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- W2889473464 abstract "An original observation of platelet agglutination was found in a 63 y.o. man during 5 years following, without spontaneous bleeding. Low platelet counts (10 × 109/liter) and large agglutinates were observed on blood specimens collected into EDTA (1 to 15 mg/ml whole blood WB), citrate (1/10 volume citrate 0.11 M), sodium heparin (100 units/ml WB), citrate plus acetyl salicylic acid (5 to 100 mg/ml WB), citrate plus prostacyclin (Upjohn 10−5 to 10−6 M)? and buffering anticoagulant (0.8 M citrate, pH 4.65). Low platelet count and large agglutinates were also observed in capillary blood obtained by finger puncture kept at 22° or 37°C. All techniques revealed significant clumping making assessment of overall platelet number impossible. Bleeding time Ivy horizontal incision is longer than 20 minutes. Patient's serum induced normal platelets agglutination up to a 1/512 dilution at 22°and 37°C temperature. Lack of agglutination after treatment of the serum by IgM and indirect immunofluorescence tests identified the IgM nature of the agglutinating factor. This antibody reacted with Glanzmann thrombasthenia platelets ruling out the IIb/IIIa complex as the target of this agglutinin. There was no evidence of platelet activation following agglutination of autologous or alldgenic platelets : electronic microscopy of native blood platelets clumps did not show any sign of activation, and plasma level of B-thromboglobulin was normal in this patient. Normal platelets agglutination by patient's serum was not accompanied with ATP secretion (luciferin-luciferase). This IgM agglutinin was associated with elevation of IgM (700 mg/dl) without clinical or biological signs of auto-immune disease. No similar case with irreversible platelet agglutination in both capillary or venous blood has been reported before. The significance of the observation remains obscure." @default.
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- W2889473464 date "1987-01-01" @default.
- W2889473464 modified "2023-09-27" @default.
- W2889473464 title "PSEUDO-THROMBOCYTOPENIA ASSOCIATED WITH AN ANTICOAGULANT INDEPENDENT IgM PLATELET AGGLUTININ IN A PATIENT WITH PROLONGED BLEEDING TIME" @default.
- W2889473464 doi "https://doi.org/10.1055/s-0038-1643975" @default.
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