Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889591924> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2889591924 abstract "5543 Background: The extent of tumor infiltrating lymphocytes (TILs) has emerged as a potential clinical useful biomarker in epithelial ovarian cancer (OC); however differences in TILs among OC histological types have not been extensively analysed. Methods: From a prospective early stage (I-II) GEICO registry of 1151 cases, 573 were sent for central pathology review. Complete analysis for classification of OC correctly identified 488 cases. Histological typing was performed according to morphological features and the expression of WT1, p53, p16, estrogen receptor (ER), progesterone receptor, and napsin A. The expression of mismatch repair (MMR) proteins MLH1, PMS2, MSH2 and MSH6 was performed in all tumors. The absolute number of stromal and intraepithelial CD8 + TILs per 0.6 mm 2 TMA core was quantified and correlated with pathological features. Results: The series included 127 high-grade serous carcinomas (HGSC) (26%), 22 low-grade serous carcinomas (LGSOC) (4.5%), 165 endometrioid carcinomas (EC) (33.8%), 124 clear cell carcinomas (CCC) (2.4%), and 50 mucinous carcinomas (MC) (10.2%). The mean of intraepithelial CD8 + TILs was higher in HGSG (48.7) than in all other histological types (LGSG: 16.3; EC: 27.1; MC: 7.0; and CCC 10.3; p<0.0001). In the stromal component, the mean of CD8 + TILs was also higher in HGSG (31.1) than in EC, MC and CCC (15.8, 8.0 and 12.7, respectively; p<0.0001). The mean of intraepithelial CD8 + TILs was significantly higher in RE-positive (71.9) than in RE-negative (34.8) HGSC ( p=0.002). In the complete series, 33 (6.6%) OCs showed absent expression of at least 1 MMR protein, and the mean of intraepithelial CD8 + TILs was significantly higher in these OCs (57.0) than in those with preserved expression of all MMR proteins (23.6; p=0.0035). MMR protein deficiency was observed in 27 (16%) ECs, and these tumours had significantly higher mean of both intraepithelial (60.4 vs. 20.7 p=0.003) and stromal CD8+ TILs (26.6 vs. 13.8, p= 0.046). No significant differences in TILs were observed among EC of different histological grades. Conclusions: The extent of CD8 + TILs significantly correlates with the histological type and MMR status in OCs, being HGSCs and EC with MMR deficiency those OCs with higher CD8 + TILs." @default.
- W2889591924 created "2018-09-27" @default.
- W2889591924 creator A5019586191 @default.
- W2889591924 creator A5022934323 @default.
- W2889591924 creator A5033251451 @default.
- W2889591924 creator A5034608715 @default.
- W2889591924 creator A5036285079 @default.
- W2889591924 creator A5046083398 @default.
- W2889591924 creator A5047678330 @default.
- W2889591924 creator A5050902318 @default.
- W2889591924 creator A5060787566 @default.
- W2889591924 creator A5062906019 @default.
- W2889591924 creator A5063706801 @default.
- W2889591924 creator A5066083581 @default.
- W2889591924 creator A5067053417 @default.
- W2889591924 creator A5074334245 @default.
- W2889591924 creator A5077016336 @default.
- W2889591924 creator A5081736939 @default.
- W2889591924 creator A5084036644 @default.
- W2889591924 creator A5085757871 @default.
- W2889591924 creator A5089405899 @default.
- W2889591924 creator A5090159813 @default.
- W2889591924 date "2017-05-20" @default.
- W2889591924 modified "2023-09-22" @default.
- W2889591924 title "CD8+ TILs in early stage epithelial ovarian cancer: A GEICO study." @default.
- W2889591924 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.5543" @default.
- W2889591924 hasPublicationYear "2017" @default.
- W2889591924 type Work @default.
- W2889591924 sameAs 2889591924 @default.
- W2889591924 citedByCount "0" @default.
- W2889591924 crossrefType "journal-article" @default.
- W2889591924 hasAuthorship W2889591924A5019586191 @default.
- W2889591924 hasAuthorship W2889591924A5022934323 @default.
- W2889591924 hasAuthorship W2889591924A5033251451 @default.
- W2889591924 hasAuthorship W2889591924A5034608715 @default.
