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- W2889478860 endingPage "122" @default.
- W2889478860 startingPage "85" @default.
- W2889478860 abstract "The glucocorticoid receptor gene (NR3C1) is a critical component of the stress response system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and mental disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders, suggesting that NR3C1 methylation may play a role in stress-related psychopathology. We systematically reviewed 55 studies examining NR3C1 DNA methylation in association with trauma exposure, psychopathology, gene expression, and/or common genetic variants. Overall, a number of NR3C1 CpG sites were significantly associated with trauma or psychopathology, but significant findings were often inconsistent across studies. This lack of consistency is likely influenced by significant methodological variability - experimentally and analytically - across studies. Selected common genetic variants show no significant effect on NR3C1 CpG methylation. In contrast, there was ample evidence linking increased methylation of NR3C1 to reduced expression of this gene. The inverse association between methylation and gene expression shown across eight out of ten studies supports the notion that methylation in the promoter region of NR3C1 is associated with transcriptional silencing." @default.
- W2889478860 created "2018-09-07" @default.
- W2889478860 creator A5035459587 @default.
- W2889478860 creator A5039746461 @default.
- W2889478860 creator A5045381374 @default.
- W2889478860 creator A5064016573 @default.
- W2889478860 creator A5086121026 @default.
- W2889478860 date "2018-12-01" @default.
- W2889478860 modified "2023-09-29" @default.
- W2889478860 title "Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review" @default.
- W2889478860 cites W1136951987 @default.
- W2889478860 cites W1485415382 @default.
- W2889478860 cites W1516864513 @default.
- W2889478860 cites W1520957638 @default.
- W2889478860 cites W1840860792 @default.
- W2889478860 cites W1860638429 @default.
- W2889478860 cites W1890713445 @default.
- W2889478860 cites W1913150253 @default.
- W2889478860 cites W1954266813 @default.
- W2889478860 cites W1960033715 @default.
- W2889478860 cites W1975252054 @default.
- W2889478860 cites W1977000691 @default.
- W2889478860 cites W1981048160 @default.
- W2889478860 cites W1982232439 @default.
- W2889478860 cites W1983954953 @default.
- W2889478860 cites W1984012778 @default.
- W2889478860 cites W1987375729 @default.
- W2889478860 cites W1987557775 @default.
- W2889478860 cites W1994950269 @default.
- W2889478860 cites W1996039965 @default.
- W2889478860 cites W1999272870 @default.
- W2889478860 cites W2001711719 @default.
- W2889478860 cites W2008523946 @default.
- W2889478860 cites W2024455218 @default.
- W2889478860 cites W2027153593 @default.
- W2889478860 cites W2029526731 @default.
- W2889478860 cites W2032068392 @default.
- W2889478860 cites W2039593919 @default.
- W2889478860 cites W2043227725 @default.
- W2889478860 cites W2043583999 @default.
- W2889478860 cites W2044279458 @default.
- W2889478860 cites W2048551934 @default.
- W2889478860 cites W2050515043 @default.
- W2889478860 cites W2062722848 @default.
- W2889478860 cites W2065020285 @default.
- W2889478860 cites W2065709405 @default.
- W2889478860 cites W2069209445 @default.
- W2889478860 cites W2073123191 @default.
- W2889478860 cites W2073278098 @default.
- W2889478860 cites W2076519106 @default.
- W2889478860 cites W2077246048 @default.
- W2889478860 cites W2082474080 @default.
- W2889478860 cites W2085667350 @default.
- W2889478860 cites W2092916960 @default.
- W2889478860 cites W2098597355 @default.
- W2889478860 cites W2102926673 @default.
- W2889478860 cites W2105167570 @default.
- W2889478860 cites W2106670153 @default.
- W2889478860 cites W2113647082 @default.
- W2889478860 cites W2114620191 @default.
- W2889478860 cites W2115117609 @default.
- W2889478860 cites W2116629441 @default.
- W2889478860 cites W2117347068 @default.
- W2889478860 cites W2118374327 @default.
- W2889478860 cites W2118812285 @default.
- W2889478860 cites W2122732537 @default.
- W2889478860 cites W2123032740 @default.
- W2889478860 cites W2125700595 @default.
- W2889478860 cites W2128016314 @default.
- W2889478860 cites W2128148007 @default.
- W2889478860 cites W2128330079 @default.
- W2889478860 cites W2130667602 @default.
- W2889478860 cites W2133469113 @default.
- W2889478860 cites W2137209519 @default.
- W2889478860 cites W2143923606 @default.
- W2889478860 cites W2145864819 @default.
- W2889478860 cites W2148337554 @default.
- W2889478860 cites W2149016179 @default.
- W2889478860 cites W2149472336 @default.
- W2889478860 cites W2152715926 @default.
- W2889478860 cites W2155471840 @default.
- W2889478860 cites W2157255715 @default.
- W2889478860 cites W2157535100 @default.
- W2889478860 cites W2158163151 @default.
- W2889478860 cites W2158809703 @default.
- W2889478860 cites W2164136574 @default.
- W2889478860 cites W2170760271 @default.
- W2889478860 cites W2170887582 @default.
- W2889478860 cites W2206368938 @default.
- W2889478860 cites W2228164136 @default.
- W2889478860 cites W2252365541 @default.
- W2889478860 cites W2255522578 @default.
- W2889478860 cites W2264089163 @default.
- W2889478860 cites W2304339492 @default.
- W2889478860 cites W2316537321 @default.
- W2889478860 cites W2340426429 @default.
- W2889478860 cites W2345554372 @default.
- W2889478860 cites W2412295598 @default.