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• W2889597388 abstract "Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during sepsis. TDCA increases the number of granulocytic myeloid-derived suppressor cells (MDSCLT) distinctive from MDSCs obtained without TDCA treatment (MDSCL) in the spleen of septic mice. FACS-sorted MDSCLT cells suppress T-cell proliferation and confer protection against sepsis when adoptively transferred better than MDSCL. Proteogenomic analysis indicated that TDCA controls chromatin silencing, alternative splicing, and translation of the immune proteome of MDSCLT, which increases the expression of anti-inflammatory molecules such as oncostatin, lactoferrin and CD244. TDCA also decreases the expression of pro-inflammatory molecules such as neutrophil elastase. These findings suggest that TDCA globally edits the proteome to increase the number of MDSCLT cells and affect their immune-regulatory functions to resolve systemic inflammation during sepsis." @default.
• W2889597388 created "2018-09-27" @default.
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• W2889597388 date "2018-09-18" @default.
• W2889597388 modified "2023-10-12" @default.
• W2889597388 title "Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice" @default.
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• W2889597388 cites W1652069479 @default.
• W2889597388 cites W1761317375 @default.
• W2889597388 cites W1852294817 @default.
• W2889597388 cites W1901387978 @default.
• W2889597388 cites W1914953479 @default.
• W2889597388 cites W1921518259 @default.
• W2889597388 cites W1926790978 @default.
• W2889597388 cites W1967056255 @default.
• W2889597388 cites W1970224035 @default.
• W2889597388 cites W1970582843 @default.
• W2889597388 cites W1978667507 @default.
• W2889597388 cites W1982230962 @default.
• W2889597388 cites W1984036306 @default.
• W2889597388 cites W1987965851 @default.
• W2889597388 cites W1989111278 @default.
• W2889597388 cites W1991597890 @default.
• W2889597388 cites W2000409833 @default.
• W2889597388 cites W2000832007 @default.
• W2889597388 cites W2004150448 @default.
• W2889597388 cites W2012405690 @default.
• W2889597388 cites W2018716544 @default.
• W2889597388 cites W2021206718 @default.
• W2889597388 cites W2021444563 @default.
• W2889597388 cites W2022279737 @default.
• W2889597388 cites W2022760318 @default.
• W2889597388 cites W2024413980 @default.
• W2889597388 cites W2025873966 @default.
• W2889597388 cites W2026123068 @default.
• W2889597388 cites W2026160870 @default.
• W2889597388 cites W2031282626 @default.
• W2889597388 cites W2048085891 @default.
• W2889597388 cites W2051530350 @default.
• W2889597388 cites W2051795211 @default.
• W2889597388 cites W2053581007 @default.
• W2889597388 cites W2054932354 @default.
• W2889597388 cites W2056032938 @default.
• W2889597388 cites W2056411965 @default.
• W2889597388 cites W2062817574 @default.
• W2889597388 cites W2062855802 @default.
• W2889597388 cites W2064818259 @default.
• W2889597388 cites W2068383535 @default.
• W2889597388 cites W2068748139 @default.
• W2889597388 cites W2073737981 @default.
• W2889597388 cites W2076243684 @default.
• W2889597388 cites W2081028309 @default.
• W2889597388 cites W2085901253 @default.
• W2889597388 cites W2091098625 @default.
• W2889597388 cites W2096180149 @default.
• W2889597388 cites W2096418655 @default.
• W2889597388 cites W2106515170 @default.
• W2889597388 cites W2111051593 @default.
• W2889597388 cites W2118830864 @default.
• W2889597388 cites W2121848003 @default.
• W2889597388 cites W2122440014 @default.
• W2889597388 cites W2130186030 @default.
• W2889597388 cites W2130407782 @default.
• W2889597388 cites W2132822330 @default.
• W2889597388 cites W2133070067 @default.
• W2889597388 cites W2134689623 @default.
• W2889597388 cites W2144347270 @default.
• W2889597388 cites W2145393097 @default.
• W2889597388 cites W2146726439 @default.
• W2889597388 cites W2151579964 @default.
• W2889597388 cites W2152221103 @default.
• W2889597388 cites W2152677909 @default.
• W2889597388 cites W2171398834 @default.
• W2889597388 cites W2191241037 @default.
• W2889597388 cites W2208262108 @default.
• W2889597388 cites W2262060930 @default.

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