Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889597951> ?p ?o ?g. }
- W2889597951 abstract "Abstract The alarming rise of antimicrobial resistance requires antibiotics with unexploited mechanisms. Ideal templates could be antibiotics that target the peptidoglycan precursor lipid II, known as the bacterial Achilles heel, at an irreplaceable pyrophosphate group. Such antibiotics would kill multidrug-resistant pathogens at nanomolecular concentrations without causing antimicrobial resistance. However, due to the challenge of studying small membrane-embedded drug–receptor complexes in native conditions, the structural correlates of the pharmaceutically relevant binding modes are unknown. Here, using advanced highly sensitive solid-state NMR setups, we present a high-resolution approach to study lipid II-binding antibiotics directly in cell membranes. On the example of nisin, the preeminent lantibiotic, we show that the native antibiotic-binding mode strongly differs from previously published structures, and we demonstrate that functional hotspots correspond to plastic drug domains that are critical for the cellular adaptability of nisin. Thereby, our approach provides a foundation for an improved understanding of powerful antibiotics." @default.
- W2889597951 created "2018-09-27" @default.
- W2889597951 creator A5013944488 @default.
- W2889597951 creator A5024449996 @default.
- W2889597951 creator A5027568442 @default.
- W2889597951 creator A5049381929 @default.
- W2889597951 creator A5053440215 @default.
- W2889597951 creator A5067751368 @default.
- W2889597951 creator A5080937302 @default.
- W2889597951 creator A5090824175 @default.
- W2889597951 date "2018-09-27" @default.
- W2889597951 modified "2023-10-15" @default.
- W2889597951 title "High-resolution NMR studies of antibiotics in cellular membranes" @default.
- W2889597951 cites W1581569433 @default.
- W2889597951 cites W1597947286 @default.
- W2889597951 cites W1947808677 @default.
- W2889597951 cites W1968125869 @default.
- W2889597951 cites W1979404035 @default.
- W2889597951 cites W1980145079 @default.
- W2889597951 cites W1985137168 @default.
- W2889597951 cites W1989695304 @default.
- W2889597951 cites W1994495883 @default.
- W2889597951 cites W2000693118 @default.
- W2889597951 cites W2002139133 @default.
- W2889597951 cites W2003709444 @default.
- W2889597951 cites W2012251902 @default.
- W2889597951 cites W2015338014 @default.
- W2889597951 cites W2020016481 @default.
- W2889597951 cites W2026838076 @default.
- W2889597951 cites W2029552800 @default.
- W2889597951 cites W2030053493 @default.
- W2889597951 cites W2032819924 @default.
- W2889597951 cites W2034597926 @default.
- W2889597951 cites W2042120996 @default.
- W2889597951 cites W2043246571 @default.
- W2889597951 cites W2052428861 @default.
- W2889597951 cites W2053377122 @default.
- W2889597951 cites W2054031517 @default.
- W2889597951 cites W2055516309 @default.
- W2889597951 cites W2057547892 @default.
- W2889597951 cites W2098974281 @default.
- W2889597951 cites W2118991174 @default.
- W2889597951 cites W2120631617 @default.
- W2889597951 cites W2125457365 @default.
- W2889597951 cites W2137858757 @default.
- W2889597951 cites W2146325980 @default.
- W2889597951 cites W2148851922 @default.
- W2889597951 cites W2149046116 @default.
- W2889597951 cites W2152311269 @default.
- W2889597951 cites W2152908656 @default.
- W2889597951 cites W2155398486 @default.
- W2889597951 cites W2156749322 @default.
- W2889597951 cites W2158447529 @default.
- W2889597951 cites W2162414164 @default.
- W2889597951 cites W2163834922 @default.
- W2889597951 cites W2171068943 @default.
- W2889597951 cites W2220832120 @default.
- W2889597951 cites W2255557641 @default.
- W2889597951 cites W2286114682 @default.
- W2889597951 cites W2300552860 @default.
- W2889597951 cites W2335572258 @default.
- W2889597951 cites W2415414695 @default.
- W2889597951 cites W2444601377 @default.
- W2889597951 cites W2465975622 @default.
- W2889597951 cites W2524034808 @default.
- W2889597951 cites W2524839899 @default.
- W2889597951 cites W2549768376 @default.
- W2889597951 cites W2585577682 @default.
- W2889597951 cites W2596920681 @default.
- W2889597951 cites W2609081383 @default.
- W2889597951 cites W2610381594 @default.
- W2889597951 cites W2729068001 @default.
- W2889597951 cites W2738810944 @default.
- W2889597951 cites W2782950211 @default.
- W2889597951 doi "https://doi.org/10.1038/s41467-018-06314-x" @default.
- W2889597951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160437" @default.
- W2889597951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262913" @default.
- W2889597951 hasPublicationYear "2018" @default.
- W2889597951 type Work @default.
- W2889597951 sameAs 2889597951 @default.
- W2889597951 citedByCount "84" @default.
- W2889597951 countsByYear W28895979512018 @default.
- W2889597951 countsByYear W28895979512019 @default.
- W2889597951 countsByYear W28895979512020 @default.
- W2889597951 countsByYear W28895979512021 @default.
- W2889597951 countsByYear W28895979512022 @default.
- W2889597951 countsByYear W28895979512023 @default.
- W2889597951 crossrefType "journal-article" @default.
- W2889597951 hasAuthorship W2889597951A5013944488 @default.
- W2889597951 hasAuthorship W2889597951A5024449996 @default.
- W2889597951 hasAuthorship W2889597951A5027568442 @default.
- W2889597951 hasAuthorship W2889597951A5049381929 @default.
- W2889597951 hasAuthorship W2889597951A5053440215 @default.
- W2889597951 hasAuthorship W2889597951A5067751368 @default.
- W2889597951 hasAuthorship W2889597951A5080937302 @default.
- W2889597951 hasAuthorship W2889597951A5090824175 @default.
- W2889597951 hasBestOaLocation W28895979511 @default.
- W2889597951 hasConcept C125235067 @default.
- W2889597951 hasConcept C12554922 @default.
- W2889597951 hasConcept C132141352 @default.