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• W2889379713 abstract "Screening of a marine natural products library for inhibitors of TGF-β revealed five pyrimidinedione derivatives, biemamides A-E (1-5). The structures were determined by 2D NMR and HRMS experiments; absolute configurations were established by advanced Marfey's analysis and ECD calculations. Biemamides A-E specifically inhibited in vitro TGF-β induced epithelial to mesenchymal transition in NMuMG cells. Additionally, using Caenorhabditis elegans, selected biemmamides were found to influence in vivo developmental processes related to body size regulation in a dose-dependent manner." @default.
• W2889379713 created "2018-09-07" @default.
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• W2889379713 date "2018-08-30" @default.
• W2889379713 modified "2023-10-05" @default.
• W2889379713 title "Biemamides A–E, Inhibitors of the TGF-β Pathway That Block the Epithelial to Mesenchymal Transition" @default.
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• W2889379713 doi "https://doi.org/10.1021/acs.orglett.8b01871" @default.
• W2889379713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6207949" @default.
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