FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889650361> ?p ?o ?g. }

• W2889650361 abstract "Abstract Glucagon-mediated gene transcription in the liver is critical for maintaining glucose homeostasis. Promoting the induction of gluconeogenic genes and blocking that of insulin receptor substrate ( Irs )2 in hepatocytes contributes to the pathogenesis of type 2 diabetes. However, the molecular mechanism by which glucagon signalling regulates hepatocyte metabolism is not fully understood. We previously showed that a fasting-inducible signalling module consisting of general control non-repressed protein 5, co-regulator cAMP response element-binding protein binding protein/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2, and protein kinase A is required for glucagon-induced transcription of gluconeogenic genes. The present study aimed to identify the downstream effectors of this module in hepatocytes by examining glucagon-induced potential target genes. One of these genes was prolyl hydroxylase domain ( PHD )3, which suppressed stress signalling through inhibition of the IκB kinase–nuclear factor-κB pathway in a proline hydroxylase-independent manner to maintain insulin signalling. PHD3 was also required for peroxisome proliferator–activated receptor γ coactivator 1α-induced gluconeogenesis, which was dependent on proline hydroxylase activity, suggesting that PHD3 regulates metabolism in response to glucagon as well as insulin. These findings demonstrate that glucagon-inducible PHD3 regulates glucose metabolism by suppressing stress signalling and optimising gluconeogenesis and insulin signalling in hepatocytes." @default.
• W2889650361 created "2018-09-27" @default.
• W2889650361 creator A5002891606 @default.
• W2889650361 creator A5004508934 @default.
• W2889650361 creator A5006787725 @default.
• W2889650361 creator A5022683870 @default.
• W2889650361 creator A5029284832 @default.
• W2889650361 creator A5052984027 @default.
• W2889650361 creator A5054621091 @default.
• W2889650361 creator A5055640954 @default.
• W2889650361 creator A5057886306 @default.
• W2889650361 creator A5060761026 @default.
• W2889650361 creator A5067420768 @default.
• W2889650361 creator A5067902704 @default.
• W2889650361 creator A5076615057 @default.
• W2889650361 creator A5077633799 @default.
• W2889650361 creator A5081906664 @default.
• W2889650361 creator A5084777779 @default.
• W2889650361 date "2018-09-24" @default.
• W2889650361 modified "2023-10-16" @default.
• W2889650361 title "PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes" @default.
• W2889650361 cites W1523158326 @default.
• W2889650361 cites W1534360145 @default.
• W2889650361 cites W1537320491 @default.
• W2889650361 cites W1583767403 @default.
• W2889650361 cites W1656832639 @default.
• W2889650361 cites W1665938856 @default.
• W2889650361 cites W1944789111 @default.
• W2889650361 cites W1967364108 @default.
• W2889650361 cites W1969750989 @default.
• W2889650361 cites W1972688821 @default.
• W2889650361 cites W1988377666 @default.
• W2889650361 cites W1988760657 @default.
• W2889650361 cites W1991401793 @default.
• W2889650361 cites W1993987541 @default.
• W2889650361 cites W1998493448 @default.
• W2889650361 cites W2005195518 @default.
• W2889650361 cites W2005868568 @default.
• W2889650361 cites W2009010832 @default.
• W2889650361 cites W2013389269 @default.
• W2889650361 cites W2014887370 @default.
• W2889650361 cites W2019010829 @default.
• W2889650361 cites W2024324786 @default.
• W2889650361 cites W2024524127 @default.
• W2889650361 cites W2028035581 @default.
• W2889650361 cites W2028242823 @default.
• W2889650361 cites W2031637294 @default.
• W2889650361 cites W2038018821 @default.
• W2889650361 cites W2039765075 @default.
• W2889650361 cites W2040031153 @default.
• W2889650361 cites W2048456744 @default.
• W2889650361 cites W2049652810 @default.
• W2889650361 cites W2051636780 @default.
• W2889650361 cites W2066243203 @default.
• W2889650361 cites W2073656537 @default.
• W2889650361 cites W2075394689 @default.
• W2889650361 cites W2080863734 @default.
• W2889650361 cites W2080901528 @default.
• W2889650361 cites W2082064411 @default.
• W2889650361 cites W2094863064 @default.
• W2889650361 cites W2107401866 @default.
• W2889650361 cites W2107674876 @default.
• W2889650361 cites W2118483041 @default.
• W2889650361 cites W2124880593 @default.
• W2889650361 cites W2127684300 @default.
• W2889650361 cites W2131905943 @default.
• W2889650361 cites W2138266804 @default.
• W2889650361 cites W2142295769 @default.
• W2889650361 cites W2144625075 @default.
• W2889650361 cites W2146642780 @default.
• W2889650361 cites W2147950253 @default.
• W2889650361 cites W2148119611 @default.
• W2889650361 cites W2149854843 @default.
• W2889650361 cites W2152101492 @default.
• W2889650361 cites W2156708688 @default.
• W2889650361 cites W2158465207 @default.
• W2889650361 cites W2159664830 @default.
• W2889650361 cites W2168854431 @default.
• W2889650361 cites W2312282875 @default.
• W2889650361 cites W2509220708 @default.
• W2889650361 cites W2551054295 @default.
• W2889650361 cites W2587680743 @default.
• W2889650361 cites W2593244426 @default.
• W2889650361 cites W2626395293 @default.
• W2889650361 cites W4232166193 @default.
• W2889650361 cites W4239759145 @default.
• W2889650361 cites W1964184380 @default.
• W2889650361 cites W2038890616 @default.
• W2889650361 doi "https://doi.org/10.1038/s41598-018-32575-z" @default.
• W2889650361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155226" @default.
• W2889650361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250231" @default.
• W2889650361 hasPublicationYear "2018" @default.
• W2889650361 type Work @default.
• W2889650361 sameAs 2889650361 @default.
• W2889650361 citedByCount "13" @default.
• W2889650361 countsByYear W28896503612020 @default.
• W2889650361 countsByYear W28896503612021 @default.
• W2889650361 countsByYear W28896503612022 @default.
• W2889650361 countsByYear W28896503612023 @default.
• W2889650361 crossrefType "journal-article" @default.

• next