- W2889591924 hasAuthorship W2889591924A5036285079 @default.
- W2889591924 hasAuthorship W2889591924A5046083398 @default.
- W2889591924 hasAuthorship W2889591924A5047678330 @default.
- W2889591924 hasAuthorship W2889591924A5050902318 @default.
- W2889591924 hasAuthorship W2889591924A5060787566 @default.
- W2889591924 hasAuthorship W2889591924A5062906019 @default.
- W2889591924 hasAuthorship W2889591924A5063706801 @default.
- W2889591924 hasAuthorship W2889591924A5066083581 @default.
- W2889591924 hasAuthorship W2889591924A5067053417 @default.
- W2889591924 hasAuthorship W2889591924A5074334245 @default.
- W2889591924 hasAuthorship W2889591924A5077016336 @default.
- W2889591924 hasAuthorship W2889591924A5081736939 @default.
- W2889591924 hasAuthorship W2889591924A5084036644 @default.
- W2889591924 hasAuthorship W2889591924A5085757871 @default.
- W2889591924 hasAuthorship W2889591924A5089405899 @default.
- W2889591924 hasAuthorship W2889591924A5090159813 @default.
- W2889591924 hasConcept C121608353 @default.
- W2889591924 hasConcept C126322002 @default.
- W2889591924 hasConcept C142724271 @default.
- W2889591924 hasConcept C143998085 @default.
- W2889591924 hasConcept C146357865 @default.
- W2889591924 hasConcept C151730666 @default.
- W2889591924 hasConcept C2780427987 @default.
- W2889591924 hasConcept C29456083 @default.
- W2889591924 hasConcept C2992773878 @default.
- W2889591924 hasConcept C71924100 @default.
- W2889591924 hasConcept C86803240 @default.
- W2889591924 hasConceptScore W2889591924C121608353 @default.
- W2889591924 hasConceptScore W2889591924C126322002 @default.
- W2889591924 hasConceptScore W2889591924C142724271 @default.
- W2889591924 hasConceptScore W2889591924C143998085 @default.
- W2889591924 hasConceptScore W2889591924C146357865 @default.
- W2889591924 hasConceptScore W2889591924C151730666 @default.
- W2889591924 hasConceptScore W2889591924C2780427987 @default.
- W2889591924 hasConceptScore W2889591924C29456083 @default.
- W2889591924 hasConceptScore W2889591924C2992773878 @default.
- W2889591924 hasConceptScore W2889591924C71924100 @default.
- W2889591924 hasConceptScore W2889591924C86803240 @default.
- W2889591924 hasLocation W28895919241 @default.
- W2889591924 hasOpenAccess W2889591924 @default.
- W2889591924 hasPrimaryLocation W28895919241 @default.
- W2889591924 hasRelatedWork W1995949619 @default.
- W2889591924 hasRelatedWork W2176767812 @default.
- W2889591924 hasRelatedWork W2521412203 @default.
- W2889591924 hasRelatedWork W2592442089 @default.
- W2889591924 hasRelatedWork W2602522270 @default.
- W2889591924 hasRelatedWork W2709724660 @default.
- W2889591924 hasRelatedWork W2753911561 @default.
- W2889591924 hasRelatedWork W2796904042 @default.
- W2889591924 hasRelatedWork W2891560139 @default.
- W2889591924 hasRelatedWork W2891577775 @default.
- W2889591924 hasRelatedWork W2912959784 @default.
- W2889591924 hasRelatedWork W2919005308 @default.
- W2889591924 hasRelatedWork W2936242808 @default.
- W2889591924 hasRelatedWork W2954919517 @default.
- W2889591924 hasRelatedWork W2998998101 @default.
- W2889591924 hasRelatedWork W3041161413 @default.
- W2889591924 hasRelatedWork W3086600256 @default.
- W2889591924 hasRelatedWork W3170470402 @default.
- W2889591924 hasRelatedWork W3175965727 @default.
- W2889591924 hasRelatedWork W3193588463 @default.
- W2889591924 isParatext "false" @default.
- W2889591924 isRetracted "false" @default.
- W2889591924 magId "2889591924" @default.
- W2889591924 workType "article" @default.