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• W2889592541 abstract "Abstract Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-retromer assembly for Wntless transport and report that SNX3 associates with an evolutionary conserved endosome-associated membrane re-modelling complex composed of MON2, DOPEY2 and the putative aminophospholipid translocase, ATP9A. In vivo suppression of Ce-mon-2 , Ce-pad-1 or Ce-tat-5 (respective MON2, DOPEY2 and ATP9A orthologues) phenocopy a loss of SNX3-retromer function, leading to enhanced lysosomal degradation of Wntless and a Wnt phenotype. Perturbed Wnt signalling is also observed upon overexpression of an ATPase-inhibited TAT-5(E246Q) mutant, suggesting a role for phospholipid flippase activity during SNX3-retromer-mediated Wntless sorting. Together, these findings provide in vitro and in vivo mechanistic details to describe SNX3-retromer-mediated transport during Wnt secretion and the formation of Wnt-morphogenic gradients." @default.
• W2889592541 created "2018-09-27" @default.
• W2889592541 creator A5018407086 @default.
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• W2889592541 creator A5074653254 @default.
• W2889592541 creator A5075098487 @default.
• W2889592541 date "2018-09-13" @default.
• W2889592541 modified "2023-10-14" @default.
• W2889592541 title "SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion" @default.
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• W2889592541 doi "https://doi.org/10.1038/s41467-018-06114-3" @default.
• W2889592541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6137200" @default.
• W2889592541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213940" @default.
• W2889592541 hasPublicationYear "2018" @default.
• W2889592541 type Work @default.
• W2889592541 sameAs 2889592541 @default.

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