage-specific, altering only the initiation stage of aggressive conflicts. Alternatively, pharmacologically increasing systemic concentrations of 5-HT significantly elevated the expression of the neuropeptide tachykinin, which did not affect contest initiation but instead promoted escalation via production of high intensity aggressive behaviors. Notably, these effects were limited solely to males, with female aggression and neuropeptide expression remaining unaltered by any manipulation that affected 5-HT. Together, these results demonstrate a more nuanced role for 5-HT in modulating aggression in invertebrates, revealing an important interactive role with neuropeptides that is more reminiscent of vertebrates. The sex-differences described here also provide valuable insight into the evolutionary contexts of this complex behavior. Significance Statement Serotonin’s (5-HT) modulatory role in aggression is generally reported as inhibitory in vertebrates but stimulatory in invertebrates. Using a novel invertebrate model system, we provide evidence of common pathways of aggression at the 5-HT receptor subtype level as well as 5-HT’s interactive role with other neurochemical systems namely neuropeptide F and tachykinin. Additionally, we found that these effects were sex-dependent as well as stage-dependent affecting either the initiation or escalation stage of an aggressive contest. Our results reveal the impressive level of conservation with respect to neurochemical mechanisms among species as diverse as vertebrates and invertebrates, and highlights the need to consider multiple factors when determining potential taxonomic differences in how 5-HT mediates aggression." @default.
• W2889361877 created "2018-09-07" @default.
• W2889361877 creator A5004738900 @default.
• W2889361877 creator A5011242714 @default.
• W2889361877 creator A5019375440 @default.
• W2889361877 creator A5052925389 @default.
• W2889361877 creator A5073931470 @default.
• W2889361877 creator A5079315427 @default.
• W2889361877 creator A5080871841 @default.
• W2889361877 creator A5082079525 @default.
• W2889361877 date "2018-09-03" @default.
• W2889361877 modified "2023-09-26" @default.
• W2889361877 title "Sex Differences in Aggression: Differential Roles of 5-HT2, Neuropeptide F and Tachykinin" @default.
• W2889361877 cites W176153765 @default.
• W2889361877 cites W1973756587 @default.
• W2889361877 cites W1975970936 @default.
• W2889361877 cites W1976850199 @default.
• W2889361877 cites W1978220073 @default.
• W2889361877 cites W1981024231 @default.
• W2889361877 cites W1984154573 @default.
• W2889361877 cites W1985098185 @default.
• W2889361877 cites W1985744851 @default.
• W2889361877 cites W1987692590 @default.
• W2889361877 cites W1988418074 @default.
• W2889361877 cites W1993444614 @default.
• W2889361877 cites W1996187894 @default.
• W2889361877 cites W1997793201 @default.
• W2889361877 cites W1998970025 @default.
• W2889361877 cites W1999672448 @default.
• W2889361877 cites W2001119798 @default.
• W2889361877 cites W2003810563 @default.
• W2889361877 cites W2005526530 @default.
• W2889361877 cites W2006668156 @default.
• W2889361877 cites W2006686234 @default.
• W2889361877 cites W2009846865 @default.
• W2889361877 cites W2011350628 @default.
• W2889361877 cites W2011620893 @default.
• W2889361877 cites W2022509547 @default.
• W2889361877 cites W2038699893 @default.
• W2889361877 cites W2038817013 @default.
• W2889361877 cites W2042140148 @default.
• W2889361877 cites W2053296459 @default.
• W2889361877 cites W2054221658 @default.
• W2889361877 cites W2055191459 @default.
• W2889361877 cites W2055820126 @default.
• W2889361877 cites W2061541290 @default.
• W2889361877 cites W2062634104 @default.
• W2889361877 cites W2063973028 @default.
• W2889361877 cites W2064695604 @default.
• W2889361877 cites W2068331905 @default.
• W2889361877 cites W2076965386 @default.
• W2889361877 cites W2079019440 @default.
• W2889361877 cites W2082010356 @default.
• W2889361877 cites W2083342484 @default.
• W2889361877 cites W2089049622 @default.
• W2889361877 cites W2092372427 @default.
• W2889361877 cites W2093394408 @default.
• W2889361877 cites W2103668696 @default.
• W2889361877 cites W2109300700 @default.
• W2889361877 cites W2109799814 @default.
• W2889361877 cites W2114570899 @default.
• W2889361877 cites W2117090355 @default.
• W2889361877 cites W2125930065 @default.
• W2889361877 cites W2126717850 @default.
• W2889361877 cites W2134346308 @default.
• W2889361877 cites W2144640180 @default.
• W2889361877 cites W2161201097 @default.
• W2889361877 cites W2161247951 @default.
• W2889361877 cites W2165298007 @default.
• W2889361877 cites W2184711872 @default.
• W2889361877 cites W2250960806 @default.
• W2889361877 cites W2309161784 @default.
• W2889361877 cites W2336639093 @default.
• W2889361877 cites W2550674931 @default.
• W2889361877 cites W4251223727 @default.
• W2889361877 cites W4293247451 @default.
• W2889361877 doi "https://doi.org/10.1101/407478" @default.
• W2889361877 hasPublicationYear "2018" @default.
• W2889361877 type Work @default.
• W2889361877 sameAs 2889361877 @default.
• W2889361877 citedByCount "0" @default.
• W2889361877 crossrefType "posted-content" @default.
• W2889361877 hasAuthorship W2889361877A5004738900 @default.
• W2889361877 hasAuthorship W2889361877A5011242714 @default.
• W2889361877 hasAuthorship W2889361877A5019375440 @default.
• W2889361877 hasAuthorship W2889361877A5052925389 @default.
• W2889361877 hasAuthorship W2889361877A5073931470 @default.
• W2889361877 hasAuthorship W2889361877A5079315427 @default.
• W2889361877 hasAuthorship W2889361877A5080871841 @default.
• W2889361877 hasAuthorship W2889361877A5082079525 @default.
• W2889361877 hasBestOaLocation W28893618771 @default.
• W2889361877 hasConcept C118303440 @default.
• W2889361877 hasConcept C126322002 @default.
• W2889361877 hasConcept C1337776 @default.
• W2889361877 hasConcept C138496976 @default.
• W2889361877 hasConcept C15744967 @default.
• W2889361877 hasConcept C169760540 @default.
• W2889361877 hasConcept C170493617 @default.
• W2889361877 hasConcept C2775864247 @default.
• W2889361877 hasConcept C2779448149 @default.

• next