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• W2889637079 abstract "Five previously undescribed 4,5-seco-abietane rearrange diterpenoids (1–5, Prionidipene A-E) were isolated from the aerial parts of Salvia prionitis, along with thirteen known seco-abietane diterpenoids (6–18). The structures of 1–5 were elucidated mainly based on analysis of NMR and MS data. The absolute configurations of 1–3 were determined by evaluation of experimental and calculated electronic circular dichroism (ECD) spectra. Putative biosynthetic pathways toward the formation of 1 and 2 are proposed. The nitric oxide (NO) production inhibitory effects of all isolates in lipopolysaccharide (LPS)-induced in RAW 264.7 cells were evaluated. Interestingly, compounds 4 and 9 with a furan-ring showed potent inhibitory activity with IC50 values of 14.56 and 15.11 μM, respectively." @default.
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• W2889637079 date "2018-12-01" @default.
• W2889637079 modified "2023-10-13" @default.
• W2889637079 title "Bioactive seco-abietane rearranged diterpenoids from the aerial parts of Salvia prionitis" @default.
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• W2889637079 doi "https://doi.org/10.1016/j.bioorg.2018.08.040" @default.
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