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- W2889495117 abstract "Fibrillization of α-synuclein is instrumental for the development of Parkinson's disease (PD), thus modulating this process can have profound impact on disease initiation/progression. Here, the impact of the p.G2019S mutation of leucine-rich repeat kinase 2 (LRRK2), which is most frequently associated with familial and sporadic PD, on α-synuclein pathology was investigated. G2019S knock-in mice and wild-type controls were injected with a recombinant adeno-associated viral vector serotype 2/9 (AAV2/9) overexpressing human mutant p.A53T α-synuclein (AAV2/9-hα-syn). Control animals were injected with AAV2/9 carrying green fluorescent protein. Motor behavior, transgene expression, α-syn and pSer129 α-syn load, number of nigral dopamine neurons and density of striatal dopaminergic terminals were evaluated. To investigate the effect of aging, experiments were performed in 3- and 12-month-old mice, evaluated 20 and 12 weeks after virus injection, respectively. hα-syn overexpression induced progressive motor deficits, loss of nigral dopaminergic neurons and striatal terminals, and appearance of proteinase K-resistant aggregates of pSer129 α-syn in both young and old mice. Although no genotype difference was observed in 3-month-old mice, degeneration of nigral dopaminergic neurons was higher in 12-month-old G2019S knock-in mice compared with age-matched wild-type controls (-55% vs -39%, respectively). Consistently, a two-fold higher load of pSer129 α-syn aggregates was found in 12-month-old G2019S knock-in mice. We conclude that G2019S LRRK2 facilitates α-synucleinopathy and degeneration of nigral dopaminergic neurons, and that aging is a major determinant of this effect." @default.
- W2889495117 created "2018-09-07" @default.
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- W2889495117 date "2018-12-01" @default.
- W2889495117 modified "2023-10-10" @default.
- W2889495117 title "G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice" @default.
- W2889495117 cites W1496790952 @default.
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- W2889495117 cites W1544196343 @default.
- W2889495117 cites W154777429 @default.
- W2889495117 cites W1605845088 @default.
- W2889495117 cites W1690318953 @default.
- W2889495117 cites W1856731619 @default.
- W2889495117 cites W1910661134 @default.
- W2889495117 cites W1957569525 @default.
- W2889495117 cites W1972931472 @default.
- W2889495117 cites W1979591162 @default.
- W2889495117 cites W1981197366 @default.
- W2889495117 cites W1987155530 @default.
- W2889495117 cites W1989734945 @default.
- W2889495117 cites W1990045885 @default.
- W2889495117 cites W1992365739 @default.
- W2889495117 cites W1992483894 @default.
- W2889495117 cites W1992632425 @default.
- W2889495117 cites W1993869272 @default.
- W2889495117 cites W2001283049 @default.
- W2889495117 cites W2002112986 @default.
- W2889495117 cites W2004185979 @default.
- W2889495117 cites W2031345305 @default.
- W2889495117 cites W2038440451 @default.
- W2889495117 cites W2047565527 @default.
- W2889495117 cites W2051159468 @default.
- W2889495117 cites W2053206193 @default.
- W2889495117 cites W2063127941 @default.
- W2889495117 cites W2064755557 @default.
- W2889495117 cites W2066106031 @default.
- W2889495117 cites W2067705214 @default.
- W2889495117 cites W2068231672 @default.
- W2889495117 cites W2068288454 @default.
- W2889495117 cites W2074555768 @default.
- W2889495117 cites W2084334114 @default.
- W2889495117 cites W2090905739 @default.
- W2889495117 cites W2098507974 @default.
- W2889495117 cites W2099872441 @default.
- W2889495117 cites W2100300726 @default.
- W2889495117 cites W2100894616 @default.
- W2889495117 cites W2103454698 @default.
- W2889495117 cites W2108865709 @default.
- W2889495117 cites W2116510706 @default.
- W2889495117 cites W2117503265 @default.
- W2889495117 cites W2117626437 @default.
- W2889495117 cites W2123094625 @default.
- W2889495117 cites W2123431154 @default.
- W2889495117 cites W2130968058 @default.
- W2889495117 cites W2138340505 @default.
- W2889495117 cites W2139451088 @default.
- W2889495117 cites W2141459724 @default.
- W2889495117 cites W2143811842 @default.
- W2889495117 cites W2147495484 @default.
- W2889495117 cites W2149602553 @default.
- W2889495117 cites W2150656456 @default.
- W2889495117 cites W2157765536 @default.
- W2889495117 cites W2171114341 @default.
- W2889495117 cites W2195696457 @default.
- W2889495117 cites W2205544783 @default.
- W2889495117 cites W2272018291 @default.
- W2889495117 cites W2472421578 @default.
- W2889495117 cites W2476283992 @default.
- W2889495117 cites W2560138349 @default.
- W2889495117 cites W2585596724 @default.
- W2889495117 cites W2596654147 @default.
- W2889495117 cites W2745164635 @default.
- W2889495117 cites W2752143278 @default.
- W2889495117 cites W2755670910 @default.
- W2889495117 cites W2756232480 @default.
- W2889495117 cites W2761522803 @default.
- W2889495117 cites W2771146782 @default.
- W2889495117 cites W2792669547 @default.
- W2889495117 cites W2803478714 @default.
- W2889495117 cites W4211044101 @default.
- W2889495117 doi "https://doi.org/10.1016/j.nbd.2018.08.018" @default.
- W2889495117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30172844" @default.
- W2889495117 hasPublicationYear "2018" @default.
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