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• W2889513579 endingPage "2559" @default.
• W2889513579 startingPage "2559" @default.
• W2889513579 abstract "Mechanical forces in blood circulation such as shear stress play a predominant role in many physiological and pathophysiological processes related to vascular responses or vessel remodeling. Arteriogenesis, defined as the growth of pre-existing arterioles into functional collateral arteries compensating for stenosed or occluded arteries, is such a process. Midkine, a pleiotropic protein and growth factor, has originally been identified to orchestrate embryonic development. In the adult organism its expression is restricted to distinct tissues (including tumors), whereby midkine is strongly expressed in inflamed tissue and has been shown to promote inflammation. Recent investigations conferred midkine an important function in vascular remodeling and growth. In this review, we introduce the midkine gene and protein along with its cognate receptors, and highlight its role in inflammation and the vascular system with special emphasis on arteriogenesis, particularly focusing on shear stress-mediated vascular cell proliferation and vasodilatation." @default.
• W2889513579 created "2018-09-07" @default.
• W2889513579 creator A5048716653 @default.
• W2889513579 creator A5069421991 @default.
• W2889513579 creator A5088259499 @default.
• W2889513579 date "2018-08-29" @default.
• W2889513579 modified "2023-09-29" @default.
• W2889513579 title "The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation" @default.
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