Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889467068> ?p ?o ?g. }
- W2889467068 endingPage "232" @default.
- W2889467068 startingPage "222" @default.
- W2889467068 abstract "The intrinsic humoral immunodeficiency of chronic lymphocytic leukemia (CLL) is often managed with immunoglobulin replacement therapy (IgRT) to maintain IgG levels in the low-normal range (6–8 g/L) but optimal targets for IgG and timing to commence IgRT are unclear. IgG levels fell near 6 g/L at rates of −0.85±0.14 g/L/year in 51 patients who required treatment for CLL within 4.5±0.4 years from initial diagnosis and − 0.27±0.04 g/L/year in 40 patients with progressive disease who remained untreated after 8.5±0.5 years. In contrast, endogenous IgG levels remained above 8 g/L in patients with highly indolent disease (n = 25) and TNFα and beta-2-microglobulin (β2M) in blood decreased when IgRT was used to increase IgG levels over 9 g/L. At 15 g/L but not 5 g/L, the IgRT product Hizentra® inhibited B cell receptor (BCR)-activation, TNFα production, and survival in vitro, particularly of CLL cells that spontaneously made little TNFα. These findings suggest deterioration of the humoral immune system is associated with progressive CLL and altering the dosing of IgRT to achieve higher than conventional IgG target levels may have therapeutic activity." @default.
- W2889467068 created "2018-09-07" @default.
- W2889467068 creator A5035575874 @default.
- W2889467068 creator A5041368786 @default.
- W2889467068 creator A5051534286 @default.
- W2889467068 creator A5059526418 @default.
- W2889467068 creator A5084119252 @default.
- W2889467068 creator A5090572927 @default.
- W2889467068 creator A5091653815 @default.
- W2889467068 date "2018-09-01" @default.
- W2889467068 modified "2023-10-14" @default.
- W2889467068 title "Association of blood IgG with tumor necrosis factor-alpha and clinical course of chronic lymphocytic leukemia" @default.
- W2889467068 cites W1532384917 @default.
- W2889467068 cites W1557367249 @default.
- W2889467068 cites W1563255069 @default.
- W2889467068 cites W1901654115 @default.
- W2889467068 cites W1949741502 @default.
- W2889467068 cites W1974946636 @default.
- W2889467068 cites W1977978637 @default.
- W2889467068 cites W1981225103 @default.
- W2889467068 cites W1986464292 @default.
- W2889467068 cites W1996462580 @default.
- W2889467068 cites W1999588603 @default.
- W2889467068 cites W2003244776 @default.
- W2889467068 cites W2006294701 @default.
- W2889467068 cites W2008308389 @default.
- W2889467068 cites W2008591960 @default.
- W2889467068 cites W2032553162 @default.
- W2889467068 cites W2050301611 @default.
- W2889467068 cites W2056772662 @default.
- W2889467068 cites W2057686471 @default.
- W2889467068 cites W2061351840 @default.
- W2889467068 cites W2061848933 @default.
- W2889467068 cites W2068953587 @default.
- W2889467068 cites W2070731070 @default.
- W2889467068 cites W2087313435 @default.
- W2889467068 cites W2091664866 @default.
- W2889467068 cites W2101844301 @default.
- W2889467068 cites W2104154119 @default.
- W2889467068 cites W2108374688 @default.
- W2889467068 cites W2144005181 @default.
- W2889467068 cites W2148744460 @default.
- W2889467068 cites W2157965726 @default.
- W2889467068 cites W2195033221 @default.
- W2889467068 cites W2205932975 @default.
- W2889467068 cites W2208017095 @default.
- W2889467068 cites W2286356945 @default.
- W2889467068 cites W2295530774 @default.
- W2889467068 cites W2328998233 @default.
- W2889467068 cites W2330505390 @default.
- W2889467068 cites W2469541301 @default.
- W2889467068 cites W2498956233 @default.
- W2889467068 cites W2559590288 @default.
- W2889467068 cites W2564714625 @default.
- W2889467068 cites W2604412029 @default.
- W2889467068 cites W2623503441 @default.
- W2889467068 cites W2790385276 @default.
- W2889467068 cites W2797175556 @default.
- W2889467068 cites W4249140854 @default.
- W2889467068 doi "https://doi.org/10.1016/j.ebiom.2018.08.045" @default.
- W2889467068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156707" @default.
- W2889467068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30174282" @default.
- W2889467068 hasPublicationYear "2018" @default.
- W2889467068 type Work @default.
- W2889467068 sameAs 2889467068 @default.
- W2889467068 citedByCount "7" @default.
- W2889467068 countsByYear W28894670682018 @default.
- W2889467068 countsByYear W28894670682020 @default.
- W2889467068 countsByYear W28894670682021 @default.
- W2889467068 countsByYear W28894670682022 @default.
- W2889467068 countsByYear W28894670682023 @default.
- W2889467068 crossrefType "journal-article" @default.
- W2889467068 hasAuthorship W2889467068A5035575874 @default.
- W2889467068 hasAuthorship W2889467068A5041368786 @default.
- W2889467068 hasAuthorship W2889467068A5051534286 @default.
- W2889467068 hasAuthorship W2889467068A5059526418 @default.
- W2889467068 hasAuthorship W2889467068A5084119252 @default.
- W2889467068 hasAuthorship W2889467068A5090572927 @default.
- W2889467068 hasAuthorship W2889467068A5091653815 @default.
- W2889467068 hasBestOaLocation W28894670681 @default.
- W2889467068 hasConcept C126322002 @default.
- W2889467068 hasConcept C159654299 @default.
- W2889467068 hasConcept C17991360 @default.
- W2889467068 hasConcept C203014093 @default.
- W2889467068 hasConcept C2777701055 @default.
- W2889467068 hasConcept C2777938653 @default.
- W2889467068 hasConcept C2778461978 @default.
- W2889467068 hasConcept C2780898057 @default.
- W2889467068 hasConcept C71924100 @default.
- W2889467068 hasConcept C8891405 @default.
- W2889467068 hasConceptScore W2889467068C126322002 @default.
- W2889467068 hasConceptScore W2889467068C159654299 @default.
- W2889467068 hasConceptScore W2889467068C17991360 @default.
- W2889467068 hasConceptScore W2889467068C203014093 @default.
- W2889467068 hasConceptScore W2889467068C2777701055 @default.
- W2889467068 hasConceptScore W2889467068C2777938653 @default.
- W2889467068 hasConceptScore W2889467068C2778461978 @default.
- W2889467068 hasConceptScore W2889467068C2780898057 @default.