FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889551486> ?p ?o ?g. }

• W2889551486 abstract "The molecular states of ketoprofen and the interaction between ketoprofen and other pharmaceutical excipients in the matrix layer were examined to determine their effect on the pharmaceutical properties of original and generic ketoprofen dermal patches (generic patches A and B). Molecular states of ketoprofen were evaluated using polarized light microscopy, Raman spectroscopy and powder X-ray diffraction. For the original ketoprofen patch, crystalline components were not observed in the matrix layer. However, crystalline ketoprofen was observed in the two generic ketoprofen patches. Moreover, the ketoprofen exhibited hydrogen bonding with the pharmaceutical excipients or patch materials in the generic products. Skin permeation of ketoprofen from the patches was evaluated using hairless mouse skin. Twelve hours after application, the original patch demonstrated the highest level of cumulative skin permeation of ketoprofen. This was followed by generic patch B while generic patch A showed the lowest level of permeation. Fluxes were calculated from the skin permeation profiles. The original patch was approx. 2.4-times faster compared with generic patch A and approximately 1.9-times faster compared with generic patch B. This investigation suggested that pharmaceutical properties such as skin permeability for these types of products are affected by the precipitation of crystalline ketoprofen in the matrix layer and the interaction of ketoprofen with the pharmaceutical excipients or patch materials." @default.
• W2889551486 created "2018-09-07" @default.
• W2889551486 creator A5002871289 @default.
• W2889551486 creator A5015550264 @default.
• W2889551486 creator A5017584975 @default.
• W2889551486 creator A5021857641 @default.
• W2889551486 creator A5022467637 @default.
• W2889551486 creator A5034828229 @default.
• W2889551486 creator A5048184551 @default.
• W2889551486 creator A5067407925 @default.
• W2889551486 creator A5071421571 @default.
• W2889551486 creator A5071839404 @default.
• W2889551486 date "2018-09-01" @default.
• W2889551486 modified "2023-09-27" @default.
• W2889551486 title "Molecular State of Active Pharmaceutical Ingredients in Ketoprofen Dermal Patches Characterized by Pharmaceutical Evaluation" @default.
• W2889551486 cites W1542599288 @default.
• W2889551486 cites W1655438715 @default.
• W2889551486 cites W1966385056 @default.
• W2889551486 cites W1968665503 @default.
• W2889551486 cites W2008916894 @default.
• W2889551486 cites W2014505705 @default.
• W2889551486 cites W2017291275 @default.
• W2889551486 cites W2029154742 @default.
• W2889551486 cites W2034169366 @default.
• W2889551486 cites W2034700849 @default.
• W2889551486 cites W2039166351 @default.
• W2889551486 cites W2049223264 @default.
• W2889551486 cites W2068101480 @default.
• W2889551486 cites W2072655318 @default.
• W2889551486 cites W2073281162 @default.
• W2889551486 cites W2073978687 @default.
• W2889551486 cites W2079193883 @default.
• W2889551486 cites W2082581830 @default.
• W2889551486 cites W2083368300 @default.
• W2889551486 cites W2092389403 @default.
• W2889551486 cites W2110841334 @default.
• W2889551486 cites W2115431666 @default.
• W2889551486 cites W2127186709 @default.
• W2889551486 cites W2151702186 @default.
• W2889551486 cites W2165670927 @default.
• W2889551486 cites W2512368706 @default.
• W2889551486 cites W2514794564 @default.
• W2889551486 cites W2518198082 @default.
• W2889551486 cites W2590018051 @default.
• W2889551486 doi "https://doi.org/10.1248/bpb.b18-00019" @default.
• W2889551486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30175772" @default.
• W2889551486 hasPublicationYear "2018" @default.
• W2889551486 type Work @default.
• W2889551486 sameAs 2889551486 @default.
• W2889551486 citedByCount "2" @default.
• W2889551486 countsByYear W28895514862019 @default.
• W2889551486 countsByYear W28895514862020 @default.
• W2889551486 crossrefType "journal-article" @default.
• W2889551486 hasAuthorship W2889551486A5002871289 @default.
• W2889551486 hasAuthorship W2889551486A5015550264 @default.
• W2889551486 hasAuthorship W2889551486A5017584975 @default.
• W2889551486 hasAuthorship W2889551486A5021857641 @default.
• W2889551486 hasAuthorship W2889551486A5022467637 @default.
• W2889551486 hasAuthorship W2889551486A5034828229 @default.
• W2889551486 hasAuthorship W2889551486A5048184551 @default.
• W2889551486 hasAuthorship W2889551486A5067407925 @default.
• W2889551486 hasAuthorship W2889551486A5071421571 @default.
• W2889551486 hasAuthorship W2889551486A5071839404 @default.
• W2889551486 hasBestOaLocation W28895514861 @default.
• W2889551486 hasConcept C185592680 @default.
• W2889551486 hasConcept C205679159 @default.
• W2889551486 hasConcept C2775842315 @default.
• W2889551486 hasConcept C2780744026 @default.
• W2889551486 hasConcept C41625074 @default.
• W2889551486 hasConcept C43617362 @default.
• W2889551486 hasConcept C50670333 @default.
• W2889551486 hasConcept C55493867 @default.
• W2889551486 hasConcept C71924100 @default.
• W2889551486 hasConcept C77281830 @default.
• W2889551486 hasConcept C98274493 @default.
• W2889551486 hasConceptScore W2889551486C185592680 @default.
• W2889551486 hasConceptScore W2889551486C205679159 @default.
• W2889551486 hasConceptScore W2889551486C2775842315 @default.
• W2889551486 hasConceptScore W2889551486C2780744026 @default.
• W2889551486 hasConceptScore W2889551486C41625074 @default.
• W2889551486 hasConceptScore W2889551486C43617362 @default.
• W2889551486 hasConceptScore W2889551486C50670333 @default.
• W2889551486 hasConceptScore W2889551486C55493867 @default.
• W2889551486 hasConceptScore W2889551486C71924100 @default.
• W2889551486 hasConceptScore W2889551486C77281830 @default.
• W2889551486 hasConceptScore W2889551486C98274493 @default.
• W2889551486 hasLocation W28895514861 @default.
• W2889551486 hasLocation W28895514862 @default.
• W2889551486 hasOpenAccess W2889551486 @default.
• W2889551486 hasPrimaryLocation W28895514861 @default.
• W2889551486 hasRelatedWork W1986088386 @default.
• W2889551486 hasRelatedWork W1988302636 @default.
• W2889551486 hasRelatedWork W1996151977 @default.
• W2889551486 hasRelatedWork W2024637950 @default.
• W2889551486 hasRelatedWork W2038327286 @default.
• W2889551486 hasRelatedWork W2043454924 @default.
• W2889551486 hasRelatedWork W2075273548 @default.
• W2889551486 hasRelatedWork W2135729915 @default.
• W2889551486 hasRelatedWork W2382365054 @default.
• W2889551486 hasRelatedWork W2890854556 @default.

• next