Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889639332> ?p ?o ?g. }
- W2889639332 abstract "The disabling degenerative disease osteoarthritis (OA) is prevalent among the global population. Articular cartilage degeneration is a central feature of OA; therefore, a better understanding of the mechanisms that maintain cartilage homeostasis is vital for developing effective therapeutic interventions. MicroRNAs (miRs) modulate cell signaling pathways and various processes in articular cartilage via posttranscriptional repression of target genes. As dysregulated miRs frequently alter the homeostasis of articular cartilage, modulating select miRs presents a potential therapeutic opportunity for OA. Here, we review key miRs that have been shown to modulate cartilage-protective or -destructive mechanisms and signaling pathways. Additionally, we use an integrative computational biology approach to provide insight into predicted miR gene targets that may contribute to OA pathogenesis, and highlight the complexity of miR signaling in OA by generating both unique and overlapping gene targets of miRs that mediate protective or destructive effects. Early OA detection would enable effective prevention; thus, miRs are being explored as diagnostic biomarkers. We discuss these ongoing efforts and the applicability of miR mimics and antisense inhibitors as potential OA therapeutics." @default.
- W2889639332 created "2018-09-27" @default.
- W2889639332 creator A5015256132 @default.
- W2889639332 creator A5045056612 @default.
- W2889639332 creator A5055656807 @default.
- W2889639332 creator A5066040148 @default.
- W2889639332 date "2018-09-06" @default.
- W2889639332 modified "2023-10-12" @default.
- W2889639332 title "The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets" @default.
- W2889639332 cites W1059897138 @default.
- W2889639332 cites W1272499475 @default.
- W2889639332 cites W130207961 @default.
- W2889639332 cites W1493958765 @default.
- W2889639332 cites W1517888762 @default.
- W2889639332 cites W1582503651 @default.
- W2889639332 cites W159357276 @default.
- W2889639332 cites W1669854369 @default.
- W2889639332 cites W1779148953 @default.
- W2889639332 cites W1812430034 @default.
- W2889639332 cites W1931772124 @default.
- W2889639332 cites W1963817121 @default.
- W2889639332 cites W1979206745 @default.
- W2889639332 cites W1980269624 @default.
- W2889639332 cites W1985004392 @default.
- W2889639332 cites W1990435491 @default.
- W2889639332 cites W1991320836 @default.
- W2889639332 cites W1992638032 @default.
- W2889639332 cites W1993990835 @default.
- W2889639332 cites W1995577167 @default.
- W2889639332 cites W1998770186 @default.
- W2889639332 cites W1999382756 @default.
- W2889639332 cites W1999868918 @default.
- W2889639332 cites W2002290633 @default.
- W2889639332 cites W2004763680 @default.
- W2889639332 cites W2005008958 @default.
- W2889639332 cites W2008945738 @default.
- W2889639332 cites W2010916668 @default.
- W2889639332 cites W2013888190 @default.
- W2889639332 cites W2014064723 @default.
- W2889639332 cites W2023836771 @default.
- W2889639332 cites W2024193150 @default.
- W2889639332 cites W2025243746 @default.
- W2889639332 cites W2026099724 @default.
- W2889639332 cites W2027744584 @default.
- W2889639332 cites W2028046200 @default.
- W2889639332 cites W2028089243 @default.
- W2889639332 cites W2031189791 @default.
- W2889639332 cites W2032232359 @default.
- W2889639332 cites W2032735323 @default.
- W2889639332 cites W2036748347 @default.
- W2889639332 cites W2038167014 @default.
- W2889639332 cites W2038773696 @default.
- W2889639332 cites W2041141449 @default.
- W2889639332 cites W2041825143 @default.
- W2889639332 cites W2043157312 @default.
- W2889639332 cites W2046710779 @default.
- W2889639332 cites W2050177842 @default.
- W2889639332 cites W2051920190 @default.
- W2889639332 cites W2055424631 @default.
- W2889639332 cites W2055584102 @default.
- W2889639332 cites W2057088909 @default.
- W2889639332 cites W2059848983 @default.
- W2889639332 cites W2060876152 @default.
- W2889639332 cites W2061261019 @default.
- W2889639332 cites W2065831401 @default.
- W2889639332 cites W2066278148 @default.
- W2889639332 cites W2066845344 @default.
- W2889639332 cites W2074549189 @default.
- W2889639332 cites W2075860675 @default.
- W2889639332 cites W2076176321 @default.
- W2889639332 cites W2082825961 @default.
- W2889639332 cites W2086525397 @default.
- W2889639332 cites W2089453524 @default.
- W2889639332 cites W2093030407 @default.
- W2889639332 cites W2095930129 @default.
- W2889639332 cites W2096388504 @default.
- W2889639332 cites W2100467261 @default.
- W2889639332 cites W2102560431 @default.
- W2889639332 cites W2102736236 @default.
- W2889639332 cites W2108725095 @default.
- W2889639332 cites W2108888253 @default.
- W2889639332 cites W2110870493 @default.
- W2889639332 cites W2111306860 @default.
- W2889639332 cites W2111602420 @default.
- W2889639332 cites W2112781395 @default.
- W2889639332 cites W2115284537 @default.
- W2889639332 cites W2115735198 @default.
- W2889639332 cites W2117840333 @default.
- W2889639332 cites W2119376007 @default.
- W2889639332 cites W2122648596 @default.
- W2889639332 cites W2123345024 @default.
- W2889639332 cites W2128818253 @default.
- W2889639332 cites W2130894316 @default.
- W2889639332 cites W2134414575 @default.
- W2889639332 cites W2139927177 @default.
- W2889639332 cites W2140674963 @default.
- W2889639332 cites W2140861987 @default.
- W2889639332 cites W2145684243 @default.
- W2889639332 cites W2147381804 @default.
- W2889639332 cites W2152546971 @default